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Lo Vasco V.R.,University of Rome La Sapienza | Salmaso R.,Section of Anatomic Pathology | Zanardo V.,University of Padua | Businaro R.,Sapienza University Polo Pontino | And 3 more authors.
Journal of Reproductive Immunology

Several studies have reported that fetuses with intrauterine growth restriction (IUGR) and infants with low birth weight present increased intima/media thickness (aIMT) of the abdominal aorta wall compared with fetuses and infants appropriate for gestational age (AGA). Evidence suggested that aIMT might be related to inflammation, probably indicating a very early stage of future adulthood disease, such as atherosclerosis. We aimed to investigate histological findings in the abdominal aorta wall of one IUGR stillbirth in which ultrasound had detected aIMT. Microscopy observations of the abdominal aorta wall confirmed the intima thickening and detected condensation of the elastic fibers forming an evident internal elastic membrane and presence of inflammatory elements, such as macrophages, activated endothelial cells, and fibroblastoid cells. The present study highlights that IUGR associated with aIMT is related to inflammation, which might represent a very early sign of future adult lesions. © 2011 Elsevier Ireland Ltd. Source

Lo Vasco V.R.,University of Rome La Sapienza | Cosmi E.,University of Padua | Visentin S.,University of Padua | Di Raimo T.,University of Rome La Sapienza | And 4 more authors.
Journal of Reproductive Immunology

Intrauterine growth restriction (IUGR) and/or neonatal low birth weight are often associated with increased intima/media thickness of the abdominal aortic wall (aIMT). Several studies in children suggested that aIMT might be related to inflammation, probably indicating an early stage of adulthood diseases, such as atherosclerosis. Our previous study performed on the abdominal aortic wall of a stillbirth presenting with IUGR and aIMT suggested an association among IUGR, aIMT, and inflammation, also highlighting the presence of fibroblastoid cells, which are thought to represent peculiar elements of the pre-atherosclerotic lesions. These observations led us to analyze two cytokines involved in the inflammation cascade, IL-1β and IL-23, in amniotic fluid samples of IUGR fetuses and small-for-gestational-age newborns presenting with aIMT and in normal controls. Our results indicate that IL-23, but not IL-1β, concentrations differed in the groups analyzed. Therefore, IL-23, a regulatory element that bridges the innate and adaptive arms of the immune system, might be involved in the inflammatory process observed in fetal aIMT. © 2011 Elsevier Ireland Ltd. Source

Lo Vasco V.R.,University of Rome La Sapienza | Leopizzi M.,Sapienza University Polo Pontino | Chiappetta C.,Sapienza University Polo Pontino | Businaro R.,Sapienza University Polo Pontino | And 3 more authors.
Fertility and Sterility

Objective: To delineate the panel of expression of phosphoinositide- specific phospholipase C (PI-PLC) signaling enzymes in normal endometrium and in endometriosis. Design: Clinical/experimental study. Setting: University. Patient(s): Healthy donor woman and endometriosis-affected woman. Intervention(s): Normal endometrium and endometriosis surgical biopsies were analyzed using gene expression analyses methodology (reverse transcriptase-polymerase chain reaction [PCR], bioanalyses). Main Outcome Measure(s): Gene expression (messenger RNA concentration) measures of 12 PI-PLC enzymes: PI-PLC β1, PI-PLC β2, PI-PLC β3, PI-PLC β4, PI-PLC γ1, PI-PLC γ2, PI-PLC δ1, PI-PLC δ3, PI-PLC δ4, PI-PLC ε, PI-PLC η1, and PI-PLC η2. Result(s): PI-PLC β1, PI-PLC β3, PI-PLC δ1, and PI-PLC δ3 enzymes were detected, although differently expressed in normal and endometriosis tissues. Conclusion(s): The involvement of PI-PLC enzymes in inflammation and the consistency of susceptible endometriosis loci with PI-PLC genes mapping corroborate the hypothesis that PI signaling might be involved in the pathogenesis of endometriosis. Copyright © 2012 American Society for Reproductive Medicine, Published by Elsevier Inc. Source

Del Borgo C.,Sapienza University Polo Pontino | Gianfreda R.,Sapienza University Polo Pontino | Belvisi V.,Sapienza University Polo Pontino | Citton R.,Sapienza University Polo Pontino | And 4 more authors.
Infezioni in Medicina

A case of an immunocompetent man with acute CMV infection associated with a pulmonary embolism is described. Acute CMV infection could be a risk factor for developing thromboembolism. Pulmonary embolism should be included in differential diagnosis in patients with acute CMV infections and pulmonary opacities. Source

Ribuffo D.,University of Rome La Sapienza | Guerra M.,Unit of Plastic and Reconstructive Surgery | Di Benedetto G.M.,Marche Polytechnic University | Grassetti L.,Marche Polytechnic University | And 3 more authors.
European Review for Medical and Pharmacological Sciences

OBJECTIVE: Post-mastectomy radiotherapy (PMRT) is well known in the plastic surgery community for having a negative impact on expander-implant based immediate breast reconstruction (IBBR), although recently some technical improvements allow better results. Very recent papers would suggest that there is no difference in postoperative complications in patients receiving post-mastectomy radiotherapy using modern techniques. However, study results are often biased by small groups of patients and by heterogeneity of radiotherapy timing, different surgical techniques and measured outcomes. MATERIALS AND METHODS: We have conducted a MEDLINE search to summarize the latest data (2012-2014) on the topic. Search was conducted using the following parameters: breast reconstruction AND implant AND expander AND post-mastectomy radiotherapy. RESULTS: The MEDLINE search showed 53 reports, demonstrating a great interest on this topic; among these 37 dealed specifically with post-mastectomy radiotherapy after breast reconstruction. In particular, 15 were amenable to plastic surgeons, 6 to breast surgeons, 9 to radiotherapists and 7 to oncologists. Papers amenable to plastic surgeons highlighted the highest rate of undesired results, although with recent advances such as delayed-immediate reconstruction or protective lipofilling. CONCLUSIONS: PMRT remains an undesired event when pursuing an implant-based breast reconstruction, although it does not represent an absolute contraindication. The higher rate of complications reported by plastic surgeons and not by other specialists can be explained with the greater attention to aesthetic details, such as capsular contractures, that our community has. Technical strategies to prevent complications described in this community now allow better results, should be well known and improved if possible in the future. Source

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