Han Y.,Texas A&M University |
Glaser S.,Texas A&M University |
Glaser S.,Scott and White Digestive Disease Research Center |
Meng F.,Texas A&M University |
And 14 more authors.
Experimental Biology and Medicine | Year: 2013
This review focuses on the recent advances related to the heterogeneity of different-sized bile ducts with regard to the morphological and phenotypical characteristics, and the differential secretory, apoptotic and proliferative responses of small and large cholangiocytes to gastrointestinal hormones/peptides, neuropeptides and toxins. We describe several in vivo and in vitro models used for evaluating biliary heterogeneity. Subsequently, we discuss the heterogeneous proliferative and apoptotic responses of small and large cholangiocytes to liver injury and the mechanisms regulating the differentiation of small into large (more differentiated) cholangiocytes. Following a discussion on the heterogeneity of stem/progenitor cells in the biliary epithelium, we outline the heterogeneity of bile ducts in human cholangiopathies. After a summary section, we discuss the future perspectives that will further advance the field of the functional heterogeneity of the biliary epithelium. © 2013 by the Society for Experimental Biology and Medicine.
PubMed | University of Rome La Sapienza, Histological, Polo Pontino, Foro Italico University of Rome and Eleonora Lorillard Spencer Cenci Foundation
Type: Journal Article | Journal: Hepatobiliary surgery and nutrition | Year: 2014
Cholangiocarcinoma (CCA) is a very heterogeneous cancer from any point of view, including epidemiology, risk factors, morphology, pathology, molecular pathology, modalities of growth and clinical features. Given this heterogeneity, a uniform classification respecting the epidemiologic, pathologic and clinical needs is currently lacking. In this manuscript we discussed the different proposed classifications of CCA in relation with recent advances in pathophysiology and biology of this cancer.