Polo Pontino

Rome, Italy

Polo Pontino

Rome, Italy
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Semeraro R.,Polo Pontino | Semeraro R.,Eleonora Lorillard Spencer Cenci Foundation | Cardinale V.,Polo Pontino | Cardinale V.,Eleonora Lorillard Spencer Cenci Foundation | And 18 more authors.
Annals of Translational Medicine | Year: 2013

Patients affected by liver diseases and diabetes mellitus are in need for sources of new cells toenable a better transition into clinic programs of cell therapy and regenerative medicine. In this setting, fetalliver is becoming the most promising and available source of cells. Fetal liver displays unique characteristicsgiven the possibility to isolate cell populations with a wide spectrum of endodermal differentiation and, the co-existence of endodermal and mesenchymal-derived cells. Thus, the fetal liver is a unique and highlyavailable cell source contemporarily candidate for the regenerative medicine of both liver and pancreas. Thepurpose of this review is to revise the recent literature on the different stem cells populations isolable fromfetal liver and candidate to cell therapy of liver diseases and diabetes and to discuss advantages and limitationwith respect to other cell sources. © Annals of Translational Medicine.


Han Y.,Texas A&M University | Glaser S.,Texas A&M University | Glaser S.,Scott and White Digestive Disease Research Center | Meng F.,Texas A&M University | And 14 more authors.
Experimental Biology and Medicine | Year: 2013

This review focuses on the recent advances related to the heterogeneity of different-sized bile ducts with regard to the morphological and phenotypical characteristics, and the differential secretory, apoptotic and proliferative responses of small and large cholangiocytes to gastrointestinal hormones/peptides, neuropeptides and toxins. We describe several in vivo and in vitro models used for evaluating biliary heterogeneity. Subsequently, we discuss the heterogeneous proliferative and apoptotic responses of small and large cholangiocytes to liver injury and the mechanisms regulating the differentiation of small into large (more differentiated) cholangiocytes. Following a discussion on the heterogeneity of stem/progenitor cells in the biliary epithelium, we outline the heterogeneity of bile ducts in human cholangiopathies. After a summary section, we discuss the future perspectives that will further advance the field of the functional heterogeneity of the biliary epithelium. © 2013 by the Society for Experimental Biology and Medicine.


PubMed | University of Rome La Sapienza, Histological, Polo Pontino, Foro Italico University of Rome and Eleonora Lorillard Spencer Cenci Foundation
Type: Journal Article | Journal: Hepatobiliary surgery and nutrition | Year: 2014

Cholangiocarcinoma (CCA) is a very heterogeneous cancer from any point of view, including epidemiology, risk factors, morphology, pathology, molecular pathology, modalities of growth and clinical features. Given this heterogeneity, a uniform classification respecting the epidemiologic, pathologic and clinical needs is currently lacking. In this manuscript we discussed the different proposed classifications of CCA in relation with recent advances in pathophysiology and biology of this cancer.

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