Leitao A.,POLIS University |
Inverse Problems | Year: 2016
In this article we combine the projective Landweber method, recently proposed by the present authors, with Kaczmarz's method for solving systems of nonlinear ill-posed equations. The underlying assumption used in this work is the tangential cone condition. We show that the proposed iteration is a convergent regularization method. Numerical tests are presented for a nonlinear inverse problem related to the Dirichlet-to-Neumann map, indicating a superior performance of the proposed method when compared with other well established iterations. Our preliminary investigation indicates that the resulting iteration is a promising alternative for computing stable solutions of large scale systems of nonlinear ill-posed equations. © 2016 IOP Publishing Ltd.
Ippoliti R.,POLIS University
Value in Health | Year: 2013
Clinical research is a specific phase of pharmaceutical industry's production process in which companies test candidate drugs on patients to collect clinical evidence about safety and effectiveness. Information is essential to obtain manufacturing authorization from the national drug agency and, in this way, make profits on the market. Considering this activity, however, the public stakeholder has to face a conflict of interests. On the one side, there is society's necessity to make advances in medicine and, of course, to promote pharmaceutical companies' investments in this specific phase (new generation). On the other side, there is the duty to protect patients involved in these experimental treatments (old generation). To abide by this moral duty, a protection system was developed through the years, based on two legal institutions: informed consent and institutional review board. How should an efficient protection system that would take human experimentation into account be shaped? Would it be possible for the national protection system of patients' rights to affect the choice of whether to develop a clinical trial in a given country or not? Looking at Europe and considering a protection system that is shaped around institutional review boards, this article is an empirical work that tries to give answers to these open questions. It shows how a protection system that can minimize the time necessary to start a trial can positively affect pharmaceutical clinical research, that is, the choice of pharmaceutical companies to start innovative medical treatments in a given country. © 2013 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Publishedby Elsevier Inc.
Bozo L.,POLIS University |
Allkja S.,A.L.T.E.A and Geostudio 2000 company
Geotechnical Engineering for Infrastructure and Development - Proceedings of the XVI European Conference on Soil Mechanics and Geotechnical Engineering, ECSMGE 2015 | Year: 2015
Albania is a small country (28000km2) and with 3,5million habitants. Before 1990 in Albania was very developed some economical branches as in energy, in mines, métallurgic, mechanical, chemical, textile, nutritive industries. Also we had not much developed infrastructure of roads bur very well irrigation system with about 600 water reserved. After 1990 the great part of these activities was destroied, or abandoned to create zones with enormous pollution. In other part the big emigration and "free" movement of the population was created a chaos (confusion) on the environment's management. So today, in Albania, we have more and serious problems in the environment field. In this paper we would like to evidence some of these problems, what politics must take for their solution, how is tied geotechnics and geo-environment with these politics oriented not only to bring in normality the environment, but to sure a stable development of the country. Also we wont to present the experience of the Polis University which in the didactic, research and scientific planes can resolved these problems. © The authors and ICE Publishing: All rights reserved, 2015.
Falavigna G.,CNR Institute for Economic Research on Firms and Growth |
Ippoliti R.,Hospital SS. Antonio e Biagio e Cesare Arrigo Structure of Scientific Promotion |
Ippoliti R.,POLIS University |
Manello A.,CNR Institute for Economic Research on Firms and Growth
Health Care Management Science | Year: 2013
The present study considers the Italian healthcare system, investigating the aspects that might affect the efficiency of Italian hospitals. The authors analyze what influences a specific definition of efficiency, which is calculated maximizing healthcare production but minimizing potential financial losses. In other words, this work considers efficient each hospital which is able to maximize the production of medical treatments while complying, at the same time, with budget constraints. Hence, the results of this paper are twofold: from the organizational point of view, they underline the need for rebalancing the various administrative levels of hospitals; from the technical point of view, a more coherent model is proposed in order to account for all the aspects of the healthcare industry. © 2012 Springer Science+Business Media New York.
Di Novi C.,POLIS University
Health economics | Year: 2010
This paper employs the Behavioral Risk Factor Surveillance System (2001) data in conjunction with the Environmental Protection Agency's Air Quality System data to investigate how air pollution caused by motor vehicle emissions affects the likelihood of good health and the amount of health investments. Models are estimated using three different measures of overall health: a measure of self-assessed health and two health outcome indicators (asthma and blood pressure). A multivariate probit approach is used to estimate recursive systems of equations for self-assessed health, health outcomes and life-styles. The most interesting result concerns the influence of pollution on health-improving life-style choices: only if traffic pollution is in the 'satisfactory range' (AQI level at or below 100), individuals will have incentive to invest in health. Copyright © 2009 John Wiley & Sons, Ltd.