Time filter

Source Type

Legnani C.,Minimally Invasive Articular Surgery Unit | Zini S.,Policlinico Universitario accone | Borgo E.,Minimally Invasive Articular Surgery Unit | Ventura A.,Minimally Invasive Articular Surgery Unit
Archives of Orthopaedic and Trauma Surgery | Year: 2016

Introduction: With the increasing number of primary anterior cruciate ligament (ACL) reconstructions, revision surgery has become more frequent. The purpose of the present study is to retrospectively compare the clinical outcome of contralateral hamstring tendon autografts vs. allografts for ACL revision surgery, specifically with regard to patient satisfaction, return to preinjury activity level, and postoperative functional outcomes. Materials and methods: Between 2004 and 2011, 59 patients underwent ACL revision surgery. 44 were successfully recontacted and retrospectively reviewed at an average follow-up of 5.2 years. 23 subjects underwent revision ACL reconstruction with contralateral autogenous hamstring tendon grafts; 21 underwent allograft revision ACL surgery. Clinical, arthrometric, and functional evaluations were performed. The Tegner, Knee Injury and Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee (IKDC) Subjective Knee Form were used. Objective evaluation included range of motion, Lachman test, pivot-shift test and KT-1000 instrumented laxity testing. Results: No major complications were reported. Follow-up examination showed that there were no significant differences IKDC and KOOS scores between the groups. The percentage of patients returning to pre-injury level was high in both groups. Anterior tibial translation according to manual laxity testing and as measured with KT-1000 arthrometer was not statistically different in the two groups. With regard to return to sports, patients undergoing revision surgery with autografts experienced a quicker return to sports compared to patients who underwent allograft revision surgery. Conclusions: The use of contralateral hamstring tendon autografts for ACL revision surgery produced similar subjective and objective outcomes at 5.2 years follow-up compared to revision with allograft patellar or Achilles tendon. Patients undergoing revision surgery with autografts experienced a quicker return to sports compared to patients who underwent allograft revision surgery. © 2016, Springer-Verlag Berlin Heidelberg. Source

Santini D.,Biomedical University of Rome | Tampellini M.,University of Turin | Vincenzi B.,Biomedical University of Rome | Ibrahim T.,Osteo oncology Center | And 29 more authors.
Annals of Oncology | Year: 2012

Background: Data are limited regarding bone metastases from colorectal cancer (CRC). The objective of this study was to survey the natural history of bone metastasis in CRC. Patients and methods: This retrospective, multicenter, observational study of 264 patients with CRC involving bone examined cancer treatments, bone metastases characteristics, skeletal-related event (SRE) type and frequency, zoledronic acid therapy, and disease outcomes. Results: Most patients with bone metastases had pathologic T3/4 disease at CRC diagnosis. The spine was the most common site involved (65%), followed by hip/pelvis (34%), long bones (26%), and other sites (17%). Median time from CRC diagnosis to bone metastases was 11.00 months; median time to first SRE thereafter was 2.00 months. Radiation and pathologic fractures affected 45% and 10% of patients, respectively; 32% of patients had no reported SREs. Patients survived for a median of 7.00 months after bone metastases diagnosis; SREs did not significantly affect survival. Subgroup analyses revealed that zoledronic acid significantly prolonged median time to first SRE (2.00 months versus 1.00 month, respectively, P = 0.009) and produced a trend toward improved overall survival versus no zoledronic acid. Conclusion: This study illustrates the burden of bone metastases from CRC and supports the use of zoledronic acid in this setting. © The Author 2012. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. Source

Vernuccio F.,Sezione di Science Radiologiche | Grutta G.,Policlinico Universitario accone | Fazio G.,Poliambulatorio medico Riabiliter SNC
Recenti Progressi in Medicina | Year: 2014

Sudden cardiac death (SCD) in athletes is a rare but tragic event particularly considering that in some cases it is preventable. In young athletes with cardiovascular disease the risk of SCD is 2,5 times higher than in non-athletes. In young athletes (<35 years old), the most common causes of SCD are related to pre-existing cardiovascular disorders including hypertrophic cardiomyopathy, congenital coronary anomalies, arrhythmogenic right ventricular dysplasia, commotio cordis, some channelopathies and cardiac sarcoidosis. Actually there are two approches to pre-participation athletic screening: the American one based on anamnesis and physical examination and the European one based on anamnesis, physical examination and ECG at rest. However, some disorders responsible for SCD can't be suspected through these exams and it could be useful to implement preparticipation athletic screening. © 2014 II Pensiero Scientifico Editore. Source

Paparo F.,E.O. Ospedali Galliera | Cenderello G.,Unit of Infectious Diseases | Revelli M.,University of Genoa | Bacigalupo L.,E.O. Ospedali Galliera | And 8 more authors.
BioMed Research International | Year: 2015

Objective. To assess the diagnostic performance of a T1-independent, T2-corrected multiecho magnetic resonance imaging (MRI) technique for the quantification of hepatic steatosis in a cohort of patients affected by chronic viral C hepatitis, using liver biopsy as gold standard. Methods. Eighty-one untreated patients with chronic viral C hepatitis were prospectively enrolled. All included patients underwent MRI, transient elastography, and liver biopsy within a time interval <10 days. Results. Our cohort of 77 patients included 43/77 (55.8%) males and 34/77 (44.2%) females with a mean age of 51.31 ± 11.27 (18-81) years. The median MRI PDFF showed a strong correlation with the histological fat fraction (FF) (r=0.754, 95% CI 0.637 to 0.836, P<0.0001), and the correlation was influenced by neither the liver stiffness nor the T2 decay. The median MRI PDFF result was significantly lower in the F4 subgroup (P<0.05). The diagnostic accuracy of MRI PDFF evaluated by AUC-ROC analysis was 0.926 (95% CI 0.843 to 0.973) for S≥1 and 0.929 (95% CI 0.847 to 0.975) for S=2. Conclusions. Our MRI technique of PDFF estimation allowed discriminating with a good diagnostic accuracy between different grades of hepatic steatosis. © 2015 Francesco Paparo et al. Source

Terenziani M.,Fondazione Istituto Nazionale Dei Tumori | D'Angelo P.,ARNAS Civico | Inserra A.,Ospedale Pediatrico IRCCS Bambino Gesu | Boldrini R.,Ospedale Pediatrico IRCCS Bambino Gesu | And 12 more authors.
Pediatric Blood and Cancer | Year: 2015

Background: Teratomas demonstrate a benign clinical behavior, however they may recur with malignant components or as teratoma, and in a small group of patients prognosis could be fatal. After the first Italian study, we collected cases of teratoma, alongside the protocol for malignant germ cell tumors. Procedure: Patients with teratoma were collected from 2004 to 2014. Teratomas were classified according to the WHO classifications, as mature and immature. Patients with pathological aFP and/or bHCG, and those with a malignant germ cell component were not included. Results: The study enrolled 219 patients (150 mature, 69 immature teratomas) with a median age at diagnosis of 42 months. The primary sites involved were: 118 gonadal and 101 extragonadal teratomas. Two females with ovarian teratoma had a positive family history. Complete and incomplete surgeries were performed in 85% and 9% of cases. Seventeen events occurred: six females had a second metachronous tumor (5 contralateral ovarian teratoma, 1 adrenal neuroblastoma) and 11 teratomas relapsed/progressed (3 mature, 8 immature teratomas). Two patients died, one of progressive immature teratoma and one of surgical complications. At a median follow up of 68 months, the event-free, relapse-free, and overall survival rates were 90.6%, 94.3%, 98.6%, respectively. Conclusions: Teratomas show a good prognosis, especially the mature ones: surgery and follow-up remain the standard approach. Incomplete surgery in immature teratoma is the group at greatest risk of relapse. Bilateral ovarian tumors are a possibility, and the rare family predisposition to ovarian mature teratoma warrants further analyses. Pediatr Blood Cancer 2015;62:1202-1208. © 2015 Wiley Periodicals, Inc. Source

Discover hidden collaborations