Water exposure to bisphenol A and its chlorinated derivatives and links with breast cancer: Feasibility study BREDI I (Breast and Endocrine disrupter investigation Part 1) [Exposition hydrique au bisphénol a et à ses dérivés chlorés et liens avec le cancer du sein : Étude de faisabilité bredi I (breast and endocrine disrupter investigation part 1)]
Rouillon S.,CNRS Poitiers Institute of Chemistry: Materials and Natural Resources |
Grignon C.,CNRS Poitiers Institute of Chemistry: Materials and Natural Resources |
Venisse N.,Pole BioSPharm |
Nadeau C.,POle Femme Mere Enfant |
And 4 more authors.
Revue des Sciences de l'Eau
There is a relationship between exposure to endocrine disrupting chemicals (EDCs) and animal carcinogenesis. However, epidemiological data are insufficient. Bisphenol A (BPA) is a ubiquitous EDC present in drinking water. Its chlorinated derivatives (Clx-BPA) are suspected to have an ED action 100 times stronger than BPA itself. The aim of this study was to assess the feasibility of a trial about water exposure to BPA and Clx-BPA in a population of patients having breast surgery. The study was conducted at the University Hospital of Poitiers in three populations of women having breast surgery and classified according to the severity of their injury. Three methods to assess water exposure were explored: determination in biological matrices, in tap water and administration of a validated socio-demographic questionnaire for water exposure. The primary endpoint was the concentration of compounds in water or biological matrices and the amount of water provided by oral and dermal routes according to the questionnaire. In drinking water samples, BPA was quantified for every patient (116 ± 162 ng∙L-1). Clx-BPA concentrations were 1.85 ± 0.70 g∙L-1. Urinary BPA concentrations were 2.6 ng∙mL-1 preoperatively and 3.8 ± 5.5 ng∙mL-1 postoperatively; CLx-BPA have not been quantified. In breast adipose tissue, BPA was found at 1.265 ± 0.058 ng∙g-1, whereas BPA and BPA-Clx were only found two times. This study demonstrated the feasibility of BPA and Clx-BPA determinations in biological matrices and tap water. Performing a multicenter cohort study would allow an investigation of the relationship between exposure to EDCs and breast cancer. © 2015, Institut National de la Research Scientifique. All rights reserved. Source
Loock M.T.,Pole dImagerie |
Fornes P.,Service danatomopathologie |
Soyer P.,Paris West University Nanterre La Defense |
Graesslin O.,POle Femme Mere Enfant |
And 2 more authors.
Objective: The purpose of our article was to review the magnetic resonance imaging (MRI) features of pelvic abscesses. Pelvic abscesses account for a wide range of abnormalities from various etiologies. Conclusion: MRI is being increasingly used for pelvic exploration. Radiologists must thus be aware of their features and characteristics. © 2012 Elsevier Inc. Source
Coppola C.,POle Femme Mere Enfant |
Mottet N.,POle Femme Mere Enfant |
Mariet A.S.,Reseau daide methodologique ResAM |
Baeza C.,POle Femme Mere Enfant |
And 4 more authors.
Journal de Gynecologie Obstetrique et Biologie de la Reproduction
Objectives: To analyse the impact of external cephalic version (ECV) on caesarean section rate in a team with a high success rate of vaginal delivery in breech presentation. Materials and methods: Retrospective monocentric study including 298 patients with a breech presentations between 33 and 35. weeks of amenorrhea followed at our university hospital and delivered after 35. weeks, between 1st January 2011 and 31st December 2013. Patients were divided into 2 groups: planned ECV (n = 216 patients) versus no planned ECV (n = 57 patients). Results: Our rate of successful vaginal breech delivery over the period of the study was 61.1%. We performed 165 ECV, with a 21.8% success rate. The average term of the attempt of ECV was 36.7. weeks of amenorrhea. The caesarean section rate was not significantly different in the planned ECV group, even after adjustment on age, parity and previous caesarean delivery (adjusted OR = 1.67 [0.77-3.61]). Attempt of ECV did not reduce the number of breech presentation at delivery (61.1% versus 61.4% [. P = 0.55]). Conclusion: Planned ECV in our center with a high level of breech vaginal delivery did not significantly impact our cesarean section rate. © 2016 Elsevier Masson SAS. Source