Besançon, France
Besançon, France

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Parent G.,Pole pharmaceutique | Mottet N.,Pole Mere Enfant | Mairot P.,Pole pharmaceutique | Baudier F.,Observatoire du medicament et des innovations therapeutiques OMEDIT de Franche Comte | And 4 more authors.
Journal de Gynecologie Obstetrique et Biologie de la Reproduction | Year: 2016

Objective The aim of the study was to describe the prescribing of drugs to pregnant women during the third trimester of pregnancy. Patients and methods The retrospective analysis is interested by pregnant women from August 2009 to April 2011, living in Franche-Comté. The used data are recorded in the database of the French Health Insurance Service. Drugs prescribing were analyzed and classified according to three categories: drugs that are contraindicated, not recommended drugs and drugs that are used. This classification is based on two databases: the Summaries of Product Characteristics of Vidal 2010 and data from the National Security Agency of Medicines. The potential exposure of patients was pointed out. Results On 15,027 patients, 80% had a prescription. Six percent of prescriptions containing drugs not recommended and 1% drugs that contraindicated. Therapeutic classes identified are analgesics, anti-infective drugs and medicines supplementing with vitamins and minerals. Contraindicated drugs (10%) are NSAIDs, rubella vaccine, cyclins and ACE inhibitors and ARBs. Approximately 2.7% of women were potentially exposed to these drugs. Discussion and conclusion Despite the recommendations of the ANSM, some drugs that are contraindicated are prescribed for pregnant women in their third trimester of pregnancy. In the absence of studies, the decision must be made on a case by case basis by assessing the risk–benefit ratio. Particular care is to bring about the drugs taken in self-medication. Information and advice are key steps to avoid incidents. © 2015 Elsevier Masson SAS


Sabouraud-Leclerc D.,Reims University Hospital Center | Frere S.,Reims University Hospital Center | Anton M.,Nantes University Hospital Center | Bocquel N.,Pole mere enfant | And 8 more authors.
Revue Francaise d'Allergologie | Year: 2013

Therapeutic education of children (and their parents) with asthma and/or food allergy is aimed at attaining and/or maintaining the capacities which they need to better manage their life with these chronic illnesses. It can be done in individualized and/or in group educative consultations. We begin with our experience with individualized educative consultations at the Reims CHU and show the complimentary aspects of two methods, together with medical management. © 2013 Elsevier Masson SAS.


PubMed | Pole Mere Enfant, Observatoire du medicament et des innovations therapeutiques OMEDIT de Franche Comte and Pole pharmaceutique
Type: Journal Article | Journal: Journal de gynecologie, obstetrique et biologie de la reproduction | Year: 2016

The aim of the study was to describe the prescribing of drugs to pregnant women during the third trimester of pregnancy.The retrospective analysis is interested by pregnant women from August2009 to April2011, living in Franche-Comt. The used data are recorded in the database of the French Health Insurance Service. Drugs prescribing were analyzed and classified according to three categories: drugs that are contraindicated, not recommended drugs and drugs that are used. This classification is based on two databases: the Summaries of Product Characteristics of Vidal 2010 and data from the National Security Agency of Medicines. The potential exposure of patients was pointed out.On 15,027patients, 80% had a prescription. Six percent of prescriptions containing drugs not recommended and 1% drugs that contraindicated. Therapeutic classes identified are analgesics, anti-infective drugs and medicines supplementing with vitamins and minerals. Contraindicated drugs (10%) are NSAIDs, rubella vaccine, cyclins and ACE inhibitors and ARBs. Approximately 2.7% of women were potentially exposed to these drugs.Despite the recommendations of the ANSM, some drugs that are contraindicated are prescribed for pregnant women in their third trimester of pregnancy. In the absence of studies, the decision must be made on a case by case basis by assessing the risk-benefit ratio. Particular care is to bring about the drugs taken in self-medication. Information and advice are key steps to avoid incidents.


Castelain-Hacquet C.,Service dallergologie | Anton M.,Nantes University Hospital Center | Bocquel N.,Pole mere enfant | Cordebar V.,Nancy University Hospital Center | And 8 more authors.
Revue Francaise d'Allergologie | Year: 2011

Severe food allergies, sometimes involving the vital forecast of the patients, are frequent and often carry away consultations and hospitalizations. Treatments according to the indications are still often the allergen eviction to avoid the accidents or the administration of the oral tolerance protocols, which require information and skill on behalf of the patients and of their family. The Research group in therapeutically education in food allergy (Groupe de recherche en éducation thérapeutique dans l'allergie alimentaire), in the light of the recommendations of the French Health Authorities (HAS) in patients therapeutically education, has written the reference table of skills to be acquired by the patients to train in the educational tools. It would specify the way of creating and using them, in connection with the objectives of the reference table of skills. They were estimated and validated, with the aim of harmonizing the practices in this domain; these tools should arise to the largest number of teams interested in the therapeutic education in food allergy. © 2011.


Storme L.,Lille 2 University of Health and Law | Aubry E.,Lille 2 University of Health and Law | Rakza T.,Lille 2 University of Health and Law | Houeijeh A.,Pole Femme Mere Nouveau ne | And 4 more authors.
Archives of Cardiovascular Diseases | Year: 2013

The main cause of pulmonary hypertension in newborn babies results from the failure of the pulmonary circulation to dilate at birth, termed 'persistent pulmonary hypertension of the newborn' (PPHN). This syndrome is characterized by sustained elevation of pulmonary vascular resistance, causing extrapulmonary right-to-left shunting of blood across the ductus arteriosus and foramen ovale and severe hypoxaemia. It can also lead to life-threatening circulatory failure. There are many controversial and unresolved issues regarding the pathophysiology of PPHN, and these are discussed. PPHN is generally associated with factors such as congenital diaphragmatic hernia, birth asphyxia, sepsis, meconium aspiration and respiratory distress syndrome. However, the perinatal environment-exposure to nicotine and certain medications, maternal obesity and diabetes, epigenetics, painful stimuli and birth by Caesarean section-may also affect the maladaptation of the lung circulation at birth. In infants with PPHN, it is important to optimize circulatory function. Suggested management strategies for PPHN include: avoidance of environmental factors that worsen PPHN (e.g. noxious stimuli, lung overdistension); adequate lung recruitment and alveolar ventilation; inhaled nitric oxide (or sildenafil, if inhaled nitric oxide is not available); haemodynamic assessment; appropriate fluid and cardiovascular resuscitation and inotropic and vasoactive agents. © 2013 Elsevier Masson SAS.


PubMed | Pole mere enfant
Type: Journal Article | Journal: Journal de gynecologie, obstetrique et biologie de la reproduction | Year: 2016

To propose a protocol for induction of labor to terminate pregnancy after 22weeks of amenorrhea allowing to decrease the duration of labor and of hospitalization but also, allowing to reduce the number of emergency pretreatment-induced fetal death, to improve the experience of the patients and to limit the cost.We realized a retrospective single-center study including 269patients and comparing three protocols, with and without laminaria and with various intervals mifepristone-misoprostol (14and 38hours). The outcome measures were the misoprostol-delivery interval, the delivery time and the number of emergency pretreatment-induced fetal death.We showed that the misoprostol-delivery interval and the delivery time were comparable for the three periods of our study, even after decrease of 24hours of the mifepristone-misoprostol interval and in the absence of laminaria. The misoprostol-delivery interval was between 7h30and 8h35between protocols (P=0.055). The delivery time was between 5:18pm and 6:48pm between protocols (P=0.252). The early administration of misoprostol allowed the patients to give birth earlier (P=0.001). Finally, we showed that the increase of the size and the number of laminarias were risk factors of emergency pretreatment-induced fetal death (respectively P=0.013and P=0.002).The absence of laminaria and the reduction of the interval mifepristone-misoprostol of 24hours do not change the time to delivery and allow to reduce the duration of hospitalization, the number of emergency pretreatment-induced fetal death and the cost of the TOP.


Couteau C.,Pole Mere enfant | D'Ercole C.,Pole Mere enfant | Bretelle F.,Pole Mere enfant | Boubli L.,Pole Mere enfant | And 2 more authors.
Journal de Gynecologie Obstetrique et Biologie de la Reproduction | Year: 2016

Objectives. - To propose a protocol for induction of labor to terminate pregnancy after 22 weeks of amenorrhea allowing to decrease the duration of labor and of hospitalization but also, allowing to reduce the number of emergency pretreatment-induced fetal death, to improve theexperience of the patients and to limit the cost. Methods. - We realized a retrospective single-center study including 269 patients and comparing three protocols, with and without laminaria and with various intervals mifepristone-misoprostol (14 and 38 hours). The outcome measures were the misoprostol-delivery interval, the delivery time and the number of emergency pretreatment-induced fetal death. Results. - We showed that the misoprostol-delivery interval and the delivery time were comparable for the three periods of our study, even after decrease of 24 hours of the mifepristone-misoprostol interval and in the absence of laminaria. The misoprostol-delivery interval was between 7 h 30 and 8 h 35 between protocols (P = 0.055). The delivery time was between 5:18 pm and 6:48 pm between protocols (P = 0.252). The early administration of miso-prostol allowed the patients to give birth earlier (P = 0.001). Finally, we showed that the increase of the size and the number of laminarias were risk factors of emergency pretreatment-induced fetal death (respectively P = 0.013 and P = 0.002). Conclusion. -The absence of laminaria and the reduction of the interval mifepristone-misoprostol of 24 hours do not change the time to delivery and allow to reduce the durationof hospitalization, the number of emergency pretreatment-induced fetal death and the cost of the TOP. © 2015 Elsevier Masson SAS.

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