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Nayak M.T.,Vyas Dental College and Hospital | Singh A.,Vyas Dental College and Hospital | Desai R.S.,Nair Hospital Dental College | Vanaki S.S.,PMNM Dental College and Hospital
Journal of Cancer Epidemiology | Year: 2013

Background. Oral submucous fibrosis (OSF), a precancerous condition, is characterized by abnormal accumulation of collagen fibers in oral submucosa. Vimentin is a Class 2 intermediate filament (IF) and primarily expressed in cells of mesenchymal origin. Vimentin is also found to be involved in cell growth, cell cycling, and tumour differentiation. Objective. The purpose of the study was to compare the expression of vimentin in various histological grades of OSF. Materials and Methods. To assess the immunohistochemical expression of vimentin in 20 mild cases of OSF, 20 severe cases of OSF, and ten cases of normal oral buccal mucosa. Results. The overall staining intensity of vimentin significantly increased statistically (P<0.01) in OSF cases over normal control. A significant increase in the staining intensity of vimentin was also noted in the fibroblasts of severe cases of OSF (P=0.03). Conclusion. Considering the marked vimentin expression in the present study, future studies should include cytoskeleton IF and other filaments in the fibroblasts of OSF. © 2013 Meghanand T. Nayak et al. Source

Kalburgi N.B.,PMNM Dental College and Hospital
Journal of oral science | Year: 2010

Recent studies have focused on genetic polymorphism of the interleukin-6 (IL-6) gene, which has led to a better understanding of the intricate interactions between host response, microorganisms, and genetics. Genotype prevalence appears to vary by the race and ethnicity of the population studied. We used a polymerase chain reaction technique to determine the prevalence of single nucleotide polymorphism in IL-6 at position -174 G>C in a population of 30 South Indians. Blood samples were collected from 15 chronic periodontitis patients and 15 healthy controls. The results showed that the G/G genotype was significantly more frequent in the chronic periodontitis group and that the C/C genotype was significantly more frequent in the control group (P = 0.0069 for both). The G allele was more frequent in chronic periodontitis patients (76.67%), whereas the C allele was more frequent in the control group (73.33%). Among chronic periodontitis patients, the odds ratio for having the G allele, as compared with the controls, was 9.04. In this population, the presence of the G/G genotype of IL-6 (-174) might increase susceptibility to chronic periodontitis, whereas the C/C genotype may have a protective effect. Source

Nimbalkar-Patil S.,University of Kuala Lumpur | Vaz A.,PMNM Dental College and Hospital | Patil P.G.,International Medical University
Journal of Clinical and Diagnostic Research | Year: 2014

Objective: To evaluate microleakage when two types of retainer wires were bonded with two light cured and a self cured lingual retainer composites.Materials and Methods: Total 120 freshly extracted human mandibular incisor teeth were collected and separated into six subgroups of 20 teeth each. Two different wires, a 0.036 inch hard round stainless steel (HRSS) wire sandblasted at the ends and 0.0175 inch multistranded wire bonded onto the lingual surfaces of the incisors with three different types of composite resins of 3M company; Concise Orthodontic (self-cure), Transbond XT (light-cure) and Transbond LR (light-cure). Specimens were further sealed with a nail varnish, stained with 0.5% basic fuchsine for 24 hours, sectioned and examined under a stereomicroscope, and scored for microleakage for the enamel-composite and wire-composite interfaces. Statistical analysis was performed by Kruskal-Wallis and Mann-Whitney U-tests.Results: For HRSS wire, at the enamel-composite interface, the microleakage was least with Transbond LR followed by Concise Orthodontic and greatest for Transbond XT (P<0.05). At the wire composite interface too, the microleakage was in order of Transbond LR Source

Vaz A.C.,PMNM Dental College and Hospital | Bai P.M.,HiTech Dental College and Hospital
Indian Journal of Dental Research | Year: 2015

Context: Tongue-tie (more formally known as ankyloglossia) is a congenital anomaly characterized by an abnormally short lingual frenulum, which may restrict mobility of the tongue tip impairing its ability to fulfill its functions. The clinical significance of ankyloglossia is varied; rarely symptomatic to a host of problems including infant feeding difficulties, speech disorders, malocclusions, and others. Aims: The need of this study was to evaluate the occurrence and severity of tongue-tie and its association with the type of malocclusions in two populations and also to correlate the various malocclusion traits with the grades of tongue-tie. Subjects and Methods: A total of 700 school children in the age group of 9-17 years were examined for the presence of tongue-tie, 350 from regular schools and 350 from special schools. The presence was evaluated, measured, and graded into Grades I-V according to Kotlow′s method. The malocclusion was assessed according to Angle′s classification. Severity of crowding was assessed by Little′s irregularity index in each case. Various other malocclusion traits were visually assessed, in relation to the positions of the teeth. Statistical Analysis Used: Spearman′s rank correlation method was used to test the relationship between type of malocclusions, grades of tongue-tie and severity of crowding. Significance was considered at the (P < 0.05) level. Results: Statistically significant differences were seen between grades of tongue-tie and Angle′s types of malocclusion and Spearman′s correlation between them showed negative correlation. The Spearman′s correlation showed a negative correlation between tongue-tie grades and severity of crowding. Conclusions: As the grade of tongue-tie increased, its association with Classes I and II malocclusion decreased. The lower grades of tongue-tie are associated with increased lower incisor crowding. Shorter, tight frenulums are more associated with maxillary constriction, anterior open bite, and spacing of the lower anteriors. © 2015 Indian Journal of Dental Research | Published by Wolters Kluwer - Medknow. Source

Kamat M.S.,Bharati Vidyapeeth Deemed University | Puranik R.S.,PMNM Dental College and Hospital | Hallur N.H.,Al Badar Dental College and Hospital | Kumar V.V.,Rajarajeshwari Dental College and Hospital | Kamat S.B.,Bharati Vidyapeeth Deemed University
Journal of Clinical and Diagnostic Research | Year: 2016

Oral Submucous Fibrosis (OSMF) is a chronic debilitating, potentially malignant disorder of the oral cavity. It is characterized by restricted mouth opening which results due to abnormal accumulation of collagen in the sub-epithelial layers leading to dense fibrous bands in the mouth. The pathogenesis of the disease is believed to be multifactorial. However, literature reports suggest a strong association of OSMF and arecanut chewing habit. The present paper presents a case of OSMF in a 12-year-old boy without arecanut chewing habit, but with a heavy practice of chewing tamarind seeds. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved. Source

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