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Sahoo R.,Nilai University College | Sahoo S.,Melaka Manipal Medical College | Sahoo S.,PLNayak Institute of Nanobiotechnology | Nayak P.L.,Plnayak Research Foundation
European Journal of Scientific Research | Year: 2011

In the present research program polycaprolactone was blended with gelatin at different proportions. This blend material was further blended with Cloisite 30 B to obtain the nanocomposites. The nanocomposites were blended with paclitaxel, an anti cancer drug, to study the in vitro drug delivery kinetics. The nanocomposites were characterized by using FTIR, SEM and XRD technique. The drug delivery kinetics was monitored at different pH medium and the kinetic parameters were evaluated. Based on the values of the kinetic parameters the mechanism of controlled drug delivery has been proposed. Source


Sahoo S.,Melaka Manipal Medical College | Sahoo R.,NUC | Nanda R.,Plnayak Research Foundation | Tripathy M.K.,UiTM | Nayak P.L.,Plnayak Research Foundation
European Journal of Scientific Research | Year: 2010

Quest is on for finding a novel drug delivery system that can overcome all the barriers the ocular tissues and to achieve a successful delivery of drug to the posterior structures of the human eye. We all know that majority of drug administration for any eye ailments are through topical solution or suspensions. Various viscous as well as synthetic polymers have been tried for quite some decade for having a good and sustained drug delivery to eye. Recent interests and technological innovations by using nanotechnology show promising revolutions in ocular drug delivery in days to come. Current research has been directed towards the use of naturally occurring polymers in a particular nanoparticulate system. Many studies have been conducted by using various naturally occurring mucoadhesive polymers. There are two broad classes of mucoadhesive polymers: hydrophilicpolymer and hydrogels. In the large classes of hydrophilic polymers those containing carboxylic group exhibit the best mucoadhesive properties, poly vinylpyrrolidone (PVP), Methyl cellulose (MC), Sodium carboxy methylcellulose (SCMC) Hydroxy propyl cellulose (HPC) and other cellulose derivative. Hyrogels are the class of polymeric biomaterial that exhibit the basic characteristics of an hydrogels to swell by absorbing water interacting by means of adhesion with the mucus that covers epithelia The naturally occurring polymers extracted from Tamarind seed are found to be more promising and many researchers are studying their uses in ocular drug delivery. Seeds of the tamarind tree (Tamarindus indica) contain a xyloglucan, which is a gel forming polysaccharide having mucoadhesive properties. Although tamarind xyloglucan itself does not form a gel, gel can be obtained under appropriate conditions, such as by adding some substances or removing substituent. © EuroJournals Publishing, Inc. 2010. Source


Sahoo D.,Plnayak Research Foundation | Nayak P.L.,Plnayak Research Foundation
Journal of Applied Polymer Science | Year: 2012

In this research program, chitosan film was prepared by blending chitosan with Cloisite 30 B at different concentrations 0 wt %, 1 wt %, and 2.5 wt %. The blends were characterized by Fourier transmission infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis. From the FTIR spectra the various groups present in chitosan/C 30 B blend were monitored. The homogeneity, morphology, and crystallinity of the blends were ascertained from SEM and XRD data, respectively. The most suitable form of blend was taken and used as a carrier for the controlled release of ofloxacin. The swelling studies have been carried out at different drug loading. Drug release kinetics was analyzed by plotting the cumulative release data versus time by fitting to an exponential equation which indicated the occurrence of non-Fickian type of kinetics. The drug release was investigated at different pH medium and it was found that the drug release depends upon the pH medium as well as the nature of matrix. © 2011 Wiley Periodicals, Inc. Source


Sahoo R.,Nilai University College | Sahoo S.,Plnayak Research Foundation | Nayak P.,P.A. College | Sahoo S.,Melaka Manipal Medical College | Nayak P.,Plnayak Research Foundation
European Journal of Scientific Research | Year: 2011

Two most important biodegradable polymers such as polycaprolactone and polylactic acid have been compounded in different proportions with organoclay MMT by melt blending.Organo clay MMT was added to enhance their compatibility and mechanical properties.The materials were characterized by using XRD, FTIR, thscanning electron microscopy, and thermogravimetric analysis.XRD results indicatedthat the materials formed intervcalated the nano composites.SEM morphology showed that the increasing content of MMT reduces the domain size of phase separated particles.The controlled drug delivery system has been studied using these bionanocomposites as the carrier. The kinetic parameters have been evaluated and the drug delivery mechanism has been suggested. © EuroJournals Publishing, Inc. 2011. Source


Sahoo S.,Plnayak Research Foundation | Sasmal A.,Plnayak Research Foundation | Nanda R.,Plnayak Research Foundation | Phani A.R.,Nano Research for Advanced Materials and Technologies | Nayak P.L.,Plnayak Research Foundation
Carbohydrate Polymers | Year: 2010

In the present research work chitosan has been blended with different amounts of polycaprolactone (PCL) (80:20, 75:25, 60:40 and 50:50) for using them for control delivery of ofloxacin. The blends were characterized by Fourier transmission infra red spectroscopy (FTIR), UV-visible spectroscopy (UV), scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis. From the FTIR spectra the various groups present in chitosan and PCL blend were monitored. The homogeneity, morphology and crystallinity of the blends were ascertained from SEM and XRD data, respectively. The swelling studies have been measured at different drug loading. The kinetics of the drug delivery system has been systematically studied. Drug release kinetics was analyzed by plotting the cumulative release data vs. time by fitting to an exponential equation which indicated the non-Fickian type of kinetics. The drug release was investigated at different pH medium and it was found that the drug release depends upon the pH medium as well as the nature of matrix. © 2009 Elsevier Ltd. Source

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