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Liu Y.,307 Hospital of PLA | Zhang Z.,PLA Institute of Orthopedics | Liu S.,307 Hospital of PLA | Su X.,307 Hospital of PLA | Zhou S.,Capital Medical University
International Journal of Clinical and Experimental Medicine | Year: 2015

Background: VEGF plays an important role in bone formation and repair. However, the effects of VEGF -634G/C polymorphisms on the pathogenesis of osteonecrosis of the femoral head (ONFH) were not conclusive. Our research was aimed to further analyze the association of VEGF -634G/C polymorphism with ONFH risk. Methods: The relevant articles were searched in PubMed, Elsevier, EMBASE, Web of Science and Chinese National Knowledge Infrastructure (CNKI) database. And a total of 692 cases and 875 controls were included. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the correlation of VEGF -634G/C polymorphism and ONFH susceptibility. Chi-square based Q-statistic test was used to evaluate heterogeneity among the studies. The random-effects model or fixed-effects model was used depending on heterogeneity. Results: The sensitivity analysis and publication bias test indicated that our results were stable and credible. And the results suggested that VEGF -634G/C polymorphism was significantly related with increased risk for ONFH in Asian population (CC versus GG: OR=1.34, 95% CI=1.02-1.76). Conclusion: The results indicated that VEGF -634G/C polymorphism might serve as genetic-susceptibility factor for ONFH. © 2015, E-Century Publishing Corporation. All rights reserved. Source


Li L.H.,PLA Institute of Orthopedics
Zhongguo gu shang = China journal of orthopaedics and traumatology | Year: 2013

To assess the early efficacy of metallic modular radial head prostheses in patients with Mason III and IV unreconstructable radial head fractures. The medical records of 16 patients (9 males, 7 females) with a mean age of 43 years old (31 to 57) with Mason III/IV unreconstructable radial head fractures requiring metallic modular radial head replacement between January 2009 and March 2012, were reviewed retrospectively. The functional results were assessed by range-of-movement, Mayo elbow performance score (MEPS). All patients underwent radiographic evaluation for radial head height and radiolucent lines. Fourteen patients were evaluated with follow-up for 12 to 33 months with an average of 23 months. Range of movement parameters was significantly lower in the affected elbow than in the unaffected side (P < 0.01). MEPS results were excellent in 9 cases, good in 2 cases, fair in 2 cases, and poor in 1 case. According to Grewal grading, there were 4 cases of periprosthetic lucencies of the radius and 1 case had significant clinical signs of loosening. Radial head replacement with the metallic modular prostheses yields satisfactory results regarding range of motion and function of the elbow joint in short term. The evolution of this prostheses needs to be evaluated with further studies to assess mid-term and long-term follow-up results. Source


Li L.,PLA Institute of Orthopedics | Ren J.,PLA Institute of Orthopedics | Liu J.,PLA Institute of Orthopedics | Wang H.,PLA Institute of Orthopedics | And 3 more authors.
PLoS ONE | Year: 2015

Background In 2009 two RCTs were publicated to question the efficacy of vertebroplasty comparing with sham treatment (ST) in the New England Journal of Medicine (NEJM), which provoked an academic debate on the efficacy of PVA. The purposes of our study were to compare clinical differences in pain relief, spinal functional outcomes, and overall quality of life between PVA and CT for painful osteoporotic VCFs. Methods We searched PubMed, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials and Web of Knowledge from January 1980 to June 2013 with Medical Subject Headings terms and keywords. Risk of bias in the included studies was assessed in accordance with the Cochrane risk of bias tool. In this Meta-analysis dichotomous and continuous variables were calculated using the risk ratio (RR) and standardized mean difference (SMD), respectively. Results Eight studies involving 987 patients met the criteria for inclusion. The VAS SMD was favoring the experimental group significantly (p < 0.001). Subgroup analysis suggested that the patients performed PVA with mean fracture age less than 3 months would got pain relief earlier and more durable than the control group (P <0.05). The SMD of spinal function assessed with RDQ and Oswestry LBP data was in favor of the experimental groups. QOL outcome improvement was demonstrated statistically significant at early, middle and lateterm follow-up for PVA than the control group (P <0.05). Conclusions In conclusion, this meta-analysis, which evaluated PVA for osteoporotic VCFs, demonstrated significant improvement regarding VAS, spinal function and QOL outcomes. The optimal fracture age was less than 12 weeks. © 2015 Li et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Source

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