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Vollmer S.A.,University of Bath | Feil E.J.,University of Bath | Chu C.-Y.,Beijing Institute of Microbiology and Epidemiology | Chu C.-Y.,PLA Institute of Disease Control and Prevention | And 4 more authors.
Infection, Genetics and Evolution | Year: 2013

The Lyme borreliosis (LB) group of spirochaetes currently comprises 18 named species that vary in their geographic distribution, host specificity and ability to cause disease in humans. In Europe three species are most abundant, Borrelia afzelii, Borrelia garinii and Borrelia valaisiana but only two of these (B. garinii and B. afzelii) are regularly found in Asia as well. A recently published study has shown that Borrelia species associated with birds, such as B. garinii, showed limited geographic structuring between European countries while, the rodent associated species, B. afzelii, showed extensive spatial structuring in Europe. Here, we use multilocus sequence analysis to show that when the wider, inter-continental, distribution is considered, there is evidence of spatial structuring even in the bird-associated species B. garinii. Furthermore, our investigations into historical LB populations provided evidence for range expansions of B. garinii and B. afzelii populations in Europe in the distant past. We propose that the expansion of B. afzelii in Europe may be linked to rodent population expansions after the last glacial maximum. © 2012 Elsevier B.V. Source


Wang J.,China University of Mining and Technology | Cao Z.,CAS Institute of Automation | Wang Q.,U.S. Center for Disease Control and Prevention | Wang X.,U.S. Center for Disease Control and Prevention | Song H.,PLA Institute of Disease Control and Prevention
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2011

Based on the spatial units of community, village and town in Beijing, the relationship betweent HFMD morbidity and the potential risk factors has been examined. According to the 6 selected risk factors (namely population density, disposable income of urban residents, the number of medical and health institutions, the number of hospital beds, average annual temperature and average annual relative humidity) significantly related to HFMD morbidity, the prediction performance of Classical Linear Regression Model(CLRM) and Spatial Lag Model(SLM) has been compared. The results showed that SLM achieved better effect and R square reached 0.82. It was showed that spatial effect played the crucial role in the HFMD morbidity prediction and its contribution attained 88%. However, CLRM showed low prediction accuracy and bias estimation. It was demonstrated that including spatial effect item into CLRM could greatly improve the performance of HFMD morbidity prediciton model. © 2011 Springer-Verlag. Source


Wang Y.,PLA Institute of Disease Control and Prevention | Zhang S.,Centers for Disease Control and Prevention | Yu J.,Chinese Institute of Basic Medical Sciences | Zhang H.,PLA Institute of Disease Control and Prevention | And 5 more authors.
Food Control | Year: 2010

We report an outbreak of food poisoning that occurred in August 2008 in a group of 13 persons who ate Stewed Pork Balls in Brown Sauce in Beijing. Epidemiology investigation and case-control analysis indicated that the Stewed Pork Balls in Brown Sauce was the source of food poisoning (OR 3.34, 95% CI 1.30-8.65). With the different measurements including API 20E and PCR, Dienes typing and PFGE, Proteus mirabilis was identified as a contributor to this matter, which evaluated by analyzing the collectives, which derived from contaminated food, patients, cook handlers and waiter. So this is the first report that P. mirabilis as a culprit resulted in food poisoning in Beijing. © 2009 Elsevier Ltd. Source


Chu C.-Y.,Beijing Institute of Microbiology and Epidemiology | Chu C.-Y.,PLA Institute of Disease Control and Prevention | Jiang B.-G.,Beijing Institute of Microbiology and Epidemiology | He J.,Beijing Institute of Microbiology and Epidemiology | And 10 more authors.
Vector-Borne and Zoonotic Diseases | Year: 2011

Thirty-two strains of Borrelia burgdorferi sensu lato were isolated from Ixodes persulcatus ticks collected from northeastern China from May to June in 2004 and 2005. Restriction fragment length polymorphism (RFLP) analysis and sequence analysis of 5S-23S rRNA intergenic spacer revealed that 29 (90.6%) belonged to Borrelia garinii, demonstrating B, C, and a unique pattern. The remaining three isolates (9.4%) were Borrelia afzelii with pattern D. The phylogenetic analysis based on 5S-23S rRNA intergenic spacer showed that B. garinii and B. afzelii genospecies clustered into two separate lineages. B. garinii strains were classified into three different branches: All the strains with RFLP pattern C were in the same branch, strain VH10 with a unique RFLP pattern clustered with strains VH9 and MDH2 with pattern B, and the rest of the strains with pattern B constitute another branch. These findings demonstrate the genetic diversity of B. burgdorferi sensu lato isolates from northeastern China. © 2011, Mary Ann Liebert, Inc. Source


Jiang T.-J.,302 Hospital | Zhang J.-Y.,Research Center for Biological Therapy | Li W.-G.,302 Hospital | Xie Y.-X.,302 Hospital | And 5 more authors.
Clinical Immunology | Year: 2010

Very limited evidence has been reported on host T cell responses to the pandemic H1N1 swine-origin influenza A virus (S-OIV) infection in humans. Therefore, we investigated the proportions of peripheral T cell subsets and analyzed the relationship of T helper subset changes with T cell activation during this infection. We found that these S-OIV-infected patients exhibited rapid lymphopenia, T cell activation and preferential loss of Th17 subset at the early stage of acute infection. Statistical analysis indicated that CD4 depletion and loss of Th17 cells, rather than Th1 or Treg cells, were correlated with CD4 T cell activation. More importantly, up-regulated IFN-α likely contributed to the functional loss of Th17 cells. Thus, rapidly generalized lymphopenia, preferential loss of Th17 population and T cell activation presented as characteristics of the early immune response in S-OIV-infected patients. These findings, therefore, may be helpful for an earlier diagnosis and further studies of immune pathogenesis of S-OIV infection. © 2010 Elsevier Inc. Source

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