PLA Institute of Disease Control and Prevention

Beijing, China

PLA Institute of Disease Control and Prevention

Beijing, China
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Chu C.-Y.,Beijing Institute of Microbiology and Epidemiology | Chu C.-Y.,PLA Institute of Disease Control and Prevention | Jiang B.-G.,Beijing Institute of Microbiology and Epidemiology | He J.,Beijing Institute of Microbiology and Epidemiology | And 10 more authors.
Vector-Borne and Zoonotic Diseases | Year: 2011

Thirty-two strains of Borrelia burgdorferi sensu lato were isolated from Ixodes persulcatus ticks collected from northeastern China from May to June in 2004 and 2005. Restriction fragment length polymorphism (RFLP) analysis and sequence analysis of 5S-23S rRNA intergenic spacer revealed that 29 (90.6%) belonged to Borrelia garinii, demonstrating B, C, and a unique pattern. The remaining three isolates (9.4%) were Borrelia afzelii with pattern D. The phylogenetic analysis based on 5S-23S rRNA intergenic spacer showed that B. garinii and B. afzelii genospecies clustered into two separate lineages. B. garinii strains were classified into three different branches: All the strains with RFLP pattern C were in the same branch, strain VH10 with a unique RFLP pattern clustered with strains VH9 and MDH2 with pattern B, and the rest of the strains with pattern B constitute another branch. These findings demonstrate the genetic diversity of B. burgdorferi sensu lato isolates from northeastern China. © 2011, Mary Ann Liebert, Inc.

Wang Y.,PLA Institute of Disease Control and Prevention | Zhang S.,Centers for Disease Control and Prevention | Yu J.,Chinese Institute of Basic Medical Sciences | Zhang H.,PLA Institute of Disease Control and Prevention | And 5 more authors.
Food Control | Year: 2010

We report an outbreak of food poisoning that occurred in August 2008 in a group of 13 persons who ate Stewed Pork Balls in Brown Sauce in Beijing. Epidemiology investigation and case-control analysis indicated that the Stewed Pork Balls in Brown Sauce was the source of food poisoning (OR 3.34, 95% CI 1.30-8.65). With the different measurements including API 20E and PCR, Dienes typing and PFGE, Proteus mirabilis was identified as a contributor to this matter, which evaluated by analyzing the collectives, which derived from contaminated food, patients, cook handlers and waiter. So this is the first report that P. mirabilis as a culprit resulted in food poisoning in Beijing. © 2009 Elsevier Ltd.

Wang L.,PLA Institute of Disease Control and Prevention | Xu Y.,PLA Institute of Disease Control and Prevention | Wang Y.,PLA Institute of Disease Control and Prevention | Dong S.,Centers for Disease Control and Prevention | And 10 more authors.
Food Control | Year: 2010

The objective of this research was to design and develop the Epidemiological Investigation and Intelligent Analytical System for foodborne disease to improve the ability to control foodborne disease events in field epidemiological investigations. The system is composed of standard electronic investigation questionnaires for collecting data from field investigations, a statistical analysis module integrated with statistically programmed methods for calculating odds and risk ratios for risk factors, an intelligent auxiliary diagnosis module featuring a feedback function able to enhance diagnostic accuracy, and a knowledge database for acquiring information in areas related to foodborne disease. The system has been provided to the People's Liberation Army Emergency Response Team for public health events. In field experiments, the system was very effective and improved work efficiency in epidemiological investigations of foodborne disease. © 2010.

Wang J.,China University of Mining and Technology | Cao Z.,CAS Institute of Automation | Wang Q.,Centers for Disease Control and Prevention | Wang X.,Centers for Disease Control and Prevention | Song H.,PLA Institute of Disease Control and Prevention
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2011

Based on the spatial units of community, village and town in Beijing, the relationship betweent HFMD morbidity and the potential risk factors has been examined. According to the 6 selected risk factors (namely population density, disposable income of urban residents, the number of medical and health institutions, the number of hospital beds, average annual temperature and average annual relative humidity) significantly related to HFMD morbidity, the prediction performance of Classical Linear Regression Model(CLRM) and Spatial Lag Model(SLM) has been compared. The results showed that SLM achieved better effect and R square reached 0.82. It was showed that spatial effect played the crucial role in the HFMD morbidity prediction and its contribution attained 88%. However, CLRM showed low prediction accuracy and bias estimation. It was demonstrated that including spatial effect item into CLRM could greatly improve the performance of HFMD morbidity prediciton model. © 2011 Springer-Verlag.

Vollmer S.A.,University of Bath | Feil E.J.,University of Bath | Chu C.-Y.,Beijing Institute of Microbiology and Epidemiology | Chu C.-Y.,PLA Institute of Disease Control and Prevention | And 4 more authors.
Infection, Genetics and Evolution | Year: 2013

The Lyme borreliosis (LB) group of spirochaetes currently comprises 18 named species that vary in their geographic distribution, host specificity and ability to cause disease in humans. In Europe three species are most abundant, Borrelia afzelii, Borrelia garinii and Borrelia valaisiana but only two of these (B. garinii and B. afzelii) are regularly found in Asia as well. A recently published study has shown that Borrelia species associated with birds, such as B. garinii, showed limited geographic structuring between European countries while, the rodent associated species, B. afzelii, showed extensive spatial structuring in Europe. Here, we use multilocus sequence analysis to show that when the wider, inter-continental, distribution is considered, there is evidence of spatial structuring even in the bird-associated species B. garinii. Furthermore, our investigations into historical LB populations provided evidence for range expansions of B. garinii and B. afzelii populations in Europe in the distant past. We propose that the expansion of B. afzelii in Europe may be linked to rodent population expansions after the last glacial maximum. © 2012 Elsevier B.V.

Jiang T.-J.,302 Hospital | Zhang J.-Y.,302 Hospital | Li W.-G.,302 Hospital | Xie Y.-X.,302 Hospital | And 5 more authors.
Clinical Immunology | Year: 2010

Very limited evidence has been reported on host T cell responses to the pandemic H1N1 swine-origin influenza A virus (S-OIV) infection in humans. Therefore, we investigated the proportions of peripheral T cell subsets and analyzed the relationship of T helper subset changes with T cell activation during this infection. We found that these S-OIV-infected patients exhibited rapid lymphopenia, T cell activation and preferential loss of Th17 subset at the early stage of acute infection. Statistical analysis indicated that CD4 depletion and loss of Th17 cells, rather than Th1 or Treg cells, were correlated with CD4 T cell activation. More importantly, up-regulated IFN-α likely contributed to the functional loss of Th17 cells. Thus, rapidly generalized lymphopenia, preferential loss of Th17 population and T cell activation presented as characteristics of the early immune response in S-OIV-infected patients. These findings, therefore, may be helpful for an earlier diagnosis and further studies of immune pathogenesis of S-OIV infection. © 2010 Elsevier Inc.

Wen L.,PLA Institute of Disease Control and Prevention | Li C.,PLA Institute of Disease Control and Prevention | Lin M.,Wanning Health and Epidemic Prevention Station | Yuan Z.,PLA Institute of Disease Control and Prevention | And 6 more authors.
Malaria Journal | Year: 2011

Background: Malaria incidence in China's Hainan province has dropped significantly, since Malaria Programme of China Global Fund Round 1 was launched. To lay a foundation for further studies to evaluate the efficacy of Malaria Programme and to help with public health planning and resource allocation in the future, the temporal and spatial variations of malaria epidemic are analysed and areas and seasons with a higher risk are identified at a fine geographic scale within a malaria endemic county in Hainan. Methods: Malaria cases among the residents in each of 37 villages within hyper-endemic areas of Wanning county in southeast Hainan from 2005 to 2009 were geo-coded at village level based on residence once the patients were diagnosed. Based on data so obtained, purely temporal, purely spatial and space-time scan statistics and geographic information systems (GIS) were employed to identify clusters of time, space and space-time with elevated proportions of malaria cases. Results: Purely temporal scan statistics suggested clusters in 2005,2006 and 2007 and no cluster in 2008 and 2009. Purely spatial clustering analyses pinpointed the most likely cluster as including three villages in 2005 and 2006 respectively, sixteen villages in 2007, nine villages in 2008, and five villages in 2009, and the south area of Nanqiao town as the most likely to have a significantly high occurrence of malaria. The space-time clustering analysis found the most likely cluster as including three villages in the south of Nanqiao town with a time frame from January 2005 to May 2007. Conclusions: Even in a small traditional malaria endemic area, malaria incidence has a significant spatial and temporal heterogeneity on the finer spatial and temporal scales. The scan statistics enable the description of this spatiotemporal heterogeneity, helping with clarifying the epidemiology of malaria and prioritizing the resource assignment and investigation of malaria on a finer geographical scale in endemic areas. © 2011 Wen et al; licensee BioMed Central Ltd.

Hao R.-Z.,Institute of Chemical Defence | Hao R.-Z.,PLA Institute of Disease Control and Prevention | Song H.-B.,PLA Institute of Disease Control and Prevention | Zuo G.-M.,Institute of Chemical Defence | And 7 more authors.
Biosensors and Bioelectronics | Year: 2011

The rapid detection of Bacillus anthracis, the causative agent of anthrax disease, has gained much attention since the anthrax spore bioterrorism attacks in the United States in 2001. In this work, a DNA probe functionalized quartz crystal microbalance (QCM) biosensor was developed to detect B. anthracis based on the recognition of its specific DNA sequences, i.e., the 168bp fragment of the Ba813 gene in chromosomes and the 340bp fragment of the pag gene in plasmid pXO1. A thiol DNA probe was immobilized onto the QCM gold surface through self-assembly via Au-S bond formation to hybridize with the target ss-DNA sequence obtained by asymmetric PCR. Hybridization between the target DNA and the DNA probe resulted in an increase in mass and a decrease in the resonance frequency of the QCM biosensor. Moreover, to amplify the signal, a thiol-DNA fragment complementary to the other end of the target DNA was functionalized with gold nanoparticles. The results indicate that the DNA probe functionalized QCM biosensor could specifically recognize the target DNA fragment of B. anthracis from that of its closest species, such as Bacillus thuringiensis, and that the limit of detection (LOD) reached 3.5×102CFU/ml of B. anthracis vegetative cells just after asymmetric PCR amplification, but without culture enrichment. The DNA probe functionalized QCM biosensor demonstrated stable, pollution-free, real-time sensing, and could find application in the rapid detection of B. anthracis. © 2011 Elsevier B.V.

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