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Yu S.,Chongqing Medical University | Gu J.,Chongqing Medical University | Wang H.G.,Chongqing Medical University | Wang Q.X.,PLA Chengdu Military Area Command General Hospital | And 7 more authors.
Clinical Immunology | Year: 2011

Enterohemorrhagic E. coli (EHEC) causes severe diseases in humans and animals via the production of Shiga toxins, and injection of effectors into epithelia using type III secretion system (TTSS). E. coli secreted protein A (EspA) forms the filamentous conduits of TTSS, which extends into the translocation pore embedded in host cell membranes and aids in the transportation of bacterial effectors. In addition, EspA is closely associated with initial bacterial adhesion and the formation of biofilms. EspA in its various forms elicits protective immune responses, although the epitope responsible has not to be identified. Here we report the presence of a linear, immunogenic, conserved and partially protective epitope E07 (100Lys-120Val) on EspA, which is recognized by the novel monoclonal antibody 1H10. This antibody blocks EHEC-induced actin polymerization and confers protection in mice. These findings provide a better understanding of EspA-induced immune responses and could lead to epitope-based vaccines and antibody-based therapies. © 2010 Elsevier Inc. Source


Zhang C.,PLA Chengdu Military Area Command General Hospital | Zhang C.,Sichuan University | Huang Z.,Sichuan University | Liao X.,Sichuan University | And 2 more authors.
Journal of Coatings Technology Research | Year: 2012

In this study, co-doped ZnO rod arrays with wurtzite crystal structure were successfully prepared on zinc substrate by the co-precipitation method. The results of crystal analysis indicated that the dopant Co 2+ was incorporated into ZnO crystal. Photoluminescence (PL) spectra and magnetization curves proved that their PL intensity and ferromagnetism were increased with the increase of Co 2+ concentrations in a ZnO host. Current-voltage characteristic curves of Co-doped ZnO rod arrays indicated that as-prepared samples were n-type semiconductors. Co-doped ZnO rod arrays could be envisioned to detect diseases and bacteria based on these properties. © 2012 ACA and OCCA. Source


Li Q.,PLA Chengdu Military Area Command General Hospital | Deng D.,PLA Chengdu Military Area Command General Hospital | Tao J.,PLA Chengdu Military Area Command General Hospital | Wu X.,PLA Chengdu Military Area Command General Hospital | And 3 more authors.
Genetics and Molecular Research | Year: 2015

We investigated wound tract extension of traumatic gunshot wounds in limb soft tissues as well as wound tract sonographic features and change-patterns when the limb position was changed. The experimental animals included 8 healthy crossbred pigs in the Chengdu plain region. Chinese Type 53 Carbine was used to establish the gunshot wound model of porcine soft tissues. Gunshot-injured zones in the soft tissues were dynamically observed at different time points using ultrasonic technology. Pathological examinations were performed for the corresponding regions for comparison and analysis. The internal echo of the wound tract was a pipe-like echo that changed over time. The wound tract extension changed with postural changes. The gas echo extended along the inside of the wound track, surrounding the fascia to further tissues. Ultrasonic imaging of gunshot wounds in pig soft tissues shows specific characteristics. The application of ultrasound technology may provide important imaging protection for gunshot wound debridement and postoperative unobstructed drainage, helping to improve the judgment and treatment of limb gunshot injuries. © FUNPEC-RP. Source

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