Dong G.-Z.,PLA 404 Central Hospital |
Du Z.-H.,PLA 404 Central Hospital |
Wang W.-D.,Chongqing Medical University |
Wang D.-G.,PLA 404 Central Hospital |
And 3 more authors.
Chinese Journal of Cancer Prevention and Treatment | Year: 2010
OBJECTIVE: To observe the sensitization effect, toxicity and survival rate of CMNa for patients who suffered from cervical cancer and recurred at cavitas pelvis after operative radiotherapy. METHODS: A total of 60 patients who suffered from cervical cancer and limited recurrence at cavitas pelvis after operative radiotherapy from January 2005 to April 2009 were divided into two groups according to the case and control method. The patients in the two groups both received three dimensional conformal radiation therapy while the sensitization group adding CMNa (800 mg/m2) for sensitization. The follow-up results of the two groups were compared. RESULTS: The tumor remission rate of patients in the sensitization group at post-radiotherapy 4 weeks, 6 weeks, 3 months and 12 months were 56.7%, 83.3%, 90.0% and 90.0% respectively, which had significant statistic difference compared with the control group (P<0.05). 1-year survival rate of patients in the sensitization group was 56.7%, while that was 26.7% in the control group which increased obviously and had significant statistic difference between the two groups. The patients in both groups had obvious analgesic effect and there was no significant difference in toxicity between two groups. CONCLUSION: CMNa has positive radiotherapy sensitization for patients with cervical cancer and recurred at cavitas pelvis after operation and radiotherapy.