Suzhou, China
Suzhou, China

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Wang Z.,Soochow University of China | Yu Z.,Soochow University of China | Su J.,Soochow University of China | Cao L.,Soochow University of China | And 7 more authors.
American Journal of Clinical Dermatology | Year: 2010

We report a typical case of hematidrosis in a Chinese girl who had experienced frequent bleeding episodes for more than 3 years. During hospitalization, spontaneous bleeding from her intact skin was witnessed by our staff on more than 20 occasions. Characteristically, bloody droplets from the intact skin contained all blood components. Histopathologic examination showed some inconspicuous abnormalities, with normal sweat gland structure containing no blood, and bloody exudate also came from some areas that do not contain sweat glands.Webelieve that the blood was mixed with a sweat-like fluid, rather than real sweat. The patient's bleeding problem was dramatically resolved by treatment with propranolol. We suggest that sympathetic nerve activation might play a role in these events, and that b-adrenoceptor antagonists might be an effective treatment for this disorder. © 2010 Adis Data Information BV. All rights reserved.


Shen H.,PLA 100th Hospital | Wang Z.,Soochow University of China | Wu T.,PLA 100th Hospital | Wang J.,PLA 100th Hospital | And 4 more authors.
Journal of International Medical Research | Year: 2015

The aetiology and pathological mechanisms involved in the development of haematidrosis (bloody sweat) remain unclear. There is no specific treatment for this disorder. This case report describes the clinical manifestations and treatment of a 9-year-old female with haematidrosis associated with epilepsy. The diagnosis of haematidrosis was confirmed by medical personnel who observed the bleeding and were able to rule out other causes of the bloody exudate. The episodes of bleeding were spontaneous, transient, and self-limited. Smears of the bloody exudate contained all of the components of peripheral blood. A skin biopsy taken at one site of the bloody exudate was normal, showing no signs of blood extravasation or bleeding sweat glands. The bleeding events were found to be immediately preceded by tonic seizures. An electroencephalogram indicated cerebral parietooccipital epilepsy, which was characterized by an intermittent medium-high amplitude θ rhythm (5–7 Hz) with a few spikes. The symptoms of both epilepsy and haematidrosis resolved after treatment with the antiepileptic drug 150 mg oxcarbazepine, orally, twice a day, which suggests that the epileptic seizures triggered haematidrosis in this patient. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav


Cui Q.,PLA 100th Hospital | Wu T.,PLA 100th Hospital | Chen H.,PLA 100th Hospital | Qin L.,PLA 100th Hospital | And 3 more authors.
Blood Coagulation and Fibrinolysis | Year: 2015

Chronic disseminated intravascular coagulation is a rare complication of aortic dissection. Surgical correction or low molecular weight heparin is treatment of choice, but for a severe bleeding problem due to excessive fibrinolysis, para-aminomethylbenzoic acid would be a simple and effective therapeutic approach. © 2015 Wolters Kluwer Health, Inc.


PubMed | PLA 100th Hospital and Soochow University of China
Type: Case Reports | Journal: The Journal of international medical research | Year: 2015

The aetiology and pathological mechanisms involved in the development of haematidrosis (bloody sweat) remain unclear. There is no specific treatment for this disorder. This case report describes the clinical manifestations and treatment of a 9-year-old female with haematidrosis associated with epilepsy. The diagnosis of haematidrosis was confirmed by medical personnel who observed the bleeding and were able to rule out other causes of the bloody exudate. The episodes of bleeding were spontaneous, transient, and self-limited. Smears of the bloody exudate contained all of the components of peripheral blood. A skin biopsy taken at one site of the bloody exudate was normal, showing no signs of blood extravasation or bleeding sweat glands. The bleeding events were found to be immediately preceded by tonic seizures. An electroencephalogram indicated cerebral parietooccipital epilepsy, which was characterized by an intermittent medium-high amplitude rhythm (5-7 Hz) with a few spikes. The symptoms of both epilepsy and haematidrosis resolved after treatment with the antiepileptic drug 150 mg oxcarbazepine, orally, twice a day, which suggests that the epileptic seizures triggered haematidrosis in this patient.


Jin L.-J.,PLA 100th Hospital | Chen H.-F.,PLA 100th Hospital | Wu T.-Q.,PLA 100th Hospital | Tang J.-Q.,PLA 100th Hospital | And 5 more authors.
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi | Year: 2010

OBJECTIVE: To investigate the pathology, diagnosis and treatment of a patient with hemotidrosis.METHODS: Coagulation tests, coagulation factor activities, von Willebrand factor concentration, bleeding time and platelet aggregation were measured. The bloody exudates from the skin was examined under light microscopy. The involved skin area biopsy was examined histologically.RESULTS: The bloody exudates contained all kinds of normal blood cells mixed with sweat-like fluid, rather than true-sweat. Histopathologic examination showed normal sweat gland structure without blood cells. The patient was successfully treated with propranolol.CONCLUSION: Sympathetic nerve activation in the vasculature might play a role in hemotidrasis, and beta-blockers might be an effective drug for treatment.


PubMed | PLA 100th Hospital
Type: Journal Article | Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi | Year: 2010

To investigate the pathology, diagnosis and treatment of a patient with hemotidrosis.Coagulation tests, coagulation factor activities, von Willebrand factor concentration, bleeding time and platelet aggregation were measured. The bloody exudates from the skin was examined under light microscopy. The involved skin area biopsy was examined histologically.The bloody exudates contained all kinds of normal blood cells mixed with sweat-like fluid, rather than true-sweat. Histopathologic examination showed normal sweat gland structure without blood cells. The patient was successfully treated with propranolol.Sympathetic nerve activation in the vasculature might play a role in hemotidrasis, and beta-blockers might be an effective drug for treatment.

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