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Sahoo R.,University Sidi Mohammed Ben Abdellah | Sahoo S.,Melaka Manipal Medical College | Nayak P.L.,Pl Nayak Research Foundation
European Journal of Scientific Research | Year: 2010

In this present research program, mucoadhesive polymer tamarind seed polysaccharide (TSP) "galactoxyloglucan" has been used as the drug carrier for delivery systems of anticancer drug, paclitaxel (PTX) with different concentrations for studying the in-vitro drug delivery systems. The structure characterization of polymer-drug composites were investigated by Fourier Transform Infrared Spectra (FTIR), Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA) and X-Ray Diffraction (XRD) Respectively, the drug release was studied by changing time, pH and drug concentrations. The kinetics of the drug release was studied in order to ascertain the type of release mechanism. Based on the diffusion as well as the kinetics, the mechanism of the drug release from the composite matrix has been reported. © EuroJournals Publishing, Inc. 2010. Source


Sahoo D.,Pl Nayak Research Foundation | Nayak P.L.,Pl Nayak Research Foundation
International Journal of Materials Research | Year: 2012

Gelatin-Cloisite 30B (C 30B) hybrid nano-composites were prepared by blending gelatin with cloisite 30B in aqueous solution. The nano-composites were characterized by using FTIR, SEM and XRD analysis. From the FTIR spectra the various groups present in the gelatin blend were monitored. The homogeneity, morphology and crystallinity of the blends were ascertained from SEM and XRD data, respectively. The results indicate that an intercalated or partially exfoliated nano-composite can be achieved, and the properties of the composite are significantly improved. The drug release kinetics was investigated using ofloxacin as the drug. The kinetics of the drug delivery system was systematically studied. Drug release kinetics was analyzed by plotting the cumulative release data vs. time by fitting to an exponential equation which indicates the non-Fickian type of kinetics. The drug release was investigated at different pH medium and it was found that the drug release depends upon the pH medium as well as the nature of the matrix. © 2012 Carl Hanser Verlag GmbH & Co. KG. Source


Dash M.P.,Pl Nayak Research Foundation | Sasmal A.,Pl Nayak Research Foundation | Mohanty G.C.,Ravenshaw University | Nayak P.L.,Pl Nayak Research Foundation
Journal of Materials Science | Year: 2010

In this research article, we have described the synthesis of acid (HCl)-doped poly(anthranilic acid) (PAA) with carboxylic groups containing multi-walled carbon nanotubes (c-MWNTs) via in situ polymerization. Anthranilic acid monomers were adsorbed on the surface of MWNTs and polymerized to form PAA/c-MWNT composites. The structure of PAA/c-MWNT composites was characterized by UV-vis spectra, Fourier transform infrared spectroscopy, nuclear magnetic resonance, and X-ray diffraction patterns. Scanning electron microscopy and transmission electron microscopy images showed that both the thinner fibrous phase and the larger block phase could be observed. The individual fibrous phases had diameters of about 100 nm, and therefore, must be the carbon nanotubes (diameter 10-20 nm) coated by a PAA layer. The electrical conductivities of PAA/c-MWNT increased with the increase of c-MWNT content. © 2010 Springer Science+Business Media, LLC. Source


Nanda R.,Pl Nayak Research Foundation | Sasmal A.,Pl Nayak Research Foundation | Nayak P.L.,Pl Nayak Research Foundation
Carbohydrate Polymers | Year: 2011

Chitosan (CS) and polylactide (PLA) at different ratios were blended with different wt% of montmorillonite (MMT) (Cloisite 30B) solution by the solvent evaporation method. MMT was incorporated in the formulation as a matrix material component which also plays the role of a co-emulsifier in the nanocomposite preparation. Paclitaxel (PTX) with different concentrations was loaded with CS-PLA/MMT nanocomposites for studying in vitro drug delivery systems. The composites were characterized by FTIR, SEM, and XRD methods. The drug release was studied as a function of, pH and drug concentrations. The kinetics of the drug release was studied in order to ascertain the type of release mechanism. Based on the diffusion as well as the kinetics, the mechanism of the drug release from the composite matrix has been reported. © 2010 Elsevier Ltd. All rights reserved. Source


Sahoo S.,Pl Nayak Research Foundation | Sasmal A.,Pl Nayak Research Foundation | Sahoo D.,Pl Nayak Research Foundation | Nayak P.,Pl Nayak Research Foundation
Journal of Applied Polymer Science | Year: 2010

In the present research program, chitosan has been mixed with polycaprolactone (PCL) (80:20) for using them for control delivery of doxycycline. Organoclay, Cloisite 30B of different concentrations 1, 2.5, and 5% has been blended with the composite. Chitosan is a natural biodegradable polymer where as polycaprolactone is a synthetic biopolymer. The blending of the two polymers has been carried out varying the proportion of nanoclay so that the composite can be a better drug carrier. The blends were characterized by Fourier Transmission Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), X-ray Diffraction (XRD) analysis. From the FTIR spectra, the various groups present in chitosan and PCL blend were monitored. The homogeneity, morphology, and crystallinity of the blends were ascertained from SEM and XRD data, respectively. The swelling studies have been carried out at different drug loading. Swelling study is an important parameter to predict the diffusion of the drugs from the matrix. The kinetics of the drug delivery system has been systematically studied. Drug release kinetics was analyzed by plotting the cumulative release data versus time by fitting to an exponential equation which indicated the non-Fickian type of kinetics. The drug release was investigated at different pH medium, and it was found that the drug release depends upon the pH medium as well as the nature of matrix. © 2010 Wiley Periodicals, Inc. Source

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