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Zagoriy G.,PJSC Pharmaceutical company Darnitsa | Zayarnyuk N.,Lviv Polytechnic | Sobetov B.,Lviv Polytechnic | Krychkovska A.,Lviv Polytechnic | And 6 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

New injectable combined prolonged drug "Naltetlong" containing disulfiram and naltrexone was developed. An optimal pharmaceutical form and polymers-prolongers with a certain molecular weight were chosen based on experimental research. Conditions of interaction of the polymer-carrier of active substances for saving molecules structures of drugs components and formation of particles in the nanospheres form with a uniform size distribution were proposed. Uniform distribution size provides the prolongation of drug activity. The predictable product performance was identified and was equal to 30 days. Preclinical studies of toxicity and specific activity of the combined preparation "Naltetlong" indicate a pronounced pharmacological activity and moderate toxicity. Preliminary data on the use of "Naltetlong" in the treatment of alcohol and drug addiction have shown the prospects of its application for the treatment and rehabilitation of patients.

Polovkovych S.,Lviv Polytechnic | Zagoriy G.,PJSC Pharmaceutical company Darnitsa | Bondarchuk O.,Lviv Polytechnic | Vynnytska R.,Lviv Polytechnic | And 7 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

The properties of 1,4-quinoid compounds in reactions with electrophilic and nucleophilic agents were studied. Heterocyclization of 1,4-quinone derivatives with furan, 1-methyl-2-pirydon and 5-arylmethyliden-4-thioxo-2-thiazolidones by Diels-Alder reaction was carried out. New condensed polyheterocyclic compounds were synthesized through interaction of 2,3-dichloro-1,4-naphthoquinone with several heteroderivatives of hydrazine and with their subsequent cyclization. Quantum-mechanical calculations for compounds-substrates by means of computer modeling were carried out. By in silico studies the possibility of displaying biological activity of synthesized compounds was predicted.

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