Time filter

Source Type

Hammoudi N.,Pitie Salpetriere Hospital Groupe Hospitalier Pitie Salpetriere | Hammoudi N.,University Pierre and Marie Curie | Arangalage D.,Pitie Salpetriere Hospital Groupe Hospitalier Pitie Salpetriere | Djebbar M.,Pitie Salpetriere Hospital Groupe Hospitalier Pitie Salpetriere | And 11 more authors.
International Journal of Cardiovascular Imaging | Year: 2014

Chronic volume overload in sickle-cell anemia (SCA) is associated with left ventricular (LV) enlargement and hypertrophy. The effect of the disease on LV systolic function remains debated. The aim of our study was to investigate LV systolic function in SCA patients using 2D speckle-tracking imaging. We compared 30 steady state asymptomatic adult SCA patients (17 women, mean age 24.7 ± 5.1 years) with 30 age and sex-matched healthy subjects (17 women, mean age 25.0 ± 4.9 years). In addition to conventional echocardiographic parameters including LV ejection fraction (LVEF) and LV mass index (LVMi), global longitudinal strain (GLS) and strain rate (GLSR) were measured. GLS (−17.9 ± 2.0 vs. −19.7 ± 2.5 %, p = 0.004) and GLSR (−0.92 ± 0.09 vs. −1.07 ± 0.17 s−1, p < 0.0001) values were lower in SCA patients while LVEF values (60.1 ± 3.8 vs. 61.7 ± 4.7 %, p = 0.30) were not different. LVMi was increased in SCA patients (100.7 ± 23.5 vs. 72.4 ± 15.2 g/m2, p = 0.0001) and GLSR was significantly lower in the subgroup of patients with LV hypertrophy (−0.88 ± 0.09 vs. −0.96 ± 0.08 s−1, p = 0.02). In SCA patients LVMi was correlated to GLS (r = 0.58, p = 0.001) and GLSR (r = 0.45, p = 0.015) pleading in favor of a pathological LV remodeling. Asymptomatic SCA patients exhibited a subclinical alteration of LV systolic function. Myocardial dysfunction appears to be linked to the degree of LV hypertrophy. 2D speckle-tracking imaging might be useful for long-term follow-up and to study the natural course of LV dysfunction in SCA patients. © 2014, Springer Science+Business Media Dordrecht.


Bachelot A.,Pitie Salpetriere Hospital Groupe Hospitalier Pitie Salpetriere | Chakhtoura Z.,Pitie Salpetriere Hospital Groupe Hospitalier Pitie Salpetriere | Plu-Bureau G.,University of Paris Descartes | Coudert M.,Pitie Salpetriere Hospital | And 5 more authors.
European Journal of Endocrinology | Year: 2012

Objective: Women with classical congenital adrenal hyperplasia (CAH) exhibit reduced fertility due to several factors including anovulation. This has been attributed to a disturbed gonadotropic axis as in polycystic ovary syndrome (PCOS), but there is no precise evaluation. Our aim was to evaluate the gonadotropic axis and LH pulsatility patterns and to determine factor(s) that could account for the potential abnormality of LH pulsatility. Design: Case/control study. Methods: Sixteen CAH women (11 with the salt-wasting form and five with the simple virilizing form), aged from 18 to 40 years, and 16 age-matched women, with regular menstrual cycles (28 ± 3 days), were included. LH pulse patterns over 6 h were determined in patients and controls. Results: No differences were observed between patients and controls in terms of mean LH levels, LH pulse amplitude, or LH frequency. In CAH patients, LH pulsatility patterns were heterogeneous, leading us to perform a clustering analysis of LH data, resulting in a two-cluster partition. Patients in cluster 1 had similar LH pulsatility patterns to the controls. Patients in cluster 2 had: lower LH pulse amplitude and frequency and presented menstrual cycle disturbances more frequently; higher 17-OH progesterone, testosterone, progesterone, and androstenedione levels; and lower FSH levels. Conclusions: LH pulsatility may be normal in CAH women well controlled by hormonal treatment. Undertreatment is responsible for hypogonadotropic hypogonadism, with low LH pulse levels and frequency, but not PCOS. Suppression of progesterone and androgen concentrations during the follicular phase of the menstrual cycle should be a major objective in these patients. © 2012 European Society of Endocrinology.


Hammoudi N.,Pitie Salpetriere Hospital Groupe Hospitalier Pitie Salpetriere | Hammoudi N.,University Paris - Sud | Ihaddaden M.,Ambroise Pare Hospital | Ihaddaden M.,University of Versailles | And 10 more authors.
International Journal of Cardiovascular Imaging | Year: 2014

Transesophageal echocardiography (TEE) is an efficient method for characterization of aortic atherosclerotic plaques (AAP). The aim of our study was to evaluate the feasibility and the additional contribution of three-dimensional (3D) TEE in the evaluation of AAPs in descending thoracic aorta. We studied 82 patients referred for TEE regardless of the indication. All patients underwent two-dimensional (2D) conventional acquisitions. A 3D TEE study was performed for all AAPs localized in the descending thoracic aorta. Thickness, degree of calcification, the presence of ulceration or mobile debris were compared for 2D and 3D modes. From 3D data, three types of AAPs were defined according to their morphological characteristics (surface and contours). Among 192 AAPs found on 2D acquisition, 189 (98.4 %) were also identified by 3D TEE. For AAP characterization, agreement was good between 2D TEE and 2D extracted from 3D with the multiplanar reconstruction mode: 83.6 % (k = 0.69) for thickness and 82.5 % (k = 0.72) for degree of calcification. All AAPs ulcerations (n = 13) and mobile debris (n = 3) seen in 2D were identified in 3D. 2D characteristics of the 3D AAPs’ morphological types were different: type I plaques were thin and rarely calcified; type III plaques were thicker and often calcified; and type II presented intermediate characteristics. There was overlap among groups and the 3D morphology could not be predicted from 2D data. 3D TEE is a feasible method for the analysis of AAPs. In addition to conventional characterization, 3D TEE provides a new morphological approach to AAPs. © 2014, Springer Science+Business Media Dordrecht.


PubMed | Pitie Salpetriere Hospital Groupe Hospitalier Pitie Salpetriere
Type: Journal Article | Journal: The international journal of cardiovascular imaging | Year: 2014

Chronic volume overload in sickle-cell anemia (SCA) is associated with left ventricular (LV) enlargement and hypertrophy. The effect of the disease on LV systolic function remains debated. The aim of our study was to investigate LV systolic function in SCA patients using 2D speckle-tracking imaging. We compared 30 steady state asymptomatic adult SCA patients (17 women, mean age 24.7 5.1 years) with 30 age and sex-matched healthy subjects (17 women, mean age 25.0 4.9 years). In addition to conventional echocardiographic parameters including LV ejection fraction (LVEF) and LV mass index (LVMi), global longitudinal strain (GLS) and strain rate (GLSR) were measured. GLS (-17.9 2.0 vs. -19.7 2.5 %, p = 0.004) and GLSR (-0.92 0.09 vs. -1.07 0.17 s(-1), p < 0.0001) values were lower in SCA patients while LVEF values (60.1 3.8 vs. 61.7 4.7 %, p = 0.30) were not different. LVMi was increased in SCA patients (100.7 23.5 vs. 72.4 15.2 g/m(2), p = 0.0001) and GLSR was significantly lower in the subgroup of patients with LV hypertrophy (-0.88 0.09 vs. -0.96 0.08 s(-1), p = 0.02). In SCA patients LVMi was correlated to GLS (r = 0.58, p = 0.001) and GLSR (r = 0.45, p = 0.015) pleading in favor of a pathological LV remodeling. Asymptomatic SCA patients exhibited a subclinical alteration of LV systolic function. Myocardial dysfunction appears to be linked to the degree of LV hypertrophy. 2D speckle-tracking imaging might be useful for long-term follow-up and to study the natural course of LV dysfunction in SCA patients.

Loading Pitie Salpetriere Hospital Groupe Hospitalier Pitie Salpetriere collaborators
Loading Pitie Salpetriere Hospital Groupe Hospitalier Pitie Salpetriere collaborators