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Haryana, India

Esakkidurai T.,Devanga Arts College Autonomous | Subbaraj P.,Devanga Arts College Autonomous | Shobana S.,Pioneer India
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2013

Mixed ligand Cu(ii) complexes of 2-aminobenzamide (2AB) and amino acids viz., glycine (gly), L-alanine (ala), L-valine (val) and L-phenylalanine (phe) have been synthesised and characterized by various physico-chemical and spectral techniques. The calculated g-tensor values for Cu(ii) complexes at 77 K and 300 K, show the distorted octahedral geometry which has been confirmed from the absorption studies. Consequently, the thermal studies illustrate that the loss of water and acetate molecules in the initial stage which are followed by the decomposition of organic residues. The powder X-ray diffraction and SEM analysis reflect that all the complexes have well-defined crystallinity nature with homogeneous morphology. The binding activities of CT DNA with CuAB complexes have been examined by absorption studies. Further, the oxidative cleavage Interactions of 2-aminobenzamide and CuAB complexes with DNA were studied by gel electrophoresis method in H2O2 medium. Also, the complex formation of Cu(ii) involving 2-aminobenzamide and amino acids were carried out by a combined pH-metric and spectro-photometric techniques in 50% (v/v) water-ethanol mixture at 300, 310, 320 and 330±0.1 K with i= 0.15 mol dm 3 (NaClO4). in solution, CuAB and CuAB2 species has been detected and the binding modes of 2-aminobenzamide and amino acids in both binary and mixed ligand complexes are same. The calculated stabilization value of δ log K, log X and log X′ indicates higher stabilities for the mixed ligand complexes rather than their binary species. The thermodynamic parameters like δG, DH and DS have been determined from temperature dependence of the stability constant. in vitro biological activities of 2-aminobenzamide, CuA and CuAB complexes show remarkable activities against some bacterial and fungal strains. The percentage distribution of various binary and mixed ligand species in solution at dissimilar pH intervals were also evaluated. © 2013 Elsevier B.V. All rights reserved. Source


Chothani D.L.,Pioneer India | Vaghasiya H.U.,Sun Pharma Advanced Research Company SPARC Ltd.
Pharmacognosy Reviews | Year: 2011

Balanites aegyptiaca Del. (Zygophyllaceae), known as 'desert date,' is spiny shrub or tree up to l0 m tall, widely distributed in dry land areas of Africa and South Asia. It is traditionally used in treatment of various ailments i.e. jaundice, intestinal worm infection, wounds, malaria, syphilis, epilepsy, dysentery, constipation, diarrhea, hemorrhoid, stomach aches, asthma, and fever. It contains protein, lipid, carbohydrate, alkaloid, saponin, flavonoid, and organic acid. Present review summarizes the traditional claims, phytochemistry, and pharmacology of B. aegyptiaca Del reported in scientific literature. Source


Shah U.,Pioneer India
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011

Cissus quadrangularis L. is a succulent plant of family Vitaceae commonly found in tropical and subtropical xeric wood. It is a fleshy, cactus-like liana widely used as a common food item in India. The plant is prescribed in the ancient Ayurvedic literature as a general tonic and analgesic, with specific bone fracture healing properties. The plant is believed to be useful in helminthiasis, anorexia, dyspepsia, colic, flatulence, skin diseases, leprosy, hemorrhage, epilepsy, convulsion, haemoptysis, tumors, chronic ulcers, swellings. Following various folk claims for cure of various diseases, efforts have been made by researchers to verify the efficacy of the plant through scientific biological screening. The scrutiny of literature revealed some notable pharmacological activities of the plant such as antioxidant, free radical scavenging, anti microbial, anti bacterial, bone healing, anti ulcer, analgesic, anti inflammatory and diuretic, presented in this review such that the potential use of the plant either in pharmaceutics or as an agriculture resource can be evaluated. The present review is an attempt to highlight phytochemicals, various traditional uses as well as pharmacological reports on Cissus quadrangularis L. Source


Gondalia R.P.,Atmiya Institute of Pharmacy | Dharamsi A.P.,Pioneer India
Asian Journal of Pharmaceutical and Clinical Research | Year: 2011

A binary mixture of Naproxen sodium and Sumatriptan succinate was determined by UV spectroscopic methods. The method involved determination of NAP and SUMA using the first derivative spectrophotometry at 241.0 and 236.0 nm over the concentration ranges of 0.5-3.5 μg/ml for both. The methods were successively applied to pharmaceutical formulation because no Spectroscopic interferences from the tablet excipients were found. The suitability of these methods for the quantitative determination of the compounds was proved by validation. Source


Patel D.J.,Pioneer India | Patel V.P.,Sun Pharmaceutical Industries Ltd.
International Journal of ChemTech Research | Year: 2010

A simple, rapid and accurate High-performance thin-layer chromatography (HPTLC) method has been established and validated for the simultaneous determination of paracetamol and lornoxicam in tablets. The method is based on HPTLC separation of the two drugs followed by densitometric measurements of their spots at 270 nm. The separation was carried out on Merck TLC aluminium sheets of silica gel 60F-254 using ethyl acetate: methanol: toluene: glacial acetic acid (7:2.5:1:0.5, v/v/v/v) as a mobile phase. Calibration curves were linear in range of 200- 1200 ng/spot and 100 - 600 ng/spot for paracetamol and lornoxicam, respectively. Method was successively applied to tablet formulation. No chromatographic interferences from the tablet excipients were found. The method was validated in accordance with the requirements of ICH guidelines. Source

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