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Singh J.,Health Science University | Desai S.,Pioneer India | Yadav S.,Md University | Narasimhan B.,Md University | Kaur H.,Md University
Current Pharmaceutical Design | Year: 2016

During the past decade, the arena of polymer therapeutics has acquired considerable interest and accompanied by advanced designs and chemical properties of polymer-drug conjugates. Various polymers, such as poly (ethylene glycol) (PEG), N-(2-hydroxypropyl) methacrylamide (HPMA), poly(glycolic acid) (PGA) and poly(lactide-co-glycolide) (PLGA) have been used successfully for clinical utilization from decades. These polymers are used in combination of drugs in such a manner that they target the specific tissues and thus the toxicity of drugs to other tissues is reduced. Presently, numerous polymer drug conjugates are under clinical trial for treatment of various diseases including cancer, diabetes, AIDS, rheumatoid arthritis etc. Many protein-polymer conjugates have been approved by FDA for clinical use but till date, no polymer-synthetic drug conjugate is approved by FDA, although many of them are undergoing final phase of clinical trials. This review highlights the recent advancements in the polymer-drug conjugates for treatment of various diseases and their preclinical and clinical status. © 2016 Bentham Science Publishers.

Acharya N.,Nirma University | Acharya S.,Nirma University | Shah U.,Pioneer India | Shah R.,Sun Pharma Advanced Research Center | Hingorani L.,Pharmanza Herbal Pvt. Ltd.
Journal of Ethnopharmacology | Year: 2016

Ethnopharmacological relevance Symplocos racemosa Roxb. belongs to a unigeneric family Symplocaceae, known as lodhra in Sanskrit; is a small evergreen tree, found throughout the tropical and sub-tropical countries. Ethnobotanical literature indicates use of S. racemosa in treatment of eye disease, skin diseases, ear diseases, liver and bowel complaints, tumors, uterine disorders, spongy and bleeding gums, asthma, fever, snake-bite, gonorrhea and arthritis. The main aim of this review is to provide detailed phytopharmacological profile on S. racemosa in support with the traditional practices and ethnomedicinal uses. Materials and methods All relevant worldwide accepted databases have been searched for the name "S. racemosa" along with other literature from Indian Classical texts and Pharmacopoeias. The accessible literatures available on S. racemosa, were collected through electronic search on Pub med, Scopus, Science direct and traditional reports. Results S. racemosa is important Indian traditional drug used in many Ayurvedic and herbal formulations for treatment of liver as well as uterine disorders and leucorrhea. Majority of phytopharmacological reports are on stem bark of the plant which include anti-cancer, hepatoprotective, anti-oxidant, anti-androgenic effect, anti-inflammatory, wound healing activity and anti-diabetic effects. Phytochemical studies indicated presence of many phenolic glycosides like symplocoside, triterpenoids like betulinic acid, acetyloleanolic acid and oleanolic acid and flavonoids like quercetin which might have contributed to the observed protective effects. Conclusion Many ethnobotanical claims have been confirmed through systematic in-vitro and in-vivo pharmacological studies on different extracts of stem bark and isolated constituents. However, systematic studies on the bio-markers are desirable to establish mode of action and to validate the traditional claim in clinical practice after proper safety assessment. The conservation data of genus Symplocos showed risk of extinction due to restricted distribution in the wild hence systematic techniques should be developed for the maintenance of this plant. © 2016 Elsevier Ireland Ltd.

Esakkidurai T.,Devanga Arts College Autonomous | Subbaraj P.,Devanga Arts College Autonomous | Shobana S.,Pioneer India
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2013

Mixed ligand Cu(ii) complexes of 2-aminobenzamide (2AB) and amino acids viz., glycine (gly), L-alanine (ala), L-valine (val) and L-phenylalanine (phe) have been synthesised and characterized by various physico-chemical and spectral techniques. The calculated g-tensor values for Cu(ii) complexes at 77 K and 300 K, show the distorted octahedral geometry which has been confirmed from the absorption studies. Consequently, the thermal studies illustrate that the loss of water and acetate molecules in the initial stage which are followed by the decomposition of organic residues. The powder X-ray diffraction and SEM analysis reflect that all the complexes have well-defined crystallinity nature with homogeneous morphology. The binding activities of CT DNA with CuAB complexes have been examined by absorption studies. Further, the oxidative cleavage Interactions of 2-aminobenzamide and CuAB complexes with DNA were studied by gel electrophoresis method in H2O2 medium. Also, the complex formation of Cu(ii) involving 2-aminobenzamide and amino acids were carried out by a combined pH-metric and spectro-photometric techniques in 50% (v/v) water-ethanol mixture at 300, 310, 320 and 330±0.1 K with i= 0.15 mol dm 3 (NaClO4). in solution, CuAB and CuAB2 species has been detected and the binding modes of 2-aminobenzamide and amino acids in both binary and mixed ligand complexes are same. The calculated stabilization value of δ log K, log X and log X′ indicates higher stabilities for the mixed ligand complexes rather than their binary species. The thermodynamic parameters like δG, DH and DS have been determined from temperature dependence of the stability constant. in vitro biological activities of 2-aminobenzamide, CuA and CuAB complexes show remarkable activities against some bacterial and fungal strains. The percentage distribution of various binary and mixed ligand species in solution at dissimilar pH intervals were also evaluated. © 2013 Elsevier B.V. All rights reserved.

Patel P.,Pioneer India | Varshney P.,Pioneer India | Rohit M.,Pioneer India
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Two simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of metronidazole and amoxicillin in combined dosage form have been developed. First method employs formation and solving of simultaneous equation using 320 nm and 273 nm as two analytical wavelengths for both drugs in distilled water. The second method is a Q value analysis based on measurement of absorptivity at 320nm and 228nm (as anISO-absorptive point). Metronidazole and amoxicillin at their respective λmax 320 nm and 273 nm and at iso-absorptive point 228 nm shows linearity in a concentration range of 10-30 μg/mL. The results of the analysis have been validated statistically, the relative standard deviation lies in the range of 1.11 - 1.25 for amoxicillin and 1.05 - 1.19 for metronidazole in case of simultaneous equation method and 0.41-1.11formetronidazole and 0.51-1.23 in the case of Q - analysis method.

Gondalia R.P.,Atmiya Institute Of Pharmacy | Dharamsi A.P.,Pioneer India
Asian Journal of Pharmaceutical and Clinical Research | Year: 2011

A binary mixture of Naproxen sodium and Sumatriptan succinate was determined by UV spectroscopic methods. The method involved determination of NAP and SUMA using the first derivative spectrophotometry at 241.0 and 236.0 nm over the concentration ranges of 0.5-3.5 μg/ml for both. The methods were successively applied to pharmaceutical formulation because no Spectroscopic interferences from the tablet excipients were found. The suitability of these methods for the quantitative determination of the compounds was proved by validation.

Shah U.,Pioneer India | Shah R.,Sun Pharma Advanced Research Center | Acharya S.,Nirma University | Acharya N.,Nirma University
Chinese Journal of Natural Medicines | Year: 2013

Plants remain an important source of new drugs, new drug leads and new chemical entities. Plant based drug discovery resulted mainly in the development of anticancer and anti-infectious agents, and continues to contribute to the new leads in clinical trials. Natural product drugs play a dominant role in pharmaceutical care. Several plant-derived compounds are currently successfully employed in cancer treatment. There are many classes of plant-derived cytotoxic natural products studied for further improvement and development of drugs. New anticancer drugs derived from research on plant antitumor agents will be continuously discovered. The basic aim of this review is to explore the potential of newly discovered anticancer compounds from medicinal plants, as a lead for anticancer drug development. It will be helpful to explore the medicinal value of plants and for new drug discovery from them for the researchers and scientists around the globe. © 2013 China Pharmaceutical University.

Joshi A.,Indian Defence Institute of Advanced Technology | Bajaj A.,Indian Defence Institute of Advanced Technology | Singh R.,Indian Defence Institute of Advanced Technology | Anand A.,Pioneer India | And 2 more authors.
Composites Part B: Engineering | Year: 2015

The advent of graphene heralded by the recent studies on carbon based conducting polymer composites has been a motivation for the use of graphene as an electromagnetic interference (EMI) shielding material. One of the variants of graphene, graphene nanoribbon (GNR) shows remarkably different properties from graphene. The EMI shielding effectiveness of the composite material mainly depends on fillers' intrinsic conductivity, dielectric constant and aspect ratio. We have synthesized graphene nanoribbon (GNR) - Polyaniline (PANI) - epoxy composite film for effective shielding material in the X-band frequency range of 8.2-12.4 (GHz). We have performed detailed studies of the EMI shielding effect and the performance of the composite and found that the composite shows ∼-40 dB shielding which is sufficient to shield more than 95% of the EM waves in X Band. We checked the shielding effectiveness of the composite film by varying the GNR percentage and the thickness of the film. The strength properties of the synthesized composited were also studied with a aim to have a material having both high strength and EMI shielding properties. © 2014 Elsevier Inc. All rights reserved.

Patel D.J.,Pioneer India | Patel V.P.,Sun Pharmaceutical Industries LTD
International Journal of ChemTech Research | Year: 2010

A simple, rapid and accurate High-performance thin-layer chromatography (HPTLC) method has been established and validated for the simultaneous determination of paracetamol and lornoxicam in tablets. The method is based on HPTLC separation of the two drugs followed by densitometric measurements of their spots at 270 nm. The separation was carried out on Merck TLC aluminium sheets of silica gel 60F-254 using ethyl acetate: methanol: toluene: glacial acetic acid (7:2.5:1:0.5, v/v/v/v) as a mobile phase. Calibration curves were linear in range of 200- 1200 ng/spot and 100 - 600 ng/spot for paracetamol and lornoxicam, respectively. Method was successively applied to tablet formulation. No chromatographic interferences from the tablet excipients were found. The method was validated in accordance with the requirements of ICH guidelines.

Chothani D.L.,Pioneer India | Vaghasiya H.U.,Sun Pharma Advanced Research Company SPARC Ltd.
Pharmacognosy Reviews | Year: 2011

Balanites aegyptiaca Del. (Zygophyllaceae), known as 'desert date,' is spiny shrub or tree up to l0 m tall, widely distributed in dry land areas of Africa and South Asia. It is traditionally used in treatment of various ailments i.e. jaundice, intestinal worm infection, wounds, malaria, syphilis, epilepsy, dysentery, constipation, diarrhea, hemorrhoid, stomach aches, asthma, and fever. It contains protein, lipid, carbohydrate, alkaloid, saponin, flavonoid, and organic acid. Present review summarizes the traditional claims, phytochemistry, and pharmacology of B. aegyptiaca Del reported in scientific literature.

Shah U.,Pioneer India
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011

Cissus quadrangularis L. is a succulent plant of family Vitaceae commonly found in tropical and subtropical xeric wood. It is a fleshy, cactus-like liana widely used as a common food item in India. The plant is prescribed in the ancient Ayurvedic literature as a general tonic and analgesic, with specific bone fracture healing properties. The plant is believed to be useful in helminthiasis, anorexia, dyspepsia, colic, flatulence, skin diseases, leprosy, hemorrhage, epilepsy, convulsion, haemoptysis, tumors, chronic ulcers, swellings. Following various folk claims for cure of various diseases, efforts have been made by researchers to verify the efficacy of the plant through scientific biological screening. The scrutiny of literature revealed some notable pharmacological activities of the plant such as antioxidant, free radical scavenging, anti microbial, anti bacterial, bone healing, anti ulcer, analgesic, anti inflammatory and diuretic, presented in this review such that the potential use of the plant either in pharmaceutics or as an agriculture resource can be evaluated. The present review is an attempt to highlight phytochemicals, various traditional uses as well as pharmacological reports on Cissus quadrangularis L.

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