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Pingtung, Taiwan

Lu I.-C.,E DA Hospital | Yen Jean M.-C.,E DA Hospital | Yen Jean M.-C.,I - Shou University | Lei S.-M.,E DA Hospital | And 3 more authors.
Quality of Life Research | Year: 2011

Purpose: This study aims to evaluate and quantify the possible effect of psychological symptoms on healthy workers' quality of life (QOL). Methods: The workers were recruited from a factory in south Taiwan. We assessed their psychological symptoms with a 5-item brief symptom rating scale (BSRS-5) and measured the QOL using the Taiwanese version of the World Health Organization Quality of Life (WHOQOL)- BREF. Multiple linear regression analysis was conducted to explore the association between the two tools after control of confounding by other predictors. Results: A total of 1,080 workers, who attended a physical examination, completed questionnaires and informed consent forms. Scores on the BSRS-5 significantly predicted scores in each domain and items of the WHOQOL-BREF. The magnitude of psychological domain score seemed to be affected the most; every 1 point increase in BSRS-5 was associated with a 0.39 raw score (equivalent to 2.44 percentile) decrease in QOL. The sleep facet of WHOQOL appeared to have the highest association, followed by items of negative feelings, energy, and concentration. Conclusions: The BSRS-5 score is predictive for scores of all four domains and 26 items of the Taiwanese version of the WHOQOL-BREF for regular factory workers. © The Author(s) 2011. Source

Tsai W.-Y.,A-Life Medical | Wu J.-L.,Tri Service General Hospital | Liu C.-C.,Cathay General Hospital | Cherng C.-H.,Tri Service General Hospital | And 4 more authors.
Connective Tissue Research | Year: 2013

Subject: Hyaluronic acid (HA) is widely used to relieve the symptoms of osteoarthritis (OA). An association of reduction of glutamate content with the synovial fluid of OA rats was reported previously. Design: Anterior cruciate ligament transaction (ACLT) was performed on one knee in male Wistar rats, the other knee was assigned to sham control and HA or saline was injected intraarticularly into the ACLT knee from week 3 to week 7. Knee dialysate was collected for amino acid measurement at week 20. Morphology and histopathology of the femoral medial condyles and synovium were examined and evaluated using Mankin and synovitis scores. Results: HA injection provided better cartilage (3.38 ± 0.03 vs. 5.45 ± 0.0.02) and synovial condition (3 ± 0.02 vs. 6.03 ± 0.02) than saline controls. Moreover, HA injection reduced the concentration of glutamates in knee dialysates compared to saline controls (1.11 ± 0.14-folds and 2.21 ± 0.19-folds of the sham-operated knee, respectively). Cystine/glutamate antiporter system expression was significantly downregulated in the saline group, but not in the HA group (0.32 ± 0.08-folds and 0.71 ± 0.10-folds of the sham-operated knee, respectively). Conclusion: Early intraarticular injection of HA attenuates the progression of cartilage destruction in the ACLT knee, and the downregulation of the cystine/glutamate antiporter system was accompanied by the progression of OA. © 2013 Informa Healthcare USA, Inc. Source

Wu Y.-C.,Fooyin University | Lin L.-F.,Ping Tung Christian Hospital | Yeh C.-S.,Fooyin University | Lin Y.-L.,Fooyin University | And 5 more authors.
Fooyin Journal of Health Sciences | Year: 2010

Peptic ulcer is a common gastrointestinal disease and produces mucosa erosion. The current study assessed the ability of burdock essence to repair gastrointestinal mucosa in clinical trials. In the experimental group, two tablets of burdock essence (500 mg/tablet) were administered three times a day after meals and a placebo was administered in controls. Four weeks after drug administration, the subjects in the study underwent an assessment for the efficacy of burdock essence as health supplements before and after administration of the drug. The presence of gastric mucosal lesions was determined in all of the peptic ulcer patients using electronic endoscopy before and after taking burdock essence. A rapid urease test on tissue samples from ulcers was conducted to verify Helicobacter pylori infection. Endoscopy confirmed gastric or duodenal ulcers in 30 patients. In clinical trials of 27 patients, 20 patients took burdock essence; 17 (85%) recovered completely and three (15%) did not. Of the seven patients who took placebos, five (71%) did not completely recover and two (29%) recovered. In the experimental group, the ulcer wounds of the three patients who had taken burdock essence did not completely heal, but wounds were reduced in size by 30%, 75%, and 33%. Moreover, 10 out of 11 patients who originally were positive for H. pylori infections no longer had the pathogen by the end of the trial. These results indicate that burdock essence has an inhibitory effect on H. pylori. This study confirms that two tablets (500 mg/tablet) of burdock essence taken orally three times a day after meals can help abolish H. pylori infection and promote the therapeutic effect of conventional medication on gastric mucosal repair in gastrointestinal ulcer patients. © 2010 Fooyin University. Source

Chien J.-M.,Ping Tung Christian Hospital | Chou C.-T.,Chang Gung Institute of Technology | Pan C.-C.,Kaohsiung Veterans General Hospital | Pan C.-C.,National Sun Yat - sen University | And 11 more authors.
Human and Experimental Toxicology | Year: 2011

Effect of sertraline, an antidepressant, on cytosolic free Ca 2++ levels ([Ca 2+]i) in human cancer cells is unclear. This study examined if sertraline altered basal [Ca 2+]i levels in suspended OC2 human oral cancer by using fura-2 as a Ca 2++-sensitive fluorescent probe. At concentrations of 10-100 μM, sertraline induced a [Ca 2+]i rise in a concentration-dependent fashion. The Ca 2++ signal was reduced partly by removing extracellular Ca 2++ indicating that Ca 2++ entry and release both contributed to the [Ca 2+]i rise. Sertraline induced Mn2+ influx, leading to quench of fura-2 fluorescence suggesting Ca 2++ influx. This Ca 2++ influx was inhibited by suppression of phospholipase A2, inhibition of store-operated Ca 2++ channels or by modulation of protein kinase C activity. In Ca 2++-free medium, pretreatment with the endoplasmic reticulum Ca 2++ pump inhibitor thapsigargin or 2,5-di-(t-butyl)-1,4- hydroquinone (BHQ) nearly abolished sertraline-induced Ca 2++ release. Conversely, pretreatment with sertraline greatly reduced the inhibitor-induced [Ca 2+]i rise, suggesting that sertraline released Ca 2++ from the endoplasmic reticulum. Inhibition of phospholipase C did not change sertraline-induced [Ca 2+]i rise. Together, in human oral cancer cells, sertraline induced [Ca 2+]i rises by causing phospholipase C-independent Ca 2++ release from the endoplasmic reticulum and Ca 2++ influx via store-operated Ca 2++ channels. © SAGE Publications 2011. Source

Chien J.-M.,Ping Tung Christian Hospital | Chou C.-T.,Chang Gung University | Lu Y.-C.,Kaohsiung Veterans General Hospital | Lu T.,Kaohsiung Veterans General Hospital | And 7 more authors.
Environmental Toxicology and Pharmacology | Year: 2013

The environmental pollutant bisphenol A dimethacylate (BAD) has been used as a dental composite. The effect of BAD on cytosolic Ca2+ concentrations ([Ca2+]i) and viability in OC2 human oral cancer cells was explored. The Ca2+-sensitive fluorescent dye fura-2 was applied to measure [Ca2+]i. BAD induced [Ca2+]i rises in a concentration-dependent manner. The response was reduced by removing extracellular Ca2+. BAD-evoked Ca2+ entry was suppressed by nifedipine, econazole, and SK&F96365. In Ca2+-free medium, incubation with the endoplasmic reticulum Ca2+ pump inhibitor thapsigargin abolished BAD-induced [Ca2+]i rise. Inhibition of phospholipase C with U73122 did not alter BAD-induced [Ca2+]i rise. At 10-30μM, BAD inhibited cell viability, which was not reversed by chelating cytosolic Ca2+. BAD (20-30μM) also induced apoptosis. Collectively, in OC2 cells, BAD induced a [Ca2+]i rise by evoking phospholipase C-independent Ca2+ release from the endoplasmic reticulum and Ca2+ entry via store-operated Ca2+ channels. BAD also caused apoptosis. © 2012 Elsevier B.V. Source

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