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Puducherry, India

Dasgupta A.,All India Institute of Hygiene and Public Health | Parthasarathi R.,All India Institute of Hygiene and Public Health | Ram Prabhakar V.,All India Institute of Hygiene and Public Health | Biswas R.,All India Institute of Hygiene and Public Health | Geethanjali A.,PIMS
Indian Journal of Community Health

Background: Under-nutrition continues to be a major public health problem in India despite years of incessant preventive measures. Composite index of anthropometric failure (CIAF) provides the burden of under-nutrition as a single measure and helps in detection of children with multiple anthropometric failures. Research with multivariate modelling for various factors associated with CIAF is limited especially in rural West Bengal. Methods: This cross-sectional community based study was done in Singur block of West Bengal to determine the prevalence of under-nutrition among the under-five children and to find out the determinants of under-nutrition assessed by CIAF using multivariate analysis. WHO Z-score system and the composite index of anthropometric failure (CIAF) were used to estimate the magnitude of under-nutrition. Results: Out of 113 children, 37 (32.7%) were suffering from under-nutrition according to CIAF. Both underweight and wasting was present in 17.7% while stunting was prevalent in 15%. Multivariate logistic regression model showed that high birth order, low birth weight, lesser duration of breast-feeding, and low education level of mother were significantly associated with under-nutrition assessed by CIAF after adjusting for other variables. Conclusion: CIAF gives a better estimate of under-nutrition than the currently used weight-for-age Z score, hence we recommend the inclusion of height measurement in growth monitoring activities for calculating CIAF. The study also reinforces the importance of appropriate maternal care, proper infant and child feeding practices and family planning services in prevention of under-nutrition. Source

Singla R.K.,GMC Amritsar | Kaur N.,PIMS
Journal of Clinical and Diagnostic Research

Introduction: Neurovascular variations in the upper limb are common and they are well documented. An accurate knowledge of the normal and the variant anatomy of the median nerve and the median artery are important for clinical procedures and for vascular surgeries. The persistant median artery is one such anomaly which was seen in 6.6% (4) of the 60 upper limbs which were dissected in the present study, it being bilateral in one cadaver. Material and Methods: The present study was conducted on 60 upper limbs of 30 cadavers at the Government Medical College, Amritsar, India. The whole course of the median nerve and the persistant median artery was exposed. Results: In all the 4 variant limbs, the persistent median artery originated from the anterior interrosseous artery and terminated in the incomplete mediano- ulnar type of the superficial palmar arch. In three upper limbs, the persistant median artery simply accompanied the median nerve upto the palm. But in the left upper limb of the cadaver with the bilateral variation, the artery penetrated and divided the nerve into two halves which joined to form a neural loop around the artery. Thereafter, the nerve and the artery followed the same course upto the palm. Such a penetration of the median nerve by the persistent median artery is extremely rare. Further, its ontogeny and clinical implications have been discussed in detail. Source

Syed K.N.,PIMS
Journal of the Pakistan Medical Association

Tuberous sclerosis or Tuberous Sclerosis Complex (TSC) is a genetic disorder characterized by the growth of numerous benign tumours in many parts of the body caused by mutations on either of two genes, TSC1 and TSC2. The case of a 31 year old female who fulfilled 8 major criteria of Tuberous Sclerosis Complex is reported. Multiple research work projects are being carried out on this disease, unfolding the realities regarding its etiology as well as treatment. TSC patients, besides receiving symptomatic treatment should also be offered special schooling and regular follow up by expert physician. Source

Mooez M.,COMSATS Institute of Information Technology | Malik F.A.,COMSATS Institute of Information Technology | Kayani M.A.,COMSATS Institute of Information Technology | Ashid A.,PIMS | And 2 more authors.
Asian Pacific Journal of Cancer Prevention

Background: Metastasis suppressor genes are involved in the inhibition of a cancer cell's ability to metastasize. Down expression of such genes may contribute to pathogenesis of breast cancer. The aim of current study was firstly to evaluate expression of two examples, KAI1 and KISS1, and then to determine relationships with stages of breast cancer in a Pakistani population. Methodology: Fresh biopsy tissues were collected from different hospitals and oncology research institutes. The semi quantitative reverse transcriptase polymerase chain reaction was used to investigate KAI1 and KISS1 expression in 25 breast tumor tissues and 25 normal tissues. Statistical analysis was performed to explore its association with breast cancer risk. Results: The present study revealed that KAI1 and KISS1 mRNA expression was markedly reduced in tissues of breast cancer compared to adjacent normal tissue. In present study a splice variant of KAI1 during a screen for its expression analysis was also observed. This splice variant has not been reported previously. Conclusions: Metastasis suppressor genes demonstrate reduced expression in breast cancers in Pakistan. Source

Saaiq M.,PIMS | Zaman K.U.,PIMS
Journal of the College of Physicians and Surgeons Pakistan

Objective: To determine the residents' rating of the quality of their residency training by measuring their level of satisfaction with the various educational attributes of their training. Study Design: Cross-sectional survey. Place and Duration of Study: Department of Medical Education (DME), Pakistan Institute of Medical Sciences (PIMS), Islamabad, from September to November 2008. Methodology: Residents who had been pursuing residency training for over a period of one year were included. A comprehensive questionnaire consisting of 14 questions was employed which covered fundamental attributes of the quality of postgraduate training. A five point response scale was used to rate responses to questions. Results for each of the measures of all the included residents were added up, and then an average was calculated and scaled to a score out of 100 to form the Index Score. In this way the residents' level of agreement or disagreement with the questioned statement was measured from 'Strongly disagree' (0%) to 'Strongly agree' (100%). Results: Out of a total of 150 residents contacted, 109 answered the questionnaire. The response rate was thus 73%. Residents variably rated the various educational attributes of their residency training. Relatively favourably rated areas included regular conduct of case/ topic discussions (75.96%), consultant's supervision during interventional procedures (70.27%) and regularly holding journal clubs (69.54%). The less favourably rated areas included constructive feedback by supervisor (54.49%), consultant as role model (54.49%) and faculty as the source of learning (50.82%). Overall, the Index Score was 60.55%. Conclusion: Significant room exists for improvement in the quality of residency training as indicated by the less than desirable ratings of the various educational attributes of the residency programme. Faculty members who constitute the cornerstone of educational process are pivotal to effect the desired improvements. Source

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