PILOT Corporation

Kawasaki, Japan

PILOT Corporation

Kawasaki, Japan

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Kuboki Y.,Hokkaido University | Kuboki Y.,Xinxiang Medical University | Yagami K.,Matsumoto Dental University | Iku S.,Xinxiang Medical University | And 7 more authors.
Nano Biomedicine | Year: 2010

Previously we have shown that honeycomb-shaped hydroxyapatite ceramics (HC-HAP) of different tunnel sizes control the formation bone and cartilage when implanted into rat skin with bone morpho- genetic protein (BMP). The HC-HAP of larger tunnel size (300-400μm) induced bone directly, while the smaller size (90-110μm) induced endochondral ossification. Concerning this interesting tendency of bone-cartilage biphasic phenomena that was observed in hydroxyapatite ceramics, we wanted to know whether the same phenomena occur in β-tri-calcium phosphate (β-TCP) ceramics. We prepared honey-comb-shaped β-TCP ceramics (HC-β-TCP) of disk type with three-different tunnel sizes, 300, 75 and 50μm, having tunnel numbers of 37, 568 and 907 per ceramic, respectively within a cross-section of 3.1mm disk diameter. When implanted into rats subcutaneously with BMP-2, HC-β-TCP of three different tunnel diameters all induced active bone tissue formation, with the highest ALP value in HC-β-TCP with tunnel diameter of 75μm. Interestingly, an appreciable amount of cartilage formation was observed only in the early stage of implantation of the HC-β-TCP with a tunnel size of 50μlm, but not with ones of 75μm, and as expected, of 300μm. The results were essentially similar to ones obtained using hydroxyapatite with tunnel sizes of 90-110μm, in which clear endochondral processes were observed. We hypothesized that the slightly different tendency may be attributed mainly to the chemical properties of the two ceramics: hydroxyapatite is non-biodegradable, whileβ-TCP is a biodegradable ceramic.


Takabatake K.,Okayama University of Science | Yamachika E.,Okayama University of Science | Tsujigiwa H.,Okayama University of Science | Takeda Y.,Sumitomo Besshi Hospital | And 4 more authors.
Journal of Biomedical Materials Research - Part A | Year: 2014

In recent years, artificial biological materials have been commonly used for the treatment of bone tissue defects caused by trauma, tumors, or surgical stress. Although tricalcium phosphate (TCP) is a promising absorbent bone tissue reconstruction biomaterial, it has been reported that its biocompatibility and osteoconductivity depend on its preparation method and sintering temperature. In addition, although it is thought that the microenvironment produced by the extracellular matrix plays an important role in cell growth and differentiation, there have been few studies on how the geometric structure of artificial biological materials affects cells. In the present study, a new honeycomb TCP scaffold containing through-holes with diameters of 300 μm has been developed. The influence of the sintering temperature on the crystal structure and material properties of the honeycomb TCP scaffold was investigated using scanning electron microscopy and X-ray diffraction. Its biocompatibility and osteoconductivity were also evaluated by implantation into experimental animals. It was found that a β-TCP scaffold sintered at 1200°C exhibited high biocompatibility and osteoconductivity, and when it was loaded with BMP-2, it exhibited both osteoconductivity and osteoinductivity, promoting rapid bone formation in both ectopic and orthotopic areas. It is thus a highly promising bone reconstruction material that is expected to find clinical applications. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2952-2960, 2014. © 2013 Wiley Periodicals, Inc.


Saito E.,Hokkaido University | Saito A.,Hokkaido University | Kuboki Y.,Hokkaido University | Kimura M.,PILOT Corporation | And 3 more authors.
Dental Materials Journal | Year: 2012

The aim of this study was to investigate the effect of the pore characteristics of β-tricalcium phosphate (β-TCP) on periodontal healing in class III furcation defects in dogs. Two types of β-TCP were prepared for grafting; 1) a tunnel pipe structure with an inner diameter of 300 μm, and 2) continuous pore structure with interconnected macropores. The furcations of thirty mandibular premolar teeth were implanted with each type of β-TCP or were left untreated as control. The dogs were sacrificed 8 weeks post-surgery, and healing was evaluated histologically. Downgrowth of junctional epithelium in the tunnel structure group was significantly less than that in the other two groups (p<0.01). There was significantly more new bone formation and new cementum formation in the tunnel structure group than that in the other two groups (p<0.01). These findings suggested that β-TCP with a tunnel pipe structure promotes periodontal healing in class III furcation defects.


Saito A.,Hokkaido University | Saito E.,Hokkaido University | Kuboki Y.,Hokkaido University | Kimura M.,PILOT Corporation | And 6 more authors.
Dental Materials Journal | Year: 2013

The aim of this study was to investigate the effect of tunnel structured β-tricalcium phosphate (β-TCP) on the regenerative potential of basic fibroblast growth factor-2 (bFGF-2) in class III furcation defects in dogs. The furcations of 30 mandibular premolar teeth received: 1) 0.3% bFGF-2 solution in conjunction with β-TCP; 2) 0.3% bFGF-2 solution; and 3) no implant material (Control group). The dogs were sacrificed 8 weeks post-surgery, and healing was evaluated histologically. New bone formation was significantly greater in the bFGF-2/β-TCP group compared to the bFGF-2 solution and Control groups (p<0.01). New cementum formation in the bFGF-2/β-TCP and bFGF-2 solution groups was significantly greater than that in the Control group (p<0.01). These findings suggested that bFGF-2 alone enhances connective tissue attachment in a manner similar to the combination of bFGF-2 and β-TCP. Furthermore, this combination enhances bone formation up to the fornix in class III furcation defects.


Soutome T.,PILOT Corporation
Nihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C | Year: 2012

The objective of this investigation is an invention of theory and technics on surface roughness≒O, roundness≒O, and cylindricity≒0 boring as small diameter and long length. In this paper it is analyzed that high precision boring can be achieved with combining the insensitive vibration cutting mechanism, microgroove selfcontrol mechanism on (40Hz+ 30kHz) superposition superfinishing, the main spindle system with air bearing and the carriage system with the pneumatic floating system. These mechanisms which can reduce cutting resistance are especially effective for precision boring, because in this case the rigidity of the tool shank is very low. The concrete methods are as follows: In the first process, the work which is chucked on the main spindle with air bearing is machined as acting a continuously and systematically pulsating cutting force by the ultrasonic vibration cutting mechanism. In the following process, the work is finished by the newly developed (40Hz+30kHz) superposition superfinishing device. After all, to actualize machining surface roughness of 0.1∼0.5 μ mRz, roundness of 0.1∼0.5 μ m, cylindricity of 0∼0.5 μ m/60mm, is succeeded in work material of duralmin, brass, carbon steel, stainless steel, hardend steel (HRC39, HRC52). It is found that the high precision boring can be realized by means of this new machining process and its lathe. © 2012 The Japan Society of Mechanical Engineers.


Soutome T.,PILOT Corporation
Nihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C | Year: 2010

In this investigation a high efficient mirror machining process with providing above 20 kHz ultrasonic vibration and 20-50 Hz low frequent vibration to fine abrasive stone, has been created and named "Superposition superfinishing (SSF process) ". This machining process consists of the first cutting process (SVC process : superposition vibration cutting) and the second mirror machining process (SF process: superfinishing). To finally obtain a high efficient and high precision mirror surface with smoothness, more fine uneven surface roughness on first cutting process is desired, because the mirror finishing time on second process can be reduced. Until now, in several experiments it was practically observed that surface roughness by superposition vibration cutting is smaller than that by superfinishing without stone loading. In this report, some experiments have been examined to confirm this inproving effect in detail. Experimental conditions are as follows: Rotational frequency of work: 60-950min-1. Work diameter (material) : ø35mm (SKS3, HRC47), Frequency F and Amplitude A of Low frequent vibration : 0-25 Hz, 0-1 mm, Frequency f and Amplitude a of ultrasonic vibration: 0-46 kHz, 0-7.5μm, Stone Pressure P: 24.5-196 kPa, Stone: WA (600-3000) RH (20-80) V, Machining fluid : Light oil. In this paper, it is confirmed with analyzing and experiments that surface roughness by SVC process can be improved in comparison with SF process without stone loading.


Soutome T.,PILOT CORPORATION
Nihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C | Year: 2010

The objective of this invesitigation is to clarify a new and high efficient mirror machining process with using ultrasonic and low frequent vibrations, that has been named "superposition superfinishing (SSF process)". In the first report, it was confirmed that a stock removal rate of superposition vibration cutting as cutting process on this SSF process can be higher than that of low frequent superfinishing, and that a high efficient mirror machining can be practically achieved. In the second report, by analysis and consideration on superposition cutting track, it was found that cutting length of this superposition vibration cutting strongly influence on a stock removal amount. In this report, as one reason of obtaining a high stock removal rate, we have adopt equivalent grade characteristics of ultrasonically vibrated abrasive stone. It has be shown that the grade of abrasive stone decreases according as amplitude incleases. On the result of some experiments, it is found that this phenomenon can be controlled by an amplitude value of ultrasonic vibration, and that a rate of abrasive stone ware per one meter of superposition superfinishing is lower than that of low frequent superfinishing in the case of large maximum cross angle.


Patent
Pilot Ltd | Date: 2012-05-16

There is discussed an orientation sensor having a first mounting means for mounting the orientation sensor to an object, a second mounting means mounting a member to the first mounting means; and two or more accelerometers provided on said member. The second mounting means is an anti-vibration mount operable to attenuate vibrational movement travelling from the object to the member. In this way, the two accelerometers provide readings which can be used to determine the orientation of the object. One application for the orientation sensor is to determine the orientation of a motorcycle as it corners.


Patent
Pilot Corporation | Date: 2015-05-20

Provided is a thermochromic retractable ballpoint pen including a friction body at a rear end of a barrel for easy thermochromicity only in a desired area. A retractable ballpoint pen is characterized by that the pen includes a friction body, at a rear end of the barrel, used for friction of handwriting in the thermochromic ink, enabling thermochromism of the handwriting in the thermochromic ink with frictional heat produced at that time, and having rubber-like elasticity, a maximum outer diameter of the rear end of the barrel is from 1.0 times to 1.5 times a maximum outer diameter of the friction body, a maximum width in a circumferential direction of the operating portion is less than the maximum outer diameter of the friction body, and an angle of a tangent to both the friction body and the operating portion from a writing surface is 60 degrees or more when the friction body is downward and an axial line of the barrel is in a vertical state relative to the writing surface.

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