PIC Germany

Schleswig, Germany

PIC Germany

Schleswig, Germany
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Duthie C.-A.,Sustainable Livestock Systems Group | Simm G.,Sustainable Livestock Systems Group | Doeschl-Wilson A.,Sustainable Livestock Systems Group | Kalm E.,University of Kiel | And 2 more authors.
Meat Science | Year: 2011

The aim of the research was to gain a better understanding of the genomic regulation of meat quality by investigating individual and epistatic QTL in a three-generation full-sib population (Pietrain × crossbred dam line). In total, 386 animals were genotyped for 96 markers. Analysed traits included pH, reflectance value, conductivity, and meat colour. Thirteen significant individual QTL were identified. The most significant QTL were detected on SSC1 and SSC9 for pH, on SSC4 for meat colour, and on SSC8 for conductivity, accounting for 3.4% to 4.7% of the phenotypic variance. Nine significant epistatic QTL pairs were detected accounting for between 5.7% and 10.9% of the phenotypic variance. Epistatic QTL pairs showing the largest effects were for reflectance value between two locations of SSC4, and for pH between SSC10 and SSC13, explaining 9.5% and 10.9% of the phenotypic variance, respectively. This study indicates that meat quality traits are influenced by numerous QTL as well as a complex network of interactions. © 2010 The American Meat Science Association.

Duthie C.,Sustainable Livestock Systems Group | Simm G.,Sustainable Livestock Systems Group | Doeschl-Wilson A.,Sustainable Livestock Systems Group | Kalm E.,University of Kiel | And 2 more authors.
Journal of Animal Science | Year: 2010

The present study focused on the identification of epistatic QTL pairs for body composition traits (carcass cut, lean tissue, and fat tissue weights) measured at slaughter weight (140 kg of BW) in a 3-generation full-sib population developed by crossing Pietrain sires with a crossbred dam line. Depending on the trait, phenotypic observations were available for 306 to 315 F2 animals. For the QTL analysis, 386 animals were genotyped for 88 molecular markers covering chromosomes SSC1, SSC2, SSC4, SSC6, SSC7, SSC8, SSC9, SSC10, SSC13, and SSC14. In total, 23 significant epistatic QTL pairs were identified, with the additive x additive genetic interaction being the most prevalent. Epistatic QTL were identified across all chromosomes except for SSC13, and epistatic QTL pairs accounted for between 5.8 and 10.2% of the phenotypic variance. Seven epistatic QTL pairs were between QTL that resided on the same chromosome, and 16 were between QTL that resided on different chromosomes. Sus scrofa chromosome 1, SSC2, SSC4, SSC6, SSC8, and SSC9 harbored the greatest number of epistatic QTL. The epistatic QTL pair with the greatest effect was for the entire loin weight between 2 locations on SSC7, explaining 10.2% of the phenotypic variance. Epistatic associations were identified between regions of the genome that contain the IGF-2 or melanocortin-4 receptor genes, with QTL residing in other genomic locations. Quantitative trait loci in the region of the melanocortin-4 receptor gene and on SSC7 showed significant positive dominance effects for entire belly weight, which were offset by negative dominance x dominance interactions between these QTL. In contrast, the QTL in the region of the IGF-2 gene showed significant negative dominance effects for entire ham weight, which were largely overcompensated for by positive additive x dominance genetic effects with a QTL on SSC9. The study shows that epistasis is of great importance for the genomic regulation of body composition in pigs and contributes substantially to the variation in complex traits. © 2010 American Society of Animal Science.

Preissler R.,Martin Luther University of Halle Wittenberg | Tetens J.,University of Kiel | Reiners K.,PIC Germany | Looft H.,PIC Germany | Kemper N.,Martin Luther University of Halle Wittenberg
Animal Genetics | Year: 2013

Postpartum dysgalactia syndrome (PDS) in sows is an important disease after parturition with a relevant economic impact, affecting the health and welfare of both sows and piglets. The genetic background of this disease has been discussed and its heritability estimated, but further genetic analyses are lacking in detail. The aim of the current study was to detect loci affecting the susceptibility to PDS through a genome-wide association approach. The study was designed as a family-based association study with matched sampling of affected sows and healthy half- or full-sib control sows on six farms. For the study, 597 sows (322 affected vs. 275 healthy control sows) were genotyped on 62 163 single nucleotide polymorphisms (SNPs) using the Illumina PorcineSNP60 BeadChip. After quality control, 585 sows (314 affected vs. 271 healthy control sows) and 49 740 SNPs remained for further analysis. Statistics were performed mainly with the r package genabel and included a principal component analysis. A statistically significant genome-wide associated SNP was identified on porcine chromosome (SSC) 17. Further promising results with moderate significance were detected on SSC 13 and on an unplaced scaffold with an older annotation on SSC 15. The PRICKLE2 and NRP2 genes were identified as candidate genes near associated SNPs. Several quantitative trait loci (QTL) have been previously described in these genomic regions, including QTL for mammary gland condition, as teat number and non-functional nipples QTL, as well as QTL for body temperature and gestation length. © 2013 The Authors, Animal Genetics © 2013 Stichting International Foundation for Animal Genetics.

Preissler R.,Martin Luther University of Halle Wittenberg | Preissler R.,University of Kiel | Hinrichs D.,University of Kiel | Reiners K.,PIC Germany | And 2 more authors.
Journal of Animal Breeding and Genetics | Year: 2012

The postpartum dysgalactia syndrome (PDS) represents one of the most important diseases after parturition in sows. The genetic background of the disease has been investigated some time ago and heritability estimates around 0.10 have been obtained. To compute current estimates, a dataset of 1680 sampled sows and their 2001 clinically examined litters was used for variance components estimation with a threshold liability model. Affected sows were defined through clinical examination 12-48h after parturition. Posterior mean of additive genetic variance was 0.10 and estimated heritability for PDS averaged 0.0879 with a 95% confidence interval of 0.0876 and 0.0881. The results are in agreement with those of other studies and emphasize the importance of considering the genetic predisposition for susceptibility to PDS as well as of additional factors including hygiene and management conditions. © 2011 Blackwell Verlag GmbH.

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