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Sammichele di Bari, Italy

Abadi A.T.B.,Tarbiat Modares University | Ierardi E.,Piazza Giulio Cesare | Lee Y.Y.,Universiti Sains Malaysia
Malaysian Journal of Medical Sciences | Year: 2015

The existence of any infectious agent in a highly acidic human stomach is contentious, but the chance finding of Helicobacter pylori is by no means an accident. Once H. pylori colonises the gastric mucosa, it can persist for a lifetime, and it is intriguing why our immune system is able to tolerate its existence. Some conditions favour the persistence of H. pylori in the stomach, but other conditions oppose the colonisation of this bacterium. Populations with high and extremely low prevalence of H. pylori provide useful insights on the clinical outcomes that are associated with this type of infection. Adverse clinical outcomes including peptic ulcer disease and gastric cancer depend on a delicate balance between a harmless inflammation and a more severe kind of inflammation. Is the only good H. pylori really a dead H. pylori? The jury is still out. © Penerbit Universiti Sains Malaysia, 2015.

Inchingolo F.,University of Bari | Inchingolo F.,University of Milan | Tatullo M.,Calabrodental | Tatullo M.,University of Milan | And 5 more authors.
International Journal of Surgery Case Reports | Year: 2011

Introduction: Portable firearms have a relevant medico-legal interest, being a major cause of injury. Bullet entry wounds generally have a particular appearance, including contusion, skin introflection, and simple or excoriated ecchymosis. The skin wound is typically a hole with frayed margins, whose diameter is smaller than that of the bullet. Presentation of case: We report the case of a 19-year-old man with ballistic trauma. Examination of the patient's lesions indicated that the bullet had entered from the left mandibular parasymphysis, creating a small hole without the typical bullet wipe and blackening. Subsequently, the bullet seemed to have fractured the left chin region immediately below the lower alveolar process, and it finally stopped in the submandibular area in the suprahyoid region of the neck. Discussion: This case is peculiar because the distinctive features of a firearm injury were absent; the lack of bleeding and edema made the case difficult to interpret without additional diagnostic investigations. Conclusion: Ballistic trauma can manifest in different ways; therefore, internal trauma should be suspected even in the absence of clear external signs. This case report shows how an unusual bullet entry hole can mask quite serious injuries. © 2011 Surgical Associates Ltd.

Nettis E.,University of Bari | D'Erasmo M.,University of Bari | Di Leo E.,University of Bari | Calogiuri G.F.,Piazza Giulio Cesare | And 3 more authors.
Italian Journal of Allergy and Clinical Immunology | Year: 2010

The first-line treatment for atopic dermatitis is the correction of disorders of the skin barrier through the regular use of moisturizers, emollients, and products against itch. Identification and elimination of trigger factors have also therapeutic importance. For cleansing the atopic skin use of detergents as fragrance-free formulations, non-irritating and hypoallergenic are recommended. Bathrooms oiled may be useful in the acute phase, while antibacterial cleaners are indicated in patients with frequent folliculitis or recurring skin infections. Step by step management strategies, which are based on the severity of the manifestations, provide the progressive addition of topical and systemic pharmacological agents. Standard topical therapy includes topical corticosteroids and topical calcineurin inhibitors. Topical corticosteroids are still the major drugs needed to control the inflammatory component and the exacerbation of atopic eczema. Knowledge of power, risks and benefits of topical steroids is of key importance to avoid the occurrence of side effects linked to their improper use. Tacrolimus, pimecrolimus, and topical calcineurin inhibitors have immune-modulating and anti-inflammatory activity, and have been approved for the treatment of atopic eczema in the case of failure of other topical treatments or when other treatments are not recommended. According to international guidelines, severe refractory dermatitis require the use of systemic treatment with corticosteroids, cyclosporin A, and azathioprine. Traditional therapy applied for the treatment of atopic dermatitis is not always effective and may have significant side effects. The biologic drugs represent a new therapeutic approach, although their efficacy and tolerability must be validated by controlled studies.

Amico F.,University College Dublin | Ambrosini E.,University of Padua | Mento G.,University of Padua | Power D.,Materials Misericordiae University Hospital | And 3 more authors.
International Journal of Psychophysiology | Year: 2015

We explored a novel method to electrophysiologically measure visuo-spatial recognition memory using a modified version of the Virtual Tray of Objects Task (VTOT). Event-related potentials (ERP) were recorded from 18 healthy volunteers during performance in the VTOT. Participants were required to detect random repetitions of three-dimensional visual stimuli (OLD) and to refrain from responding to non-repeated stimuli (NEW). Differences in ERP between the NEW and OLD conditions were tested for statistical significance using assumption-free non-parametric analyses. Further, a correlation between ERP and behavioral measures was sought. Significant OLD-NEW effects were found for four ERP components showing distinct spatio-temporal characteristics: a posterior positive component appearing at 100 ms (P100), a left-lateralized negative component peaking at ≈ 250 ms (N250), a frontal negative component at ≈ 300-450 ms (FN400), and a right late frontal negativity (rLFN) at ≈ 500-720. ms. Moreover, individual differences in the OLD-NEW effect computed for the rLFN positively correlated with repeated stimulus recognition efficiency. However, there were no late left parietal P600 old/new effects. These findings suggest that the P100 component might reflect early visual perception processes taking place during performance in the task, whereas the N250 and FN400 components could be linked to stimulus-dependent access to visual memory representations and familiarity-related processes, respectively. In contrast, we propose that the rLFN component could be associated with higher-level cognitive functions, such as attention and monitoring processes. Altogether, our results suggest that the ERP version of the VTOT could play a role in the electrophysiological assessment of visuo-spatial memory and related sub-processes. © 2015 Elsevier B.V.

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