Phytoquest Ltd

Aberystwyth, United Kingdom

Phytoquest Ltd

Aberystwyth, United Kingdom
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Jenkinson S.F.,University of Oxford | Fleet G.W.J.,University of Oxford | Nash R.J.,Phytoquest Ltd | Koike Y.,University of Toyama | And 5 more authors.
Organic Letters | Year: 2011

The enantiomers of tagatose are converted to l-DGJ [a noncompetitive inhibitor of human lysosome α-galactosidase A (α-Gal A), K i 38.5 μM] and DGJ [a competitive inhibitor of α-Gal A, K i 15.1 nM] in 66% yield. l-DGJ and DGJ provide the first examples of pharmacological chaperones that (a) are enantiomeric iminosugars and (b) have synergistic activity with implications for the treatment of lysosomal storage disorders and other protein deficiencies. © 2011 American Chemical Society.


Au C.W.G.,University of Wollongong | Nash R.J.,Phytoquest Ltd | Pyne S.G.,University of Wollongong
Chemical Communications | Year: 2010

The synthesis of hyacinthacines B3 and B7 has confirmed the structure of the former alkaloid and shown that the structure of the latter is incorrect. © 2010 The Royal Society of Chemistry.


Ritthiwigrom T.,University of Wollongong | Nash R.J.,Phytoquest Ltd | Pyne S.G.,University of Wollongong
Tetrahedron | Year: 2010

The synthesis of the natural product 3-epi-casuarine and two tricyclic ether bridged analogues, plus 7-deoxy-3,6-diepi-casuarine, 7-epi-australine, 1-epi-castanospermine and 1,6-diepi-castanospermine is described. The glycosidase inhibitory activities of these compounds, along with that of uniflorine A and other polyhydroxylated pyrrolizidines and indolizidines that we have published before, are reported. © 2010 Elsevier Ltd. All rights reserved.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Collaborative Research & Development | Award Amount: 700.66K | Year: 2015

Liver fluke in cattle and sheep represents an increasing economic problem, particularly because of developing resistance to available drugs, as well as representing a serious animal welfare issue. This project will develop a nature based alternative treatment by using a bulk chemical that can be isolated in large quantities from a common non-food plant which is currently little used in the UK and often controlled by burning. The plant material, which itself is know to be actve against fluke, will be converted into a single chemical entity by simple processes and then modified to optimise its activity. This will be determined using a highly specialised approach measuring in vitro many individual effects on the fluke, and during small in vivo studies. The consortium will develop and cost a complete product dossier, including material supply, product formulation, efficacy and delivery systems, a route to market,and an analysis of the potential benefits in controlling disease; it is expected that this project portfolio will either lead to a consortium partner moving directly to the process of full product registration , or to the consortium licencing the outputs so that such a process could begin.


Patent
Phytoquest Ltd | Date: 2016-01-27

Processes for the production of a composition comprising material derived from seeds of plants of the genus Oryza, the process comprise the steps of: (a) providing material derived from seeds of the genus Oryza; and (b) determining the presence or absence and/or measuring the amount of at least one iminosugar in the material of step (a). Also described is the use of material derived from seeds of plants of the genus Oryza, which material comprises at least one iminosugar, as a food or feed supplement for lowering the glycaemic index (GI) value of said food or feed.


Patent
Phytoquest Ltd | Date: 2016-03-31

Compositions comprising isolated ido-BR1 are described for use in therapy or prophylaxis, including the treatment of inflammatory diseases (for example as anti-inflammatory drugs) and to reduce inflammation. Also described are methods for monitoring the quality of a Cucurbitaceae extract, to processes for producing a Cucurbitaceae extract as well as to Cucurbitaceae extracts obtainable by such processes.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Collaborative Research & Development | Award Amount: 550.82K | Year: 2012

Protozoal organisms in the rumen of animals such as cattle and sheep reduce their ability to utilise protein efficiently and increase their production of methane, an important greenhouse gas which may lead to increased global warming. Saponins from ivy have been shown by the team to reduce protozoal growth but the effect wears off as the protozoa remove sugars from the saponins and inactivate them. Glycosidase inhibitors from some food waste materials can slow this inactivation. The team will find the best combinations of saponins and glycosidase inhibitors for commercial production. Other uses are also also being considered by the project partners.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Innovation Voucher | Award Amount: 5.00K | Year: 2012

PhytoQuest Limited has novel anti-inflammatory agents from cucumbers that it will evaluate for animal uses using the TSB innovation voucher. Initial tests will be on bovine uterine tissues looking for possible therapeutic effects on endometriosis. Tests on horses for relieving Sweet Itch and equine endometriosis models will follow this initial research.


Patent
Phytoquest Ltd | Date: 2014-04-11

Compositions comprising isolated ido-BR1 are described for use in therapy or prophylaxis, including the treatment of inflammatory diseases (for example as anti-inflammatory drugs) and to reduce inflammation. Also described are methods for monitoring the quality of a Cucurbitaceae extract, to processes for producing a Cucurbitaceae extract as well as to Cucurbitaceae extracts obtainable by such processes.


Patent
Phytoquest Ltd | Date: 2013-06-25

Disclosed are processes for the production of composition comprising one or more fructose amino acids, said process comprising the steps of: (a) providing plant material derived from a botanical source selected from plants of the families Solanaceae, Compositae, (Asteraceae), Guttiferae, Umbelliferae, Papaveraceae, Vitidaceae or Acanthaceae; (b) extracting one or more fructose amino acid(s) from said plant material; and optionally (c) detecting the presence and/or measuring the amount of said fructose amino acid(s) in the extract of step (b).

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