Lenke J.,Phyton Biotech GmbH |
Erdmann H.,Flensburg University of Applied Sciences
BioSpektrum | Year: 2014
An important issue in food industries is the detection of microbial contaminants. Flow cytometry not only allows the rapid detection of individual cells but at the same time the quantification and determination of their viability. The concept of flow cytometric analysis has been realized by a miniaturized integrated lab-on-a-chip setup. A microfluidic system using hydrodynamic focusing was developed on a chip. © 2014 Springer-Verlag Berlin Heidelberg. Literatur:.
News Article | November 7, 2016
This report studies Paclitaxel in Global market, especially in North America, Europe, China, Japan, Southeast Asia and India, focuses on top manufacturers in global market, with capacity, production, price, revenue and market share for each manufacturer, covering Phyton Biotech ScinoPharm Novasep Samyang Polymed TAPI (Teva) Fresenius-kabi Southpharma Haiyao Huiang Biopharma Yunnan Hande Hainan Yew Pharm View Full Report With Complete TOC, List Of Figure and Table: http://globalqyresearch.com/global-paclitaxel-market-research-report-2016 Market Segment by Regions, this report splits Global into several key Regions, with production, consumption, revenue, market share and growth rate of Paclitaxel in these regions, from 2011 to 2021 (forecast), like North America Europe China Japan Southeast Asia India Split by product type, with production, revenue, price, market share and growth rate of each type, can be divided into Type I Type II Type III Split by application, this report focuses on consumption, market share and growth rate of Paclitaxel in each application, can be divided into Application 1 Application 2 Application 3 Global Paclitaxel Market Research Report 2016 1 Paclitaxel Market Overview 1.1 Product Overview and Scope of Paclitaxel 1.2 Paclitaxel Segment by Type 1.2.1 Global Production Market Share of Paclitaxel by Type in 2015 1.2.2 Type I 1.2.3 Type II 1.2.4 Type III 1.3 Paclitaxel Segment by Application 1.3.1 Paclitaxel Consumption Market Share by Application in 2015 1.3.2 Application 1 1.3.3 Application 2 1.3.4 Application 3 1.4 Paclitaxel Market by Region 1.4.1 North America Status and Prospect (2011-2021) 1.4.2 Europe Status and Prospect (2011-2021) 1.4.3 China Status and Prospect (2011-2021) 1.4.4 Japan Status and Prospect (2011-2021) 1.4.5 Southeast Asia Status and Prospect (2011-2021) 1.4.6 India Status and Prospect (2011-2021) 1.5 Global Market Size (Value) of Paclitaxel (2011-2021) 7 Global Paclitaxel Manufacturers Profiles/Analysis 7.1 Phyton Biotech 7.1.1 Company Basic Information, Manufacturing Base and Its Competitors 7.1.2 Paclitaxel Product Type, Application and Specification 18.104.22.168 Type I 22.214.171.124 Type II 7.1.3 Phyton Biotech Paclitaxel Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016) 7.1.4 Main Business/Business Overview 7.2 ScinoPharm 7.2.1 Company Basic Information, Manufacturing Base and Its Competitors 7.2.2 Paclitaxel Product Type, Application and Specification 126.96.36.199 Type I 188.8.131.52 Type II 7.2.3 ScinoPharm Paclitaxel Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016) 7.2.4 Main Business/Business Overview 7.3 Novasep 7.3.1 Company Basic Information, Manufacturing Base and Its Competitors 7.3.2 Paclitaxel Product Type, Application and Specification 184.108.40.206 Type I 220.127.116.11 Type II 7.3.3 Novasep Paclitaxel Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016) 7.3.4 Main Business/Business Overview 7.4 Samyang 7.4.1 Company Basic Information, Manufacturing Base and Its Competitors 7.4.2 Paclitaxel Product Type, Application and Specification 18.104.22.168 Type I 22.214.171.124 Type II 7.4.3 Samyang Paclitaxel Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016) 7.4.4 Main Business/Business Overview 7.5 Polymed 7.5.1 Company Basic Information, Manufacturing Base and Its Competitors 7.5.2 Paclitaxel Product Type, Application and Specification 126.96.36.199 Type I 188.8.131.52 Type II 7.5.3 Polymed Paclitaxel Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016) 7.5.4 Main Business/Business Overview 7.6 TAPI (Teva) 7.6.1 Company Basic Information, Manufacturing Base and Its Competitors 7.6.2 Paclitaxel Product Type, Application and Specification 184.108.40.206 Type I 220.127.116.11 Type II 7.6.3 TAPI (Teva) Paclitaxel Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016) 7.6.4 Main Business/Business Overview 7.7 Fresenius-kabi 7.7.1 Company Basic Information, Manufacturing Base and Its Competitors 7.7.2 Paclitaxel Product Type, Application and Specification 18.104.22.168 Type I 22.214.171.124 Type II 7.7.3 Fresenius-kabi Paclitaxel Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016) 7.7.4 Main Business/Business Overview 7.8 Southpharma 7.8.1 Company Basic Information, Manufacturing Base and Its Competitors 7.8.2 Paclitaxel Product Type, Application and Specification 126.96.36.199 Type I 188.8.131.52 Type II 7.8.3 Southpharma Paclitaxel Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016) 7.8.4 Main Business/Business Overview 7.9 Haiyao 7.9.1 Company Basic Information, Manufacturing Base and Its Competitors 7.9.2 Paclitaxel Product Type, Application and Specification 184.108.40.206 Type I 220.127.116.11 Type II 7.9.3 Haiyao Paclitaxel Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016) 7.9.4 Main Business/Business Overview 7.10 Huiang Biopharma 7.10.1 Company Basic Information, Manufacturing Base and Its Competitors 7.10.2 Paclitaxel Product Type, Application and Specification 18.104.22.168 Type I 22.214.171.124 Type II 7.10.3 Huiang Biopharma Paclitaxel Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016) 7.10.4 Main Business/Business Overview 7.11 Yunnan Hande 7.12 Hainan Yew Pharm Global QYResearch ( http://globalqyresearch.com/ ) is the one spot destination for all your research needs. Global QYResearch holds the repository of quality research reports from numerous publishers across the globe. Our inventory of research reports caters to various industry verticals including Healthcare, Information and Communication Technology (ICT), Technology and Media, Chemicals, Materials, Energy, Heavy Industry, etc. With the complete information about the publishers and the industries they cater to for developing market research reports, we help our clients in making purchase decision by understanding their requirements and suggesting best possible collection matching their needs.
Wucherpfennig T.,TU Braunschweig |
Schulz A.,TU Braunschweig |
Pimentel J.A.,National Autonomous University of Mexico |
Corkidi G.,National Autonomous University of Mexico |
And 6 more authors.
Bioprocess and Biosystems Engineering | Year: 2014
For the commercially established process of paclitaxel production with Taxus chinensis plant cell culture, the size of plant cell aggregates and phenotypic changes in coloration during cultivation have long been acknowledged as intangible parameters. So far, the variability of aggregates and coloration of cells are challenging parameters for any viability assay. The aim of this study was to investigate simple and non-toxic methods for viability determination of Taxus cultures in order to provide a practicable, rapid, robust and reproducible way to sample large amounts of material. A further goal was to examine whether Taxus aggregate cell coloration is related to general cell viability and might be exploited by microscopy and image analysis to gain easy access to general cell viability. The Alamar Blue assay was found to be exceptionally eligible for viability estimation. Moreover, aggregate coloration, as a morphologic attribute, was quantified by image analysis and found to be a good and traceable indicator of T. chinensis viability. © 2014 Springer-Verlag.
Wucherpfennig T.,TU Braunschweig |
Schilling J.,TU Braunschweig |
Sieblitz D.,Phyton Biotech GmbH |
Pump M.,Phyton Biotech GmbH |
And 3 more authors.
Engineering in Life Sciences | Year: 2012
In suspended culture, most relevant for biotechnological application, plant cells form aggregates. This phenomenon is of importance as it is related to productivity, leads to local heterogeneities, and might be a reason for the considerable shear sensitivity of these cultures. The valid measurement of plant cell aggregates, however, is not trivial, due to a rather large size distribution and measurement artifacts implied by the measuring method. In this study, laser diffraction was used as a novel method for characterization of Taxus chinensis cells, a major source for the antitumor agent paclitaxel. Aggregate size measured in shaking flask cultivations over 10 days revealed an increase during the growth phase of a batch cycle and a decrease during the stationary phase. During growth, the increase in bio dry weight was proportional to aggregate size. Laser diffraction was found superior to microscopy and image analysis, which had a tendency to underestimate aggregate size up to 20%. This novel approach provides a practicable, rapid, robust, and reproducible way to analyze a 100-fold more samples in considerably less time than image analysis and is therefore of especial value for quality control in industrial plant cell cultivation. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
News Article | April 21, 2016
Made by KIT: The microfluidic bioreactor technically reproduces plant tissue. The researchers now start a new project to make the next step. Credit: KIT Plants produce a number of substances that can be used to treat cancer, Alzheimer's or Parkinson's disease. Frequently, however, metabolic pathways to obtain the target substance are so complex that its biotechnological production is hardly effective and very expensive. Scientists of KIT now combine their expertise with the technical know-how of Phyton Biotech GmbH, the biggest producer of pharmaceutical ingredients with plant cells. With the help of a microfluidic bioreactor consisting of coupled modules, the scientists technically reproduce complex plant tissue to produce active substances against cancer or Alzheimer's disease more effectively and at lower costs. According to latest estimates, plants form about a million chemical substances, so-called secondary metabolites. Unlike amino acids or sugar, these secondary metabolites are not of vital importance. However, this vast pool of plant products contains a true treasure of pharmaceutically active substances that inhibit the growth of cancer cells or reduce the formation of Alzheimer-typical plaques in the brain. Many of these valuable ingredients cannot be produced synthetically. Often, they have to be extracted directly from wild plants and processed at high costs. Moreover, many of these plants are rare and endangered: For instance, the discovery of Taxol inhibiting cancer cells brought the Pacific yew to the brink of extermination. "For this reason, biotechnological approaches to producing the respective active substances are of high interest," Peter Nick, Professor for Molecular Cell Biology of KIT's Botanical Institute, says. Often, underlying metabolic pathways are highly complex. In the natural plant, the substance of interest mostly is the product of a long chain of steps with many converted interim products. The chemical processes required for this purpose do not necessarily take place in a single plant cell, but in several specialized cell types found in the plant tissue from the root to the leaf. Many years ago, Phyton demonstrated that plant-based medical substances, such as Taxol, can also be produced with minimum resources and sustainably by the cultivation of plant cells in the lab. "Certain substances, however, can be produced neither in a simple cell culture nor in microorganisms manipulated by genetic engineering, because metabolic pathways are too complex," Peter Nick says. "Within the framework of a new research project, we now want to technically reproduce plant tissue with various cell types using a so-called microfluidic bioreactor. It consists of several modules, in which one cell type each is cultivated. The modules are connected via channels. Metabolic products of one cell type then enter the next module for further processing without the different cell types being mixed. In the end, the target substance can be extracted from the flow and, hence, "harvested". The project is managed by the Jülich Project Management Agency (PtJ) and funded with EUR 750,000 by the Federal Ministry of Education and Research for a period of two years. The project partners are the Botanical Institute and the Institute of Microstructure Technology (both of KIT) and the company Phyton Biotech GmbH. Together, the three partners possess the expertise required for the project. The Botanical Institute contributes its knowledge of molecular cellular biology of plant cell cultures. Professor Andreas Guber and Dr. Ralf Ahrens of the Institute of Microstructure Technology are responsible for the development and fabrication of partial components of microfluidic bioreactors, their microassembly, and interconnection to a functioning system. The industry partner Phyton Biotech GmbH is a worldwide leading company in the area of plant cell fermentation and supplies the expertise and infrastructure needed to analyze potential applications on the industrial scale. "Cooperation with the experts of KIT will allow us to reach a new level of use of plant cells produced by controlled cultivation," Dr. Gilbert Gorr, Research and Development Director of Phyton, says. "Our joint objective is to make further natural substances accessible, which so far have been produced with large difficulties and high costs only." Phyton Biotech produces high-quality active pharmaceutical ingredients by plant cell fermentation (PCF) and is worldwide supplier of Paclitaxel and Docetaxel. The company has been inspected successfully by authorities, such as EDQM, EMA, FDA, KFDA, and TGA. Apart from production, Phyton also offers development services for customers. These cover the development of plant cell lines and fermentation processes for plant ingredients as well as the development of synthesis processes of complex substances. Explore further: Plant growth without light control: Synthetic photoreceptor stimulates germination and development