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Karagandy, Kazakhstan

Suleimen E.M.,Eurasian University | Dzhalmakhanbetova R.I.,Eurasian University | Pak R.N.,Phytochemistry Corporation | Kulyyasov A.T.,Phytochemistry Corporation | Adekenov S.M.,Phytochemistry Corporation
Chemistry of Natural Compounds | Year: 2014

Four new dialkylphosphonate derivatives 2-5 were prepared for the first time from the guaiane-type sesquiterpene lactone estafiatin (1), which was isolated from the aerial part of Achillea nobilis. Their structures were elucidated using PMR, 13C NMR, two-dimensional 1H-1H COSY, 13C-1H COLOC, and 31P-1H spectroscopy. The estafiatin phosphorylation reaction was highly chemo- and stereoselective. The antimicrobial activity of the prepared derivatives was studied. © 2014 Springer Science+Business Media. Source

Esenbaeva A.E.,Phytochemistry Corporation | Shul'Ts E.E.,RAS Institute of Organic Chemistry | Gatilov Yu.V.,RAS Institute of Organic Chemistry | Shakirov M.M.,RAS Institute of Organic Chemistry | And 4 more authors.
Chemistry of Natural Compounds | Year: 2013

13-Aryl-substituted derivatives of the germacranolide argolide were synthesized by a Heck reaction with arylhalides. The structure of (E)-13-(4-methoxyphenyl)-3-oxogermacra-1(10),11(13)-dien-6α,12-olide was proved by an x-ray crystal structure analysis. Analgesic activity was found in the acetic-acid writhing test for the 13-arylgermacranolides. © 2013 Springer Science+Business Media New York. Source

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