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Arzi A.,Physiology Research Center Jundishapour University of Medical science | Hemmati A.A.,Physiology Research Center Jundishapour University of Medical science | Karampour N.S.,Physiology Research Center Jundishapour University of Medical science | Nazari Z.,Ahvaz Jundishapur University of Medical Sciences | Baniahmad B.,International Medical University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

The present study investigated the antioxidant effect of wild celery seeds following reports in this regard. Wild celery seeds were provided by Isfahan Gol Daroo Co. and approved by the Department of Pharmacology. In order to prepare the extract, 70% ethanol was applied using the soaking method. Rats received 25, 50 and 100 mg/kg hydroxy extract of wild celery seed, respectively, and positive and negative control groups received 300 mg of aspirin and 5 ml/kg physiologic serum intraperitoneally, respectively. After half an hour, 100 ml of 1% carrageenan was subcutaneously injected to the paws of the rats in all groups and paw size changes were assessed using a plethysmometer every hour for 5 hours after the injection of carrageenan. All doses had an anti-inflammatory effect, and the 100 mg/kg dose of the extract had an anti-inflammatory effect similar to aspirin in all of the measured times. Because there was no significant difference between the anti-inflammatory effect of the 100 mg/kg dose and aspirin, the 100 mg/kg dose was recognized as the optimal dose. The hydroalcoholic extract of the seeds of wild celery has a dose-dependent anti-inflammatory effect. Source


Hemmati A.A.,Physiology Research Center Jundishapour University of Medical science | Arzi A.,Physiology Research Center Jundishapour University of Medical science | Karampour N.S.,Ahvaz Jundishapur University of Medical Sciences | Mehdipour S.,Ahvaz Jundishapur University of Medical Sciences
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Gastrointestinal complications caused by using non steroidal anti-inflammatory drugs (NSAIDs) stimulated researchers to pay more attention to certain herbs with anti-inflammatory effect. Olive has always been considered as an antihypertensive, anti atherosclerotic c, laxative, refrigerant and antioxidant drug in traditional medicine. This study aimed to investigate the anti-inflammatory activity of the Olea europaea l. fruit hydro alcoholic extract. The hydro alcoholic extract of Olive fruit was administered to male Wistar rats. Carrageenan-induced paw edema was used to evaluate the anti-inflammatory activity. The hydro alcoholic extract of Olea europaea l . Fruits (200, 300, 400, 500 mg/kg) or vehicle were administered intra peritoneally 30 minutes before the sub plantar injection of carrageenan. Intra peritoneal Aspirin (300 mg/kg) was used as standard drug. Doses of 200 and 300 mg/kg of the extract had a lower effect on reduction of paw's edema in comparison to aspirin in all measure hours; whereas, doses of 400 and 500 mg/kg of the extract, in comparison to aspirin, did not show any significant difference in reducing edema (p <0.05). Since there was no significant difference between doses of 400 and 500 mg/kg of the extract, the dose of 400 mg/kg was chosen as the best dose. These results indicated that the hydro alcoholic extract of Olive fruit has a potent anti-inflammatory action and confirmed that the extract contains an effective anti-inflammatory substance(s). Source

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