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Nanda A.,Pediatric Dermatology Unit | Alshalfan F.,Pediatric Dermatology Unit | Al-Otaibi M.,Mubarak Al Kabir Hospital | Al-Sabah H.,Dermatopathology Unit | Rajy J.M.,Photobiology Unit
American Journal of Dermatopathology | Year: 2013

Febrile ulceronecrotic Mucha-Habermann disease is a rare fulminant variant of pityriasis lichenoides et varioliformis acuta, characterized by a rapidly progressive course with predominant ulceronecrotic lesions associated with fever and systemic manifestations. It carries a great morbidity and is potentially fatal. The exact pathogenesis is not clear, and it has been proposed to be the result of hypersensitivity reaction to an infection. We report a patient with febrile ulceronecrotic Mucha-Habermann disease in a 12-year-old boy in whom the condition was most likely precipitated by parvovirus infection, and he showed a favorable response to a combination of prednisolone with narrow band ultraviolet B (NB-UVB) phototherapy. © 2013 Lippincott Williams & Wilkins.

Kata S.G.,0 Hollybush Road Cyncoed | Kata S.G.,Ninewells Hospital and Medical School | Kata S.G.,University of Dundee | Nabi G.,0 Hollybush Road Cyncoed | And 8 more authors.
Urologia Internationalis | Year: 2014

Objective: To explain our use of photodynamic diagnostic ureterorenoscopy, we provide a detailed description of the choice of photosensitiser, equipment needed, a safety profile, and pointers on our technique. Technique: Patients are given oral 5-aminolaevulinic acid (5-ALA) as a photosensitiser 3-4 h pre-operatively, and by using a Xenon blue light source, an eyepiece which blocks light below 450 nm which is fitted onto the ureterorenoscope, we are able to conduct a thorough photodiagnosis of the upper urinary tract. Conclusion: Our technique of photodynamic diagnostic ureterorenoscopy has shown that the sensitivity, specificity and detection rates of upper urinary tract lesions can be significantly increased with the use of oral 5-ALA. Therefore, we provide a detailed explanation of the use of oral 5-ALA photosensitiser, indications and contraindications of the technique in addition to equipment used and potential complications of the procedures. © 2014 S. Karger AG, Basel.

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