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Arona, Italy

Polettini A.-E.,University of Verona | Fortaner S.,European Commission - Joint Research Center Ispra | Farina M.,Phi Science | Groppi F.,University of Milan | And 5 more authors.
Bulletin of Environmental Contamination and Toxicology | Year: 2014

The 75Se internal bioavailability was investigated in microalgae, mussels and rats as biological experimental models. The 75Se accumulation from freshwater to microalgae [Scenedesmus obliquus (Turpin) Kützing], from freshwater to mussels (Unio mancus Lamark) and, finally, per os to rats (Rattus norvegicus Berkenhout) was followed using 75Se-labelled selenite looking at 75Se uptake, retention, intracellular distribution and binding with cellular biocomplexes. After exposure to 10, 50 and 500 μg Se L−1, the microalgae showed an inhibitory effect on population growth only at the highest concentration. Mussels exposed to 105 μg Se L−1 showed an accumulation of the element with time in all tissues. Intracellularly, Se was present in all subcellular fractions, especially in the cytosol. Rats were treated via oral administration with 5 μg Se rat−1. After 24 h, liver and kidney showed the highest Se concentration. © 2014 Springer Science+Business Media New York


Sabbioni E.,University of Chieti Pescara | Sabbioni E.,Ecsin European Center For The Sustainable Impact Of Nanotechnology Veneto Nanotech Scpa | Polettini A.-E.,University of Verona | Fortaner S.,European Commission - Joint Research Center Ispra | And 5 more authors.
Bulletin of Environmental Contamination and Toxicology | Year: 2014

75Se-selenite transfer was investigated in a phytoplankton-mussel-rat food chain model consisting of Scenedesmus obliquus (Turpin) Kützing, Unio mancus Lamark and Rattus norvegicus Berkenhout. 75Se-metabolized forms were investigated in order to identify potential critical steps in the food chain, as well as its relative bioavailability looking also at intracellular, cellular and organ partitioning. Tissue and intracellular distribution of 75Se in mussels fed with 75Se-S. obliquus was different compared to those exposed only to inorganic 75Se-selenite. The intracellular distribution of 75Se in the hepatopancreas and mantle of mussels fed 75Se-microalgae was similar to hepatic and renal distributions in rats, suggesting that their stomach dissociated larger 75Se-containing molecules. The 75Se partitioned from water (culture medium) to microalgae showing a bioconcentration factor of 435. The bottleneck in the trophic transfer of 75Se occurred between S. obliquus–U. mancus. From microalgae to mussels and subsequently to rats no bioaccumulation was verified. © 2014 Springer Science+Business Media New York


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Phi Science | Date: 2005-07-12

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