Sheffield, United Kingdom
Sheffield, United Kingdom

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Patent
Phase Focus | Date: 2012-07-13

Embodiments of the invention provide a method of determining a position of an object with respect to incident radiation, comprising iteratively determining at least one of an object function indicating one or more characteristics of an object and a probe function indicative of one or more characteristics of incident radiation, iteratively determining the position of the object, wherein the iteratively determining the position of the object comprises cross correlating first and second estimates of the object function or the probe function, determining a location of a peak of the cross correlation, and determining a translation deviation indicative of a difference in position of the object between the first and second estimates based on the location of the peak.


Patent
Phase Focus | Date: 2013-05-03

Embodiments of the present invention provide a method of providing image data for constructing an image of at least a region of a target object, comprising the steps of simultaneously recording, at a detector, a plurality of separable diffraction patterns formed by a respective portion of radiation scattered by the target object; and providing the image data via an iterative process responsive to the detected intensity of radiation.


Patent
Phase Focus | Date: 2012-01-25

A method and apparatus are disclosed for providing image data. The method includes the steps of providing image data for constructing an image of a region of a target object, comprising the steps of: providing incident radiation from a radiation source at a target object and, via at least one detector, detecting an intensity of radiation scattered by the target object; estimating an object function indicating at least one characteristic of a region of the target object; estimating a probe function indicating at least one characteristic of the incident radiation; providing image data via an iterative process responsive to the detected intensity of radiation scattered by the target object, wherein in said iterative process each of the object function and probe function are iteratively re-estimated step by step with a running estimate of the probe function being utilised to determine a running estimate of the object function associated with the target object.


Embodiments of the present invention provide a method (200) of providing image data for constructing an image of a region of a target object, comprising detecting, by at least one detector (40), at least a portion of radiation scattered by a target object (30) with the incident radiation (10) or an aperture at a predetermined probe position, determining an offset vector (203) for reducing an error associated with the probe position (201), estimating a wavefront (210) based on a probe function having the offset vector applied to the probe position, and providing image data responsive to the detected radiation.


Patent
Phase Focus | Date: 2013-01-24

Embodiments of the invention provide a method of determining one or more characteristics of a target object, comprising determining a first phase map for at least a region of a target object based on radiation directed toward the target object, determining one or more further phase maps for a sub-region of the region of the target object, determining a number of phase wraps for the sub-region based on a plurality of phase maps for the sub-region, and determining a characteristic of the region of the target object based on the number of phase wraps for sub-region and the first phase map. Embodiments of the invention also relate to a method of determining one or more characteristics of a target object, comprising determining a phase map for at least a region of a target object based on one or more diffraction patterns, determining a wavefront at a plane of the object based upon the phase map, and determining a refractive property of the object based on the wavefront.


Patent
Phase Focus | Date: 2011-06-27

A method of providing image data for constructing an image of a region of a target object, comprising providing a reference diffraction pattern of a reference target object; determining an initial guess for a probe function based upon the reference diffraction pattern; and determining, by an iterative process based on the initial guess for the probe function and an initial guess for an object function, image data for a target object responsive to an intensity of radiation detected by at least one detector.


Patent
Phase Focus | Date: 2011-12-02

Embodiments of the present invention provide a method of providing image data for constructing an image of a region of a target object, comprising providing incident radiation from a radiation source at a target object, detecting, by at least one detector, a portion of radiation scattered by the target object with the incident radiation or an aperture at first and second positions, and providing image data via an iterative process responsive to the detected radiation, wherein in said iterative process image data is provided corresponding to a portion of radiation scattered by the target object and not detected by the detector.


Patent
Phase Focus | Date: 2013-08-29

Embodiments of the present invention provide a method of estimating a magnitude of background radiation for each of a plurality of regions of a target object comprising providing an estimate of background radiation detected by a detector, measuring radiation scattered by the target object at the detector for each of a plurality of positions of the object with respect to the incident radiation, calculating, for each of the positions, an estimate of a wavefront at the detector, and determining, for each position, an estimated wavefront comprising a coherent contribution from radiation scattered by the target object and a background contribution, wherein said background contribution is at least partly incoherent with the radiation scattered by the target object. This method is particularly suitable for performing coherent diffractive imaging using ptychography where contribution from the incoherently scattered background is taken into account.


Patent
Phase Focus | Date: 2016-01-20

Embodiments of the invention provide a method of determining one or more characteristics of a target object, comprising recording one or more diffraction patterns at a detector, wherein each diffraction pattern is formed by a target object scattering incident radiation, determining a phase map for at least a region of the target object based on the one or more diffraction patterns, and determining a refractive property of the target object based on the phase map.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Smart - Proof of Concept | Award Amount: 100.00K | Year: 2012

The Phase Focus Virtual Lens® (otherwise known as ptychography) is a new microscopy method that eliminates the need for hardware focusing components, thereby removing the straitjacket imposed by the costs, limitations and imperfections of conventional lenses. Instead of lenses, the Virtual Lens image reconstruction process is performed by a sophisticated computer programme (algorithm.) Because it provides quantitative (numerical) information, and because it can extract the high information content often present in transparent specimens, the Virtual Lens has advantages in applications as diverse as live cell imaging and ophthalmic (contact) lens manufacture. The existing Virtual Lens algorithm relies on a two-dimensional mathematical approximation of the specimen. If the specimen’s structure is physically three-dimensional, or if it is thick, poor image quality can result. The purpose of this work, therefore, is to produce full tomographic quantitative images of low-contrast specimens of complex structures, using a new three-dimensional Virtual Lens algorithm. If successful, it is expected that this new method will be able to generate high quality and accurate information from such specimens without the use of stains, and from greater depths within the specimens than can be observed using conventional confocal microscopes. In addition, the technique is expected to be able to provide a new way to measure accurately, for manufacturing quality assurance purposes, the full three dimensional shape of lenses that are used in CD and DVD players, mobile phones, microscopes, telescopes and other products. It is anticipated that this work will therefore create new and improved products and processes for the benefit of UK industry and society at large.

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