Phase 1 Technology Corp

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Jahromi S.N.,Shiraz University | Jahromi S.N.,Phase 1 Technology Corp | Vadiee A.,Shiraz University of Technology | Yaghoubi M.,Shiraz University
Energy Procedia | Year: 2015

Thermal photovoltaic (PV/T) water based collectors are used to convert solar radiation to both thermal energy and electricity simultaneously. Along with energy analysis, exergy analysis is also useful for thermal systems such as PV/T to evaluate the "quality" of energy obtained from the system. Various types of PV/T collectors are available on the market. However, in this paper, a commercialized PV/T system is selected and exergy and economic analysis (exergoeconomics) is performed for a specific collector using known technical parameters and price for three cities in Iran with different insolation level. A MATLAB simulation program is prepared for this purpose, and it is cross validated using a former study on the same collector performed by TRNSYS and good agreement is observed. According to the results, exergy efficiency is obtained to be 9.7%, 9.6%, and 9.6% for the cities of Tabriz, Shiraz, and Esfahan respectively. An economic analysis is also performed using Net Present Value (NPV) method for the mentioned cities, and it concluded that with the specified economic parameters, the system is marginally economically feasible. This is found to be due to high capital investment costs as well as cheap available fossil fuel that is utilized widely in order to supply thermal and electrical energy demand in the studied cities. © 2015 The Authors. Published by Elsevier Ltd.


Kakar R.,GNA University | Kakar R.,Phase 1 Technology Corp
Journal of Solid Mechanics | Year: 2015

This paper deals with the propagation of magneto-thermo Rayleigh waves in a homogeneous viscoelastic half-space under initial stress. It has been observed that velocity of Rayleigh waves depends on viscosity, magnetic field, temperature and initial stress of the half-space. The frequency equation for Rayleigh waves under the effect of magnetic field, stress and temperature for both viscoelastic and elastic medium is first obtained by using classical theory of thermoelasticity and then computed numerically. The variation of phase velocity of Rayleigh waves with respect to initial hydrostatic stress in viscoelastic and elastic half-space is shown graphically. In the absence of various parameters of the medium, the obtained results are in agreement with classical results given by Caloi and Lockett. © 2015 IAU, Arak Branch.


Sharma M.,Teleradiology Solutions | Sharma M.,Phase 1 Technology Corp | Agrawal A.,Teleradiology Solutions
Indian Journal of Radiology and Imaging | Year: 2010

Chronic constipation can lead to fecal impaction. It can also rarely lead to catastrophic complications like perforation, colonic obstruction, and fecal peritonitis. We report a rare case of stercoral sigmoid colonic perforation with fecal peritonitis and pneumoperitoneum, which was diagnosed on preoperative CT scan.


Amrutha K.,Amrita University | Nanjan P.,Amrita University | Shaji S.K.,Amrita University | Sunilkumar D.,Amrita University | And 3 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2014

Seventeen flavonoids with different substitutions were evaluated for inhibition of nuclear factor-κB (NF-κB) signaling in the invasive breast cancer cell line MDA-MB-231. They were screened using an engineered MDA-MB-231 cell line reporting NF-κB activation. The modulation of expression of two NF-κB regulated genes involved in tumorigenesis, matrix metalloproteinase-9 (MMP-9), and cyclooxygenase-2 (COX-2) were also analyzed in these cells. Among the compounds tested, all except gossypetin and quercetagetin inhibited the activation of NF-κB, and the expression of MMP-9 and COX-2 to different degree. Methylated flavone, chrysoeriol (luteolin-3′-methylether), was found to be the most potent inhibitor of MMP-9 and COX-2 expressions. The effect of chrysoeriol on cell proliferation, cell cycle, apoptosis and metastasis was analyzed by established methods. Chrysoeriol caused cell cycle arrest at G2/M and inhibited migration and invasion of MDA-MB-231 cells. The structure-activity relations amongst the flavonoids as NF-κB signaling inhibitors was studied. The study indicates differences between the actions of various flavonoids on NF-κB activation and on the biological activities of breast cancer cells. Flavones in general, were more active than the corresponding flavonols. © 2014 Elsevier Ltd. All rights reserved.


Ananthula R.S.,Phase 1 Technology Corp | Muttineni Ravikumar,Osmania University | Mahmood S.K.,Osmania University | Kumar M.N.S.P.,Phase 1 Technology Corp
Journal of Molecular Modeling | Year: 2012

In recent years, there has been a growing interest in developing bacterial peptide deformylase (PDF) inhibitors as novel antibiotics. The purpose of the study is to generate a three-dimensional (3D) pharmacophore model by using diverse PDF inhibitors which is useful for designing of potential antibiotics. Twenty one structurally diverse compounds were considered for the generation of quantitative pharmacophore model using HypoGen of Catalyst, further model was validated using 78 compounds. Pharmacophore model demonstrated the importance of two acceptors, one donor and one hydrophobic feature toward the biological activity. The inhibitors were also docked into the binding site of PDF to comprehend the structural insights of the active site. Combination of ligand and structure based methods were used to find the potential antibiotics. © Springer-Verlag 2011.


Sarma R.,Phase 1 Technology Corp | Sinha S.,Phase 1 Technology Corp | Ravikumar M.,Phase 1 Technology Corp | Kumar M.K.,Phase 1 Technology Corp | Mahmood S.,Osmania University
Internet Electronic Journal of Molecular Design | Year: 2012

Motivation. Inhibition of the p38 MAP kinase pathway has been shown to be beneficial in the treatment of inflammatory diseases. A three-dimensional quantitative structure-activity relationship (3D-QSAR) model, based on molecular field analysis (MFA), was developed for 41 urea derivatives that are inhibitors of p38 mitogen-activated protein kinase (p38 MAPK). The 3D-QSAR model was developed using 32 compounds and its predictive ability was assessed using a test set of 9 compounds. Method. MFA studies were performed using the QSAR module of Cerius. Results. The predictive 3D-QSAR model has a conventional r2 = 0.901 and a cross-validated coefficient r2 cv = 0.799. The model was able to efficiently predict the activities of the compounds of the test set (r2 pred = 0.740), suggesting that it can be used for the development of new p38 MAPK inhibitor candidates, useful for treatment of chronic inflammatory states. Conclusions. The structural features indicated by this 3D-QSAR analysis provide a helpful guideline to design novel compounds with inhibitory activities against p38 MAPK. © 2008 BioChem Press.


Sharma M.,Phase 1 Technology Corp | Kaur J.,Phase 1 Technology Corp
ACM International Conference Proceeding Series | Year: 2015

In spam filtering techniques, the classification of emails are performed on the basis of a collection words that are extracted from the training set. The accuracy and performance of the classifier highly depends on features and length of feature space. Feature selection methods are used in such scenario for evaluating the best features for classification. In an attempt to develop strong spam filtering model we rank the features using Chi-Square feature ranking method and also investigate the effectiveness of feature length on classification accuracy. The results are promising and also the feature ranking method proposed is effective than other methods referred in the literature. © 2015 ACM.


PubMed | Amrita University and Phase 1 Technology Corp
Type: Journal Article | Journal: Bioorganic & medicinal chemistry letters | Year: 2014

Seventeen flavonoids with different substitutions were evaluated for inhibition of nuclear factor-B (NF-B) signaling in the invasive breast cancer cell line MDA-MB-231. They were screened using an engineered MDA-MB-231 cell line reporting NF-B activation. The modulation of expression of two NF-B regulated genes involved in tumorigenesis, matrix metalloproteinase-9 (MMP-9), and cyclooxygenase-2 (COX-2) were also analyzed in these cells. Among the compounds tested, all except gossypetin and quercetagetin inhibited the activation of NF-B, and the expression of MMP-9 and COX-2 to different degree. Methylated flavone, chrysoeriol (luteolin-3-methylether), was found to be the most potent inhibitor of MMP-9 and COX-2 expressions. The effect of chrysoeriol on cell proliferation, cell cycle, apoptosis and metastasis was analyzed by established methods. Chrysoeriol caused cell cycle arrest at G2/M and inhibited migration and invasion of MDA-MB-231 cells. The structure-activity relations amongst the flavonoids as NF-B signaling inhibitors was studied. The study indicates differences between the actions of various flavonoids on NF-B activation and on the biological activities of breast cancer cells. Flavones in general, were more active than the corresponding flavonols.


PubMed | Phase 1 Technology Corp
Type: Journal Article | Journal: Journal of molecular modeling | Year: 2012

In recent years, there has been a growing interest in developing bacterial peptide deformylase (PDF) inhibitors as novel antibiotics. The purpose of the study is to generate a three-dimensional (3D) pharmacophore model by using diverse PDF inhibitors which is useful for designing of potential antibiotics. Twenty one structurally diverse compounds were considered for the generation of quantitative pharmacophore model using HypoGen of Catalyst, further model was validated using 78 compounds. Pharmacophore model demonstrated the importance of two acceptors, one donor and one hydrophobic feature toward the biological activity. The inhibitors were also docked into the binding site of PDF to comprehend the structural insights of the active site. Combination of ligand and structure based methods were used to find the potential antibiotics.

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