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New Delhi, India

Sharma M.,Teleradiology Solutions | Sharma M.,Phase 1 Technology Corp | Agrawal A.,Teleradiology Solutions
Indian Journal of Radiology and Imaging | Year: 2010

Chronic constipation can lead to fecal impaction. It can also rarely lead to catastrophic complications like perforation, colonic obstruction, and fecal peritonitis. We report a rare case of stercoral sigmoid colonic perforation with fecal peritonitis and pneumoperitoneum, which was diagnosed on preoperative CT scan.

Amrutha K.,Amrita University | Nanjan P.,Amrita University | Shaji S.K.,Amrita University | Sunilkumar D.,Amrita University | And 3 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2014

Seventeen flavonoids with different substitutions were evaluated for inhibition of nuclear factor-κB (NF-κB) signaling in the invasive breast cancer cell line MDA-MB-231. They were screened using an engineered MDA-MB-231 cell line reporting NF-κB activation. The modulation of expression of two NF-κB regulated genes involved in tumorigenesis, matrix metalloproteinase-9 (MMP-9), and cyclooxygenase-2 (COX-2) were also analyzed in these cells. Among the compounds tested, all except gossypetin and quercetagetin inhibited the activation of NF-κB, and the expression of MMP-9 and COX-2 to different degree. Methylated flavone, chrysoeriol (luteolin-3′-methylether), was found to be the most potent inhibitor of MMP-9 and COX-2 expressions. The effect of chrysoeriol on cell proliferation, cell cycle, apoptosis and metastasis was analyzed by established methods. Chrysoeriol caused cell cycle arrest at G2/M and inhibited migration and invasion of MDA-MB-231 cells. The structure-activity relations amongst the flavonoids as NF-κB signaling inhibitors was studied. The study indicates differences between the actions of various flavonoids on NF-κB activation and on the biological activities of breast cancer cells. Flavones in general, were more active than the corresponding flavonols. © 2014 Elsevier Ltd. All rights reserved.

Jahromi S.N.,Shiraz University | Jahromi S.N.,Phase 1 Technology Corp | Vadiee A.,Shiraz University of Technology | Yaghoubi M.,Shiraz University
Energy Procedia | Year: 2015

Thermal photovoltaic (PV/T) water based collectors are used to convert solar radiation to both thermal energy and electricity simultaneously. Along with energy analysis, exergy analysis is also useful for thermal systems such as PV/T to evaluate the "quality" of energy obtained from the system. Various types of PV/T collectors are available on the market. However, in this paper, a commercialized PV/T system is selected and exergy and economic analysis (exergoeconomics) is performed for a specific collector using known technical parameters and price for three cities in Iran with different insolation level. A MATLAB simulation program is prepared for this purpose, and it is cross validated using a former study on the same collector performed by TRNSYS and good agreement is observed. According to the results, exergy efficiency is obtained to be 9.7%, 9.6%, and 9.6% for the cities of Tabriz, Shiraz, and Esfahan respectively. An economic analysis is also performed using Net Present Value (NPV) method for the mentioned cities, and it concluded that with the specified economic parameters, the system is marginally economically feasible. This is found to be due to high capital investment costs as well as cheap available fossil fuel that is utilized widely in order to supply thermal and electrical energy demand in the studied cities. © 2015 The Authors. Published by Elsevier Ltd.

Kakar R.,University | Kakar R.,Phase 1 Technology Corp
Journal of Solid Mechanics | Year: 2015

This paper deals with the propagation of magneto-thermo Rayleigh waves in a homogeneous viscoelastic half-space under initial stress. It has been observed that velocity of Rayleigh waves depends on viscosity, magnetic field, temperature and initial stress of the half-space. The frequency equation for Rayleigh waves under the effect of magnetic field, stress and temperature for both viscoelastic and elastic medium is first obtained by using classical theory of thermoelasticity and then computed numerically. The variation of phase velocity of Rayleigh waves with respect to initial hydrostatic stress in viscoelastic and elastic half-space is shown graphically. In the absence of various parameters of the medium, the obtained results are in agreement with classical results given by Caloi and Lockett. © 2015 IAU, Arak Branch.

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