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Jain R.,Chacha Nehru Bal Chikitsalaya | Jain R.,Phase 1 Technology Corp | Arora A.,Chacha Nehru Bal Chikitsalaya | Anand R.,Chacha Nehru Bal Chikitsalaya | And 3 more authors.
Indian Pediatrics | Year: 2017

Aim: To design and validate Hindi-language parent self-report developmental screening questionnaires for 9-month and 18-month-old Indian children. Design: Cross-sectional study Setting: Tertiary-care pediatric hospital from April 2014 to March 2016 Participants: In each age group (9-month and 18-month), 45 children were enrolled for designing of questionnaires (30 for obtaining parental observations of current development and 15 for pre-testing). For validation of tool, 100 children (60 low risk and 40 high risk) were enrolled in each age group. Methods: For designing, observations regarding current developmental milestones were obtained from parents and a list of all enumerated milestones was prepared. After detailed discussion by a team of developmental pediatricians, pediatric resident, clinical psychologist and language specialist, milestones were chosen for drafting of questionnaires. In each age group, drafts were pre-tested and required modifications were done. The final questionnaires contained 20 items each to be scored on a Likert scale (total score ranging from 20 to 60, a lower score indicating a higher risk of developmental delay). These questionnaires were validated against Developmental Assessment Scale for Indian Infants (DASII), a gold standard instrument. Results: On ROC analysis, the 9-month and 18-month screening tool had area under curve of 0.988 and 0.953, respectively, for detecting developmental delay. Score ≤50 on the 9-months questionnaire had sensitivity of 100% and specificity of 87.2%. Score ≤49 on the 18-months questionnaire had sensitivity of 91.4% and specificity of 88.7%. Conclusions: The new questionnaires have a promising role in developmental screening of children at the time of routine immunizations in our country. © 2017, Indian Academy of Pediatrics.


Ozor P.A.,University of Nigeria | Chigozirim P.O.,Phase 1 Technology Corp | Odukwe A.O.,University of Nigeria | Ume J.I.,University of Nigeria | Ozoegwu C.G.,University of Nigeria
International Journal of Environment and Waste Management | Year: 2017

Solid waste management practices are sometimes implemented with the key objective of taking solid wastes to central destination depots in no particular order. This method often results in different environmental, economic, social and regulatory difficulties. Specific waste management paradigms can provide instrumental control on operation of solid waste managers. This paper proposes decentralisation of landfill sites with a rigid assignment of such sites to demarcated geographical zones. The definite problem was inspired by a case not found in literature. Allocation of the proposed sites was formulated as an assignment problem and optimal schedules obtained using Hungarian method. The approach was tested on data from a real world case in Eastern Nigeria and compared to the existing practice utilised by the waste management authority. The results show that implementation of the proposed schedule can lead to 70% reduction in the subsisting cost of waste disposal with 21% return on capital investment. Copyright © 2017 Inderscience Enterprises Ltd.


Jahromi S.N.,Shiraz University | Jahromi S.N.,Phase 1 Technology Corp | Vadiee A.,Shiraz University of Technology | Yaghoubi M.,Shiraz University
Energy Procedia | Year: 2015

Thermal photovoltaic (PV/T) water based collectors are used to convert solar radiation to both thermal energy and electricity simultaneously. Along with energy analysis, exergy analysis is also useful for thermal systems such as PV/T to evaluate the "quality" of energy obtained from the system. Various types of PV/T collectors are available on the market. However, in this paper, a commercialized PV/T system is selected and exergy and economic analysis (exergoeconomics) is performed for a specific collector using known technical parameters and price for three cities in Iran with different insolation level. A MATLAB simulation program is prepared for this purpose, and it is cross validated using a former study on the same collector performed by TRNSYS and good agreement is observed. According to the results, exergy efficiency is obtained to be 9.7%, 9.6%, and 9.6% for the cities of Tabriz, Shiraz, and Esfahan respectively. An economic analysis is also performed using Net Present Value (NPV) method for the mentioned cities, and it concluded that with the specified economic parameters, the system is marginally economically feasible. This is found to be due to high capital investment costs as well as cheap available fossil fuel that is utilized widely in order to supply thermal and electrical energy demand in the studied cities. © 2015 The Authors. Published by Elsevier Ltd.


Kakar R.,GNA University | Kakar R.,Phase 1 Technology Corp
Journal of Solid Mechanics | Year: 2015

This paper deals with the propagation of magneto-thermo Rayleigh waves in a homogeneous viscoelastic half-space under initial stress. It has been observed that velocity of Rayleigh waves depends on viscosity, magnetic field, temperature and initial stress of the half-space. The frequency equation for Rayleigh waves under the effect of magnetic field, stress and temperature for both viscoelastic and elastic medium is first obtained by using classical theory of thermoelasticity and then computed numerically. The variation of phase velocity of Rayleigh waves with respect to initial hydrostatic stress in viscoelastic and elastic half-space is shown graphically. In the absence of various parameters of the medium, the obtained results are in agreement with classical results given by Caloi and Lockett. © 2015 IAU, Arak Branch.


Sharma M.,Teleradiology Solutions | Sharma M.,Phase 1 Technology Corp | Agrawal A.,Teleradiology Solutions
Indian Journal of Radiology and Imaging | Year: 2010

Chronic constipation can lead to fecal impaction. It can also rarely lead to catastrophic complications like perforation, colonic obstruction, and fecal peritonitis. We report a rare case of stercoral sigmoid colonic perforation with fecal peritonitis and pneumoperitoneum, which was diagnosed on preoperative CT scan.


Amrutha K.,Amrita University | Nanjan P.,Amrita University | Shaji S.K.,Amrita University | Sunilkumar D.,Amrita University | And 3 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2014

Seventeen flavonoids with different substitutions were evaluated for inhibition of nuclear factor-κB (NF-κB) signaling in the invasive breast cancer cell line MDA-MB-231. They were screened using an engineered MDA-MB-231 cell line reporting NF-κB activation. The modulation of expression of two NF-κB regulated genes involved in tumorigenesis, matrix metalloproteinase-9 (MMP-9), and cyclooxygenase-2 (COX-2) were also analyzed in these cells. Among the compounds tested, all except gossypetin and quercetagetin inhibited the activation of NF-κB, and the expression of MMP-9 and COX-2 to different degree. Methylated flavone, chrysoeriol (luteolin-3′-methylether), was found to be the most potent inhibitor of MMP-9 and COX-2 expressions. The effect of chrysoeriol on cell proliferation, cell cycle, apoptosis and metastasis was analyzed by established methods. Chrysoeriol caused cell cycle arrest at G2/M and inhibited migration and invasion of MDA-MB-231 cells. The structure-activity relations amongst the flavonoids as NF-κB signaling inhibitors was studied. The study indicates differences between the actions of various flavonoids on NF-κB activation and on the biological activities of breast cancer cells. Flavones in general, were more active than the corresponding flavonols. © 2014 Elsevier Ltd. All rights reserved.


Ananthula R.S.,Phase 1 Technology Corp | Muttineni Ravikumar,Osmania University | Mahmood S.K.,Osmania University | Kumar M.N.S.P.,Phase 1 Technology Corp
Journal of Molecular Modeling | Year: 2012

In recent years, there has been a growing interest in developing bacterial peptide deformylase (PDF) inhibitors as novel antibiotics. The purpose of the study is to generate a three-dimensional (3D) pharmacophore model by using diverse PDF inhibitors which is useful for designing of potential antibiotics. Twenty one structurally diverse compounds were considered for the generation of quantitative pharmacophore model using HypoGen of Catalyst, further model was validated using 78 compounds. Pharmacophore model demonstrated the importance of two acceptors, one donor and one hydrophobic feature toward the biological activity. The inhibitors were also docked into the binding site of PDF to comprehend the structural insights of the active site. Combination of ligand and structure based methods were used to find the potential antibiotics. © Springer-Verlag 2011.


Sharma M.,Phase 1 Technology Corp | Kaur J.,Phase 1 Technology Corp
ACM International Conference Proceeding Series | Year: 2015

In spam filtering techniques, the classification of emails are performed on the basis of a collection words that are extracted from the training set. The accuracy and performance of the classifier highly depends on features and length of feature space. Feature selection methods are used in such scenario for evaluating the best features for classification. In an attempt to develop strong spam filtering model we rank the features using Chi-Square feature ranking method and also investigate the effectiveness of feature length on classification accuracy. The results are promising and also the feature ranking method proposed is effective than other methods referred in the literature. © 2015 ACM.


PubMed | Amrita University and Phase 1 Technology Corp
Type: Journal Article | Journal: Bioorganic & medicinal chemistry letters | Year: 2014

Seventeen flavonoids with different substitutions were evaluated for inhibition of nuclear factor-B (NF-B) signaling in the invasive breast cancer cell line MDA-MB-231. They were screened using an engineered MDA-MB-231 cell line reporting NF-B activation. The modulation of expression of two NF-B regulated genes involved in tumorigenesis, matrix metalloproteinase-9 (MMP-9), and cyclooxygenase-2 (COX-2) were also analyzed in these cells. Among the compounds tested, all except gossypetin and quercetagetin inhibited the activation of NF-B, and the expression of MMP-9 and COX-2 to different degree. Methylated flavone, chrysoeriol (luteolin-3-methylether), was found to be the most potent inhibitor of MMP-9 and COX-2 expressions. The effect of chrysoeriol on cell proliferation, cell cycle, apoptosis and metastasis was analyzed by established methods. Chrysoeriol caused cell cycle arrest at G2/M and inhibited migration and invasion of MDA-MB-231 cells. The structure-activity relations amongst the flavonoids as NF-B signaling inhibitors was studied. The study indicates differences between the actions of various flavonoids on NF-B activation and on the biological activities of breast cancer cells. Flavones in general, were more active than the corresponding flavonols.

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