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Alexandria, Egypt

Pharos University in Alexandria جامعة فاروس بالإسكندرية is a non-governmental and profit making university in Alexandria, Egypt.Pharos University obtained the license from the Egyptian supreme council of private universities to operate in the academic year of 2006 / 2007. It includes eleven faculties:Pharmacy and Drug Manufacturing, Dentistry, Engineering, Languages and translationFinancial and Administrative science, Legal Studies and international Relations, Tourism and Hotel management, Allied Medical science, Mass Communication, Physical Therapy, Arts and Design. Wikipedia.

Cisplatin is an effective chemotherapeutic agent successfully used in the treatment of a wide range of solid tumors, while its usage is limited due to its nephrotoxicity. The present study was undertaken to examine the effectiveness of ginseng to ameliorate the renal nephrotoxicity, damage in kidney genomic DNA, tumor necrosis factor-α, interleukin 6, tumor suppressor P53, histological changes and oxidative stress induced by cisplatin in rats. Cisplatin caused renal damage, including DNA fragmentation, upregulates gene expression of tumor suppressor protein p53 and tumor necrosis factor-α and IL-6. Cisplatin increased the levels of kidney TBARS, xanthine oxidase, nitric oxide, serum urea and creatinine. Cisplatin decreased the activities of antioxidant enzymes (GST, GPX, CAT and SOD), ATPase and the levels of GSH. A microscopic examination showed that cisplatin caused kidney damage including vacuolization, severe necrosis and degenerative changes. Ginseng co-treatment with cisplatin reduced its renal damage, oxidative stress, DNA fragmentation and induced DNA repair processes. Also, ginseng diminished p53 activation and improved renal cell apoptosis and nephrotoxicity. It can be concluded that, the protective effects of ginseng against cisplatin induced-renal damage was associated with the attenuation of oxidative stress and the preservation of antioxidant enzymes. © 2015 Elsevier Ltd.

Masoud M.S.,Alexandria University | Ali A.E.,Damanhour University | Abd El-Kaway M.Y.,Pharos University in Alexandria
Journal of Thermal Analysis and Calorimetry | Year: 2014

Six solid Pd(II) and Hg(II) complexes of some purines and pyrimidines have been prepared and characterized by elemental analyses, IR, UV-Vis spectra, magnetic measurements, and thermal analyses. The data suggest tetrahedral and square planar geometries for mercury and palladium complexes, respectively. The thermal behavior of the complexes has been studied applying TG, DTA, and DSC techniques, and the thermodynamic parameters and mechanisms of the decompositions were evaluated. The ΔS values of the decomposition steps of the metal complexes indicated that the activated fragments have more ordered structure than the undecomposed complexes, and/or the decomposition reactions are slow. The thermal processes proceeded in complicated mechanisms where the bond between the central metal ion and the ligands dissociates after losing small molecules such as H2O, HCl or C=O. The palladium adenine complex is ended with the metal as a final product. However, the thermal reactions of the other five palladium and mercury pyrimidines complexes are ended with metal bonded to O, N, or S of the pyrimidine ring. © 2013 Akadémiai Kiadó, Budapest, Hungary.

Wen M.M.,Pharos University in Alexandria
Discovery medicine | Year: 2011

Many therapeutic drugs are difficult to reach the central nervous system (CNS) from the systemic blood circulation because the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) form a very effective barrier which prevents most molecules from passing through. To bypass BBB, drugs can be delivered through olfactory region for nose-to-brain targeting. Peptide and protein drugs have been developed for the treatment of various neurodegenerative diseases. Drug delivery of these therapeutic proteins is facing several challenges because of the instability, high enzymatic metabolism, low gastrointestinal absorption, rapid renal elimination, and potential immunogenicity. New genetically engineered biotechnology products, such as recombinant human nerve growth factor, human VEGF, and interferons, are now possible to be delivered into the brain from the non-invasive intranasal route. For gene therapy, intranasal route is also a promising alternative method to deliver plasmid DNA to the brain. This review provides an overview of strategies to improve the drug delivery to the brain and the latest development of protein, peptide, and gene intranasal delivery for brain targeting.

Hazzaa R.,Pharos University in Alexandria | Hussein M.,Alexandria University
Environmental Technology and Innovation | Year: 2015

The use of agriculture solid waste as low-cost adsorbents is considered as an ecofriendly adsorbent due to their contribution in the reduction of costs for waste disposal. The present study investigates the adsorption efficiency of raw olive stone (OS) and activated carbon prepared from Egyptian olive stones (OSAC). Batch adsorption experiments were conducted under varying conditions of contact time, initial concentration of methylene blue dye (MB), adsorbent dosage, pH and temperature. The experimental equilibrium data were examined using Langmuir, Freundlich, Temkin, Dubinin-Radushkevich, and Harkins-Jura isotherms. The adsorption kinetic dye was analyzed using pseudo-first order, pseudo-second order and the intraparticle diffusion model. The results showed that the percentage of dye removal increased as the temperature increased but it decreased with the increase in initial dye concentration. The optimum pH required for maximum adsorption was found to be 5. Kinetic studies showed that the adsorption MB onto OS and OSAC followed pseudo-second order kinetic model. The results indicated that olive stone activated carbon could be used as a low-cost adsorbent for the removal of methylene blue from aqueous solution. © 2015 Elsevier B.V.

Masoud M.S.,Alexandria University | Abd El-Kaway M.Y.,Alexandria University | Abd El-Kaway M.Y.,Pharos University in Alexandria
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2013

Copper guanine and barbital complexes were prepared and characterized by elemental analyses and spectral measurements. The data typified the formation of stoichiometries 1:1 (M:L) with possible Cu-Cu interaction " association". The complexes are with different geometries: square planar, square pyramidal and tetrahedral. The mode of bonding was identified by IR spectra. EPR spectra of the powdered complexes were recorded at X band at the room temperature. Different ESR parameters were calculated and discussed: g //, g⊥, A//, 〈g〉, G, F, K, α2. Molecular modeling techniques and quantum chemical methods have been performed for copper complexes to correlate the chemical structures of the complexes with their physical molecular properties. Bond lengths, bond orders, bond angles, dihedral angles, close contact, dipole moment (μ), sum of the total negative charge (STNC), electronegativity (χ), chemical potential (Pi), global hardness (η), softness (σ), the highest occupied molecular orbital energy (EHOMO), the lowest unoccupied molecular orbital energy (ELUMO) and the energy gap (ΔE) were calculated using PM3 semi-empirical and Molecular Mechanics (MM+) methods. The study displays a good correlation between the theoretical and experimental data which confirms the reliability of the quantum chemical methods. © 2012 Elsevier B.V. All rights reserved.

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