Pharmorphix Ltd

Milton Keynes, United Kingdom

Pharmorphix Ltd

Milton Keynes, United Kingdom

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Lancaster R.W.,University College London | Harris L.D.,University College London | Pearson D.,Pharmorphix Ltd | Pearson D.,8 9 Spire Green Center
CrystEngComm | Year: 2011

We describe a unique experiment whereby analysis of fifty-year old samples of progesterone shows that a metastable, 'disappearing' polymorph contains several impurities that are not found in the stable form. © 2011 The Royal Society of Chemistry.


Grepioni F.,University of Namur | Wouters J.,University of Bologna | Braga D.,University of Namur | Nanna S.,University of Namur | And 7 more authors.
CrystEngComm | Year: 2014

Mechanochemical and solution based reactions of solid brivaracetam (BRV) and seletracetam (SEL), antiepileptic drugs from UCB's pipeline, with the inorganic salts MgCl2 and CaCl2, yield ionic co-crystals with changed or improved physico-chemical properties with respect to pure drugs (melting point, hygroscopicity, crystal morphology). All co-crystals are characterized via a combination of solid-state techniques, i.e. single crystal and powder X-ray diffraction, variable temperature X-ray diffraction, DSC, TGA and hot-stage microscopy (HSM). © the Partner Organisations 2014.


Eberlin A.R.,Pharmorphix Ltd | Eddleston M.D.,University of Cambridge | Frampton C.S.,Pharmorphix Ltd
Acta Crystallographica Section C: Crystal Structure Communications | Year: 2013

New methanesulfonic acid salt forms of the anticonvulsant and analgesic active pharmaceutical ingredient carbamazepine and its closely related structural analogue 10,11-dihydrocarbamazepine have been prepared and characterized by single-crystal X-ray diffraction at 120 and 100 K, respectively {namely [(5H-dibenzo[b,f]azepin-5-yl)(hydroxy)methylidene]azanium methanesulfonate, C15H13N2O+· CH3SO3 -, and [(10,11-dihydro-5H-dibenzo[b,f] azepin-5-yl)(hydroxy)methylidene]azanium methanesulfonate, C15H 15N2O+·CH3SO3 -}. In light of the structural information obtained, the crystal structure of the carbamazepine trifluoroacetic acid monosolvate [dibenzo[b,f]azepine-5-carboxamide-trifluoroacetic acid (1/1), C 15H12N2O·CF3COOH] was redetermined at 100 and 270 K, and from this data it was concluded that the protonation state for this solvate species is best described as in an 'intermediate state' with the acidic proton located almost at the mid-point between the acid and base. © 2013 International Union of Crystallography.


Andrews K.G.,Imperial College London | Frampton C.S.,Pharmorphix Ltd | Spivey A.C.,Imperial College London
Acta Crystallographica Section C: Crystal Structure Communications | Year: 2013

The identity of the major product of Ru-catalysed alkene metathesis of two polyene substrates has been determined using density functional theory (DFT) NMR prediction, a 1H-1H Total Correlated Spectroscopy (TOCSY) NMR experiment and ultimately by single-crystal X-ray crystallography. The substrates were designed as those that would potentially allow expedient access to the trans-decalin skeleton of the natural product (-)-euonyminol, but the product was found to be a bis-cyclopentenyl-β-cyanohydrin [1-(1-hydroxycyclopent-3-en-1-yl)cyclopent-3-ene-1-carbonitrile, C 11H13NO] rather than the trans-2,3,6,7-dehydrodecalin- β-cyanohydrin. © 2013 International Union of Crystallography.


PubMed | Pharmorphix Ltd
Type: Journal Article | Journal: Acta crystallographica. Section C, Crystal structure communications | Year: 2013

New methanesulfonic acid salt forms of the anticonvulsant and analgesic active pharmaceutical ingredient carbamazepine and its closely related structural analogue 10,11-dihydrocarbamazepine have been prepared and characterized by single-crystal X-ray diffraction at 120 and 100K, respectively {namely [(5H-dibenzo[b,f]azepin-5-yl)(hydroxy)methylidene]azanium methanesulfonate, C15H13N2O(+)CH3SO3(-), and [(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)(hydroxy)methylidene]azanium methanesulfonate, C15H15N2O(+)CH3SO3(-)}. In light of the structural information obtained, the crystal structure of the carbamazepine trifluoroacetic acid monosolvate [dibenzo[b,f]azepine-5-carboxamide-trifluoroacetic acid (1/1), C15H12N2OCF3COOH] was redetermined at 100 and 270K, and from this data it was concluded that the protonation state for this solvate species is best described as in an `intermediate state with the acidic proton located almost at the mid-point between the acid and base.

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