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Bharathi K.,Sri Padmavathi Mahila University | Omprakash G.,PharmaZell R and D India Private Ltd
Asian Journal of Chemistry | Year: 2011

A series of 2,3-substituted-4-phenyl-1,3-oxazolidine derivatives were synthesized from DL-(±)-phenyl glycine. DL-(±)-Phenyl glycine was reduced to the corresponding alcohol, which was then condensed with different aldehydes to form Schiff bases, which are then educed and further condensed with different substituted aldehydes to give the oxazolidine derivatives. The synthesized compounds are characterized by 1H NMR, IR and mass spectral analysis. All the compounds were investigated for cardiac activity while all the compounds show significant activity.


Umanadh Y.,Pharma Zell RandD India Private Ltd | Umanadh Y.,Jawaharlal Nehru University | Reddy N.S.,Pharma Zell RandD India Private Ltd | Mukkanti K.,Jawaharlal Nehru University | Omprakash G.,Pharma Zell RandD India Private Ltd
Asian Journal of Chemistry | Year: 2015

A new complex of perchloric acid absorbed on silica gel (doped silica gel) and dichloromethane was found to be very effective for converting ketoximes into their corresponding amides or lactams with excellent conversion via the Beckmann rearrangement. This method offers significant advantages such as efficiency and mild reaction conditions with shorter reaction time. © 2015, Chemical Publishing Co. All rights reserved.


Suneel Kumar K.,PharmaZell R and D India Private Ltd | Tatendra Reddy K.,PharmaZell R and D India Private Ltd | Vamsikanth A.,PharmaZell R and D India Private Ltd | Omprakash G.,PharmaZell R and D India Private Ltd | Dubey P.K.,JNTUH College of Engineering
Der Pharma Chemica | Year: 2011

The synthesis and characterization of some novel isoxazoles derivatives have been presented. Acylation of resorcinol followed by nuclear prenylation with isoprene gives Chroman. Chroman on treatment with p-substituted benzaldehydes affords substituted chalcones. Isoxazoles have been prepared from chalcones by treating with hydroxylamine hydrochloride. The structure of isoxazoles has been characterized by spectral analysis.


Reddy K.T.,PharmaZell R and D India Private Ltd | Kumar K.S.,PharmaZell R and D India Private Ltd | Omprakash G.,PharmaZell R and D India Private Ltd | Dubey P.K.,University of Hyderabad
Synthetic Communications | Year: 2013

S-(+)-Clopidogrel bisulfate [(S-(+)-methyl 2-(2-chlorophenyl)-2-(6, 7-dihydrothieno[3, 2-c]pyridin-5(4H)-yl)acetate bisulfate)] is a platelet aggregation inhibitor drug. S-(+)-Clopidogrel bisulfate is prepared by different synthetic approaches in the literature. In almost all the approaches the major impurities known in the literature (A, B, and C) are also listed in the U.S. pharmacopoeia. The control of these pharmaceutical impurities is currently a critical issue to the pharmaceutical industry. In this article, a description of these impurities and their origins in the S-(+)-clopidogrel bisulfate process are presented along with the preparation of impurity B. © 2013 Copyright Taylor and Francis Group, LLC.


Tatendra Reddy K.,Pharma Zell R and D India Private Ltd | Tatendra Reddy K.,University of Hyderabad | Suneel Kumar K.,Pharma Zell R and D India Private Ltd | Omprakash G.,Pharma Zell R and D India Private Ltd | Dubey P.K.,University of Hyderabad
Der Pharma Chemica | Year: 2011

A new processdeveloped for the synthesis of enantiomerically pure R-(+)-N-propargyl-1-aminoindan mesylate(Rasagiline mesylate) by using K 2HPO 4/Triethylbenzylammonium chloride (TEBAC) as a reagent. This approach controls the formation of other isomerS-(-)-N-propargyl-1-aminoindane. This new process may be useful for the preparation of enantiomerically pure Rasagiline mesylatein commercial scale with good yields.


Tatendra Reddy K.,Pharma Zell R and D India Private Ltd | Tatendra Reddy K.,University of Hyderabad | Suneel Kumar K.,Pharma Zell R and D India Private Ltd | Omprakash G.,Pharma Zell R and D India Private Ltd | Dubey P.K.,University of Hyderabad
Indian Journal of Heterocyclic Chemistry | Year: 2012

A facile synthesis of Carvedilol via a key β-amino alcohol intermediate is described and this approach avoids the formation of bis side product (impurity B).


Tatendra Reddy K.,PharmaZell R and D India Private Ltd | Tatendra Reddy K.,University of Hyderabad | Suneel Kumar K.,PharmaZell R and D India Private Ltd | Omprakash G.,PharmaZell R and D India Private Ltd | Dubey P.K.,University of Hyderabad
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2014

A facile synthesis of Carvedilol via a key 2-(2-methoxyphenoxy) ethyl 4-methylbenzenesulfonate intermediate is described and this approach avoids the formation of bis side product (impurity-B) due to weak basic conditions and also operationally suitable for industrial application.

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