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Yantai, China

Liu W.-Z.,Pharmacy of College | Ma L.-Y.,Pharmacy of College | Liu D.-S.,Pharmacy of College | Huang Y.-L.,Pharmacy of College | And 5 more authors.
Organic Letters | Year: 2014

Peniciketals A-C (1-3), three new spiroketals with a benzo-fused 2,8-dioxabicyclo[3.3.1]nonane moiety, were isolated from the saline soil derived fungus Penicillium raistrichii. Their structures including absolute configurations were established by NMR, X-ray diffraction, and ECD calculations. Their cytotoxicities were tested against A549, HL-60, and K562 cell lines, and 1-3 showed the selective effects on HL-60 cells with IC50 values of 3.2, 6.7, and 4.5 μM, respectively. © 2013 American Chemical Society. Source

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