Pharmacogenetic Research Clinic

Toronto, Canada

Pharmacogenetic Research Clinic

Toronto, Canada
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Kapelski P.,Poznan University of Medical Sciences | Skibinska M.,Poznan University of Medical Sciences | Maciukiewicz M.,Pharmacogenetic Research Clinic | Pawlak J.,Poznan University of Medical Sciences | And 2 more authors.
Journal of Neuroimmunology | Year: 2016

Schizophrenia is a heterogeneous disorder and its etiology remains incompletely elucidated. Among possible causes, immunological factors have been implicated in its pathogenesis and course. Interleukin-10 (IL10) and it's receptor IL10RA may play an important role for immunological aspects in etiologies of major psychiatric disorders including schizophrenia. The aim of this study was to perform a transmission disequilibrium test (TDT) on a group of 146 schizophrenia trios from the Polish population. Functional polymorphisms from IL10 (rs1800872, rs1800871, rs1800896, rs1800890, and rs6676671) and IL10RA (rs3135932 and rs2229113) genes were analyzed. A lack of association with schizophrenia was detected for IL10 and IL10RA single polymorphisms and haplotypes. © 2016 Elsevier B.V.


PubMed | Pharmacogenetic Research Clinic and Poznan University of Medical Sciences
Type: | Journal: Journal of neuroimmunology | Year: 2016

Schizophrenia is a heterogeneous disorder and its etiology remains incompletely elucidated. Among possible causes, immunological factors have been implicated in its pathogenesis and course. Interleukin-10 (IL10) and its receptor IL10RA may play an important role for immunological aspects in etiologies of major psychiatric disorders including schizophrenia. The aim of this study was to perform a transmission disequilibrium test (TDT) on a group of 146 schizophrenia trios from the Polish population. Functional polymorphisms from IL10 (rs1800872, rs1800871, rs1800896, rs1800890, and rs6676671) and IL10RA (rs3135932 and rs2229113) genes were analyzed. A lack of association with schizophrenia was detected for IL10 and IL10RA single polymorphisms and haplotypes.


Huang E.,King's College | Huang E.,Pharmacogenetic Research Clinic | Maciukiewicz M.,Pharmacogenetic Research Clinic | Zai C.C.,Pharmacogenetic Research Clinic | And 9 more authors.
Pharmacogenomics | Year: 2016

Aim: The recent Psychiatric Genomics Consortium genome-wide association study identified an SNP, rs2514218, located 47kb upstream of the DRD2 gene to be associated with risk for schizophrenia (p = 2.75e-11). Since all antipsychotics bind to dopamine D2 receptors, we examined rs2514218 in relation to response to antipsychotic treatment. Patients & methods: We investigated the SNP in relation to treatment response in a prospective study consisting of 208 patients (151 Caucasians, 42 African-Americans and 15 others) treated with clozapine for 6 months. Results: rs2514218 was associated with total score change in the brief psychiatric rating scale under an additive model (pcorr= 0.033). Conclusion: Our finding provides evidence for rs2514218 association with antipsychotic response, but further replication is required before firm conclusions can be drawn. © 2016 Future Medicine Ltd.

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