Zhang N.,University of Maryland Baltimore County |
Zhang N.,Pharmaceutics International Inc. Pii |
Zhang P.,University of Maryland Baltimore County |
Zhang P.,Pharmaceutics International Inc. Pii |
And 4 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2014
Examples of ring-expanded nucleosides (RENs), represented by general structures 1 and 2, exhibited dual anti-HCV and anti-HIV activities in both cell culture systems and the respective target enzyme assays, including HCV NTPase/helicase and human RNA helicase DDX3. Since HCV is a leading co-infection in late stage HIV AIDS patients, often leading to liver cirrhosis and death, the observed dual inhibition of HCV and HIV by the target nucleoside analogues has potentially beneficial implications in treating HIV patients infected with HCV. © 2014 Elsevier Ltd. All rights reserved. Source