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Irannejad H.,Pharmacy Development | Amini M.,Pharmacy Development | Khodagholi F.,Shahid Beheshti University of Medical Sciences | Ansari N.,Pharmacy Development | And 4 more authors.
Bioorganic and Medicinal Chemistry | Year: 2010

The role of novel triazine derivatives against oxidative stress exerted by hydrogen peroxide on differentiated rat pheochromocytoma (PC12) cell line was examined and a consistent protection from H2O2-induced cell death, associated with a marked reduction in caspase-3 activation, was observed. Moreover, activation of NF-κB, a known regulator of a host of genes that involves in specific stress and inflammatory responses by H2O2, was greatly impaired by triazine pretreatment in differentiated PC12 cells. Neuroprotective effect of such compounds may represent a promising approach for treatment of neurodegenerative diseases. © 2010 Elsevier Ltd. All rights reserved. Source


Ganjali M.R.,University of Tehran | Hosseini M.,University of Tehran | Pirali-Hamedani M.,Tehran University of Medical Sciences | Pirali-Hamedani M.,Pharmaceutical science Research Center | Zamani H.A.,Islamic Azad University at Quchan
International Journal of Electrochemical Science | Year: 2011

Given the results of our previous studies indicating a relatively strong interaction between 2-{[(6-aminopyridin-2-yl) imino] methyl}-phenol (APIMP) and Nd(III) ions, the ligand was incorporated, as the sensing material, into a nano-composite carbon paste electrodes which were prepared using functionalized multi-walled carbon nanotube (MWCNT-NH2), nanosilica (NS), graphite, and an room temperature ionic liquid namely 1-n-butyl-3-methylimidazolium tetrafluoroborate [bmim]BF4 (RTIL). The electrodes composed of 2%NS, 5% MWCNT-NH2, 20% APIMP, 20% RTIL, and 53% graphite powder were found to show the optimum behavior. The sensor shows a Nernstian response of (19.8±0.12 mV decade-1) in the concentration window of 1.0×10-6-1.0×10-2 M with a detection limit of 8.0×10-7 M. The response of the sensor was found to be stable in the pH of 4.0-8.0 and the nano-composite based Nd(III) sensors displayed good selectivity with respect to a number of lanthanide and transition metal ions as well as a rather long lifetime. © 2011 by ESG. Source


Norouzi P.,University of Tehran | Pirali-Hamedani M.,Tehran University of Medical Sciences | Pirali-Hamedani M.,Pharmaceutical science Research Center | Ranaei-Siadat S.O.,Tehran University of Medical Sciences | Ganjali M.R.,University of Tehran
International Journal of Electrochemical Science | Year: 2011

It was found that N-[(Z)-1-(2-thienyl)methylidene]-N-[4-(4-{[(Z)-1-(2-thienyl)methylidene] amino}benzyl)phenyl] amine (TBPA) can form a selective complex with lutetium ions respect to other lanthanide ions based on our previous study. To have a long-term stable electrode for potentiometric uses, TBPA was applied as an ionophore in preparation of a nanocomposite carbon paste electrode. The pastes were prepared using functionalized multi-walled carbon nanotube (MWCNT-NH2), nanosilica (NS), graphite, and room temperature ionic liquid (RTIL). The carbon paste electrode composed of 5% MWCNT-NH2, 1%NS, 25% TBPA, 20% RTIL, and 49% graphite powder showed the best response. Nernstian response of (19.8±0.2 mV decade-1) in the concentration range of 1.0× 10-6-1.0×10-2 M with a detection limit of 9.5×10-7 M was achieved. The response of the electrode was pH independent in the range of 3.5-9.0. The proposed Lu(III) nano-composite carbon paste sensor displayed good selectivity, fast response time and long lifetime. © 2011 by ESG. Source


Faridbod F.,Tehran University of Medical Sciences | Zamani H.A.,Islamic Azad University at Quchan | Hosseini M.,University of Tehran | Pirali-Hamedani M.,Tehran University of Medical Sciences | And 3 more authors.
International Journal of Electrochemical Science | Year: 2011

Using multi-walled carbon nanotube (MWCNT) and ionic liquid (IL) in the composition of carbon paste electrodes cause improvement in their characterizations. Previous solution studies showed a selective interaction between N,N-bis(a-methylsalicylidene)diethylenetriamine (BMT) and Pr3+ ions respect to other lanthanide ions. To have an electrode with enhanced mechanical resistant in analysis, BMT incorporation of MWCNTs and ionic liquid in carbon paste was used in construction of a Pr3+ potentiometric electrode. The nano-composite electrode showed better sensitivity, selectivity, response time, response stability and lifetime in comparison with typical carbon paste electrodes. The best performance for nano-composite sensor was obtained with electrode composition of 25% BMT, 25% IL, 45% graphite powder, and 5% MWCNT. The new electrode exhibited a Nernstian response (20.1±0.4 mV per decade) toward Pr3+ ions in the range of 1.0×10-6-1.0×10-2 mol L-1. © 2011 by ESG. Source


Faridbod F.,Tehran University of Medical Sciences | Ganjali M.R.,Tehran University of Medical Sciences | Ganjali M.R.,University of Tehran | Pirali-Hamedani M.,Tehran University of Medical Sciences | And 3 more authors.
International Journal of Electrochemical Science | Year: 2010

Fluorescence studies in acetonitrile solution proved a strong interaction between N'-(1-oxoacenaphthylen-2(1H)-ylidene) furan-2-carbohydrazide (L) with Yb3+ ions in comparison with other lanthanide ions. Thus, L can be used as a suitable ionophore in construction of the Yb3+ potentiometric sensor. To have an electrode with enhanced mechanical resistant in real samples, L was used as a sensing material in new composite carbon paste electrode. The carbon paste were made based on a new nano-composite including multi-wall carbon nanotube (MWCNT), and room temperature ionic liquid, 1-n-butyl-3-methylimidazolium tetrafluoroborate [bmim]BF4. The nano-composite electrode showed better sensitivity, selectivity, response time, response stability and lifetime in comparison with typical carbon paste electrodes. The best performance for nano-composite sensor was obtained with electrode composition of 25% L, 25% [bmim]BF4, 45% graphite powder, and 5% MWCNT. The new electrode exhibited a Nernstian response (19.6±0.3 mV per decade) toward Yb3+ ions in the range of 1.0×10-8-1.0×10-2 mol L-1. © 2010 by ESG. Source

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