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Nel mese di luglio è stato acquisito il 100% del capitale sociale di Pro Farma AG, società farmaceutica svizzera con sede nel cantone di Zug. La transazione, il cui valore (enterprise value) è di CHF 16 milioni, è stata interamente finanziata con la liquidità disponibile. Pro Farma, con un fatturato per il 2016 di circa CHF 10 milioni, commercializza specialità medicinali proprie o in licenza in selezionate aree terapeutiche, sia etiche che di automedicazione. I principali marchi sono Lacdigest (tilactase), Tretinac (isotretinoina) e Urocit (citrato di potassio). Inoltre, la società ha una attività di distribuzione e di servizi di promozione per conto di altre società farmaceutiche. L'acquisizione di Pro Farma rappresenta un'ottima base per le attività operative in Svizzera dove Recordati ha recentemente iniziato a commercializzare direttamente il suo portafoglio prodotti. Inoltre, il prodotto principale Lacdigest contribuisce ulteriormente a potenziare la nostra presenza nell'area della gastroenterologia. Nel mese di luglio è stata anche perfezionata un'alleanza con AP-HP (Assistance Publique - Hopitaux de Paris) per la concessione esclusiva di una licenza globale a Orphan Europe (società del gruppo Recordati) per lo sviluppo e la commercializzazione di un prodotto innovativo per il trattamento di episodi acuti in pazienti affetti dalla malattia delle urine a sciroppo d'acero (MSUD), un grave disturbo metabolico. Nel mese di agosto è stato firmato un accordo di licenza esclusiva con Gedeon Richter per la commercializzazione di cariprazina, un innovativo farmaco antipsicotico atipico in Europa Occidentale, Algeria, Tunisia e Turchia. Nel mese di marzo 2016, EMA (European Medicines Agency) ha iniziato la valutazione della richiesta di autorizzazione all'immissione in commercio in Europa per la cariprazina nel trattamento della schizofrenia. La schizofrenia è un disturbo cronico invalidante che ha una prevalenza globale di circa l'1% con un forte impatto sui pazienti, le loro famiglie e la società in generale. I sintomi appartengono a tre categorie: sintomi positivi (allucinazioni, illusioni, disturbi del pensiero, disturbi dei movimenti), sintomi negativi (perdita di motivazione e comportamento asociale) e sintomi cognitivi (ridotte funzioni esecutive, difficoltà di attenzione e concentrazione, problemi relativi alla memoria di lavoro). Cariprazina è un potente agonista parziale dei recettori D /D della dopamina, con preferenza per il recettore D , e agonista parziale dei recettori 5-HT della serotonina, somministrata oralmente. Sulla base dei risultati ottenuti proponiamo la distribuzione agli azionisti di un dividendo pari a € 0,35, a saldo dell'acconto sul dividendo dell'esercizio 2016 di € 0,35, per ciascuna delle azioni in circolazione alla data di stacco cedola (n. 19), il 24 aprile 2017 (con pagamento il 26 aprile 2017 e record date il 25 aprile 2017), escluse le azioni proprie in portafoglio a quella data. Il dividendo complessivo per azione dell'esercizio 2016 ammonta perciò a € 0,70 per azione (€ 0,60 per azione nel 2015). In merito alla proposta di rinnovo dell'autorizzazione all'acquisto e disposizione di azioni proprie fino all'Assemblea che approverà il bilancio al 31 dicembre 2017, si precisa che tale proposta risponde, in coerenza con gli scorsi esercizi, a molteplici scopi: consentire alla Società di realizzare operazioni quali la vendita, il conferimento e la permuta di azioni proprie per acquisizione di partecipazioni e/o la conclusione di accordi con partner strategici; permettere alla Società di compiere investimenti che abbiano oggetto propri titoli; costituire la provvista necessaria a dare esecuzione a piani di stock option. Il numero massimo di azioni acquistabili, tenuto conto delle azioni proprie di volta in volta già detenute in portafoglio della Società, è 10.000.000 per un potenziale esborso massimo di € 300.000.000, ad un prezzo minimo non inferiore al valore nominale dell'azione Recordati (€ 0,125) e ad un corrispettivo massimo non superiore alla media dei prezzi ufficiali di Borsa delle cinque sedute precedenti l'acquisto, aumentata del 5%. Gli eventuali acquisti verranno effettuati sui mercati regolamentati, in conformità a quanto previsto nell'art. 132 del D. lgs. 58/1998 e nel rispetto e secondo le modalità di cui all'art. 144bis, primo comma, lett.b), del Regolamento Emittenti approvato con delibera CONSOB n.11971/1999 nonché delle prassi di mercato ammesse e riconosciute da CONSOB e fermo quanto previsto nel Regolamento UE n.596/2014 del 16 aprile 2014 e relative disposizioni di attuazione, ove applicabili. Alla data del 28 febbraio 2017 la Società detiene in portafoglio n. 3.195.262 azioni proprie, corrispondenti al 1,53% del capitale sociale. Il Consiglio di Amministrazione ha altresì approvato il progetto di fusione per incorporazione in Recordati S.p.A. della società lussemburghese, interamente controllata, Recordati SA Chemical and Pharmaceutical Company, in un'ottica di razionalizzazione della propria catena di controllo relativa alle società estere. Recordati (Reuters RECI.MI, Bloomberg REC IM), fondata nel 1926, è un gruppo farmaceutico internazionale, quotato alla Borsa Italiana (ISIN IT 0003828271), con circa 4.000 dipendenti, che si dedica alla ricerca, allo sviluppo, alla produzione e alla commercializzazione di prodotti farmaceutici. Ha sede a Milano, e attività operative nei principali paesi europei, in Russia e negli altri paesi del Centro ed Est Europa, in Turchia, in Nord Africa, negli Stati Uniti d'America e in alcuni paesi latino americani. Un'efficiente rete di informatori scientifici del farmaco promuove un'ampia gamma di farmaci innovativi, sia originali sia su licenza, appartenenti a diverse aree terapeutiche compresa un'attività specializzata nelle malattie rare. Recordati si propone come partner di riferimento per l'acquisizione di nuove licenze per i suoi mercati.  Recordati è impegnata nella ricerca e sviluppo di farmaci innovativi per l'area genito-urinaria ed anche di terapie per malattie rare.  I ricavi consolidati nel 2016 sono stati pari a € 1.153,9 milioni, l'utile operativo è stato pari a € 327.4 milioni e l'utile netto è stato pari a € 237.4 milioni. Questa comunicazione contiene valutazioni e ipotesi su fatti futuri ("forward-looking statements" nel significato di cui all'U.S. Private Securities Litigation Reform Act del 1995) che riflettono la migliore stima in base a quanto attualmente noto. Tali valutazioni e ipotesi, tuttavia, dipendono anche da numerosi fattori esterni, fuori dal controllo della società, e da avvenimenti incerti, che sono soggetti a numerosi rischi. I risultati futuri potrebbero differire anche sensibilmente da quanto espresso o deducibile da questa comunicazione. Le citazioni e descrizioni di "specialità etiche Recordati", soggette a prescrizione medica, vengono date solo per informare gli azionisti sull'attività della Società e non hanno alcun intendimento né di promuovere né di consigliare l'uso delle specialità stesse.


Nel mese di luglio è stato acquisito il 100% del capitale sociale di Pro Farma AG, società farmaceutica svizzera con sede nel cantone di Zug. La transazione, il cui valore (enterprise value) è di CHF 16 milioni, è stata interamente finanziata con la liquidità disponibile. Pro Farma, con un fatturato per il 2016 di circa CHF 10 milioni, commercializza specialità medicinali proprie o in licenza in selezionate aree terapeutiche, sia etiche che di automedicazione. I principali marchi sono Lacdigest (tilactase), Tretinac (isotretinoina) e Urocit (citrato di potassio). Inoltre, la società ha una attività di distribuzione e di servizi di promozione per conto di altre società farmaceutiche. L'acquisizione di Pro Farma rappresenta un'ottima base per le attività operative in Svizzera dove Recordati ha recentemente iniziato a commercializzare direttamente il suo portafoglio prodotti. Inoltre, il prodotto principale Lacdigest contribuisce ulteriormente a potenziare la nostra presenza nell'area della gastroenterologia. Nel mese di luglio è stata anche perfezionata un'alleanza con AP-HP (Assistance Publique - Hopitaux de Paris) per la concessione esclusiva di una licenza globale a Orphan Europe (società del gruppo Recordati) per lo sviluppo e la commercializzazione di un prodotto innovativo per il trattamento di episodi acuti in pazienti affetti dalla malattia delle urine a sciroppo d'acero (MSUD), un grave disturbo metabolico. Nel mese di agosto è stato firmato un accordo di licenza esclusiva con Gedeon Richter per la commercializzazione di cariprazina, un innovativo farmaco antipsicotico atipico in Europa Occidentale, Algeria, Tunisia e Turchia. Nel mese di marzo 2016, EMA (European Medicines Agency) ha iniziato la valutazione della richiesta di autorizzazione all'immissione in commercio in Europa per la cariprazina nel trattamento della schizofrenia. La schizofrenia è un disturbo cronico invalidante che ha una prevalenza globale di circa l'1% con un forte impatto sui pazienti, le loro famiglie e la società in generale. I sintomi appartengono a tre categorie: sintomi positivi (allucinazioni, illusioni, disturbi del pensiero, disturbi dei movimenti), sintomi negativi (perdita di motivazione e comportamento asociale) e sintomi cognitivi (ridotte funzioni esecutive, difficoltà di attenzione e concentrazione, problemi relativi alla memoria di lavoro). Cariprazina è un potente agonista parziale dei recettori D /D della dopamina, con preferenza per il recettore D , e agonista parziale dei recettori 5-HT della serotonina, somministrata oralmente. Sulla base dei risultati ottenuti proponiamo la distribuzione agli azionisti di un dividendo pari a € 0,35, a saldo dell'acconto sul dividendo dell'esercizio 2016 di € 0,35, per ciascuna delle azioni in circolazione alla data di stacco cedola (n. 19), il 24 aprile 2017 (con pagamento il 26 aprile 2017 e record date il 25 aprile 2017), escluse le azioni proprie in portafoglio a quella data. Il dividendo complessivo per azione dell'esercizio 2016 ammonta perciò a € 0,70 per azione (€ 0,60 per azione nel 2015). In merito alla proposta di rinnovo dell'autorizzazione all'acquisto e disposizione di azioni proprie fino all'Assemblea che approverà il bilancio al 31 dicembre 2017, si precisa che tale proposta risponde, in coerenza con gli scorsi esercizi, a molteplici scopi: consentire alla Società di realizzare operazioni quali la vendita, il conferimento e la permuta di azioni proprie per acquisizione di partecipazioni e/o la conclusione di accordi con partner strategici; permettere alla Società di compiere investimenti che abbiano oggetto propri titoli; costituire la provvista necessaria a dare esecuzione a piani di stock option. Il numero massimo di azioni acquistabili, tenuto conto delle azioni proprie di volta in volta già detenute in portafoglio della Società, è 10.000.000 per un potenziale esborso massimo di € 300.000.000, ad un prezzo minimo non inferiore al valore nominale dell'azione Recordati (€ 0,125) e ad un corrispettivo massimo non superiore alla media dei prezzi ufficiali di Borsa delle cinque sedute precedenti l'acquisto, aumentata del 5%. Gli eventuali acquisti verranno effettuati sui mercati regolamentati, in conformità a quanto previsto nell'art. 132 del D. lgs. 58/1998 e nel rispetto e secondo le modalità di cui all'art. 144bis, primo comma, lett.b), del Regolamento Emittenti approvato con delibera CONSOB n.11971/1999 nonché delle prassi di mercato ammesse e riconosciute da CONSOB e fermo quanto previsto nel Regolamento UE n.596/2014 del 16 aprile 2014 e relative disposizioni di attuazione, ove applicabili. Alla data del 28 febbraio 2017 la Società detiene in portafoglio n. 3.195.262 azioni proprie, corrispondenti al 1,53% del capitale sociale. Il Consiglio di Amministrazione ha altresì approvato il progetto di fusione per incorporazione in Recordati S.p.A. della società lussemburghese, interamente controllata, Recordati SA Chemical and Pharmaceutical Company, in un'ottica di razionalizzazione della propria catena di controllo relativa alle società estere. Recordati (Reuters RECI.MI, Bloomberg REC IM), fondata nel 1926, è un gruppo farmaceutico internazionale, quotato alla Borsa Italiana (ISIN IT 0003828271), con circa 4.000 dipendenti, che si dedica alla ricerca, allo sviluppo, alla produzione e alla commercializzazione di prodotti farmaceutici. Ha sede a Milano, e attività operative nei principali paesi europei, in Russia e negli altri paesi del Centro ed Est Europa, in Turchia, in Nord Africa, negli Stati Uniti d'America e in alcuni paesi latino americani. Un'efficiente rete di informatori scientifici del farmaco promuove un'ampia gamma di farmaci innovativi, sia originali sia su licenza, appartenenti a diverse aree terapeutiche compresa un'attività specializzata nelle malattie rare. Recordati si propone come partner di riferimento per l'acquisizione di nuove licenze per i suoi mercati.  Recordati è impegnata nella ricerca e sviluppo di farmaci innovativi per l'area genito-urinaria ed anche di terapie per malattie rare.  I ricavi consolidati nel 2016 sono stati pari a € 1.153,9 milioni, l'utile operativo è stato pari a € 327.4 milioni e l'utile netto è stato pari a € 237.4 milioni. Questa comunicazione contiene valutazioni e ipotesi su fatti futuri ("forward-looking statements" nel significato di cui all'U.S. Private Securities Litigation Reform Act del 1995) che riflettono la migliore stima in base a quanto attualmente noto. Tali valutazioni e ipotesi, tuttavia, dipendono anche da numerosi fattori esterni, fuori dal controllo della società, e da avvenimenti incerti, che sono soggetti a numerosi rischi. I risultati futuri potrebbero differire anche sensibilmente da quanto espresso o deducibile da questa comunicazione. Le citazioni e descrizioni di "specialità etiche Recordati", soggette a prescrizione medica, vengono date solo per informare gli azionisti sull'attività della Società e non hanno alcun intendimento né di promuovere né di consigliare l'uso delle specialità stesse.


Nel mese di luglio è stato acquisito il 100% del capitale sociale di Pro Farma AG, società farmaceutica svizzera con sede nel cantone di Zug. La transazione, il cui valore (enterprise value) è di CHF 16 milioni, è stata interamente finanziata con la liquidità disponibile. Pro Farma, con un fatturato per il 2016 di circa CHF 10 milioni, commercializza specialità medicinali proprie o in licenza in selezionate aree terapeutiche, sia etiche che di automedicazione. I principali marchi sono Lacdigest (tilactase), Tretinac (isotretinoina) e Urocit (citrato di potassio). Inoltre, la società ha una attività di distribuzione e di servizi di promozione per conto di altre società farmaceutiche. L'acquisizione di Pro Farma rappresenta un'ottima base per le attività operative in Svizzera dove Recordati ha recentemente iniziato a commercializzare direttamente il suo portafoglio prodotti. Inoltre, il prodotto principale Lacdigest contribuisce ulteriormente a potenziare la nostra presenza nell'area della gastroenterologia. Nel mese di luglio è stata anche perfezionata un'alleanza con AP-HP (Assistance Publique - Hopitaux de Paris) per la concessione esclusiva di una licenza globale a Orphan Europe (società del gruppo Recordati) per lo sviluppo e la commercializzazione di un prodotto innovativo per il trattamento di episodi acuti in pazienti affetti dalla malattia delle urine a sciroppo d'acero (MSUD), un grave disturbo metabolico. Nel mese di agosto è stato firmato un accordo di licenza esclusiva con Gedeon Richter per la commercializzazione di cariprazina, un innovativo farmaco antipsicotico atipico in Europa Occidentale, Algeria, Tunisia e Turchia. Nel mese di marzo 2016, EMA (European Medicines Agency) ha iniziato la valutazione della richiesta di autorizzazione all'immissione in commercio in Europa per la cariprazina nel trattamento della schizofrenia. La schizofrenia è un disturbo cronico invalidante che ha una prevalenza globale di circa l'1% con un forte impatto sui pazienti, le loro famiglie e la società in generale. I sintomi appartengono a tre categorie: sintomi positivi (allucinazioni, illusioni, disturbi del pensiero, disturbi dei movimenti), sintomi negativi (perdita di motivazione e comportamento asociale) e sintomi cognitivi (ridotte funzioni esecutive, difficoltà di attenzione e concentrazione, problemi relativi alla memoria di lavoro). Cariprazina è un potente agonista parziale dei recettori D /D della dopamina, con preferenza per il recettore D , e agonista parziale dei recettori 5-HT della serotonina, somministrata oralmente. Sulla base dei risultati ottenuti proponiamo la distribuzione agli azionisti di un dividendo pari a € 0,35, a saldo dell'acconto sul dividendo dell'esercizio 2016 di € 0,35, per ciascuna delle azioni in circolazione alla data di stacco cedola (n. 19), il 24 aprile 2017 (con pagamento il 26 aprile 2017 e record date il 25 aprile 2017), escluse le azioni proprie in portafoglio a quella data. Il dividendo complessivo per azione dell'esercizio 2016 ammonta perciò a € 0,70 per azione (€ 0,60 per azione nel 2015). In merito alla proposta di rinnovo dell'autorizzazione all'acquisto e disposizione di azioni proprie fino all'Assemblea che approverà il bilancio al 31 dicembre 2017, si precisa che tale proposta risponde, in coerenza con gli scorsi esercizi, a molteplici scopi: consentire alla Società di realizzare operazioni quali la vendita, il conferimento e la permuta di azioni proprie per acquisizione di partecipazioni e/o la conclusione di accordi con partner strategici; permettere alla Società di compiere investimenti che abbiano oggetto propri titoli; costituire la provvista necessaria a dare esecuzione a piani di stock option. Il numero massimo di azioni acquistabili, tenuto conto delle azioni proprie di volta in volta già detenute in portafoglio della Società, è 10.000.000 per un potenziale esborso massimo di € 300.000.000, ad un prezzo minimo non inferiore al valore nominale dell'azione Recordati (€ 0,125) e ad un corrispettivo massimo non superiore alla media dei prezzi ufficiali di Borsa delle cinque sedute precedenti l'acquisto, aumentata del 5%. Gli eventuali acquisti verranno effettuati sui mercati regolamentati, in conformità a quanto previsto nell'art. 132 del D. lgs. 58/1998 e nel rispetto e secondo le modalità di cui all'art. 144bis, primo comma, lett.b), del Regolamento Emittenti approvato con delibera CONSOB n.11971/1999 nonché delle prassi di mercato ammesse e riconosciute da CONSOB e fermo quanto previsto nel Regolamento UE n.596/2014 del 16 aprile 2014 e relative disposizioni di attuazione, ove applicabili. Alla data del 28 febbraio 2017 la Società detiene in portafoglio n. 3.195.262 azioni proprie, corrispondenti al 1,53% del capitale sociale. Il Consiglio di Amministrazione ha altresì approvato il progetto di fusione per incorporazione in Recordati S.p.A. della società lussemburghese, interamente controllata, Recordati SA Chemical and Pharmaceutical Company, in un'ottica di razionalizzazione della propria catena di controllo relativa alle società estere. Recordati (Reuters RECI.MI, Bloomberg REC IM), fondata nel 1926, è un gruppo farmaceutico internazionale, quotato alla Borsa Italiana (ISIN IT 0003828271), con circa 4.000 dipendenti, che si dedica alla ricerca, allo sviluppo, alla produzione e alla commercializzazione di prodotti farmaceutici. Ha sede a Milano, e attività operative nei principali paesi europei, in Russia e negli altri paesi del Centro ed Est Europa, in Turchia, in Nord Africa, negli Stati Uniti d'America e in alcuni paesi latino americani. Un'efficiente rete di informatori scientifici del farmaco promuove un'ampia gamma di farmaci innovativi, sia originali sia su licenza, appartenenti a diverse aree terapeutiche compresa un'attività specializzata nelle malattie rare. Recordati si propone come partner di riferimento per l'acquisizione di nuove licenze per i suoi mercati.  Recordati è impegnata nella ricerca e sviluppo di farmaci innovativi per l'area genito-urinaria ed anche di terapie per malattie rare.  I ricavi consolidati nel 2016 sono stati pari a € 1.153,9 milioni, l'utile operativo è stato pari a € 327.4 milioni e l'utile netto è stato pari a € 237.4 milioni. Questa comunicazione contiene valutazioni e ipotesi su fatti futuri ("forward-looking statements" nel significato di cui all'U.S. Private Securities Litigation Reform Act del 1995) che riflettono la migliore stima in base a quanto attualmente noto. Tali valutazioni e ipotesi, tuttavia, dipendono anche da numerosi fattori esterni, fuori dal controllo della società, e da avvenimenti incerti, che sono soggetti a numerosi rischi. I risultati futuri potrebbero differire anche sensibilmente da quanto espresso o deducibile da questa comunicazione. Le citazioni e descrizioni di "specialità etiche Recordati", soggette a prescrizione medica, vengono date solo per informare gli azionisti sull'attività della Società e non hanno alcun intendimento né di promuovere né di consigliare l'uso delle specialità stesse.


SAN DIEGO--(BUSINESS WIRE)--La Jolla Pharmaceutical Company (Nasdaq: LJPC) (La Jolla), today announced positive top-line results from the ATHOS-3 (Angiotensin II for the Treatment of High-Output Shock) Phase 3 study of LJPC-501 (angiotensin II) in patients with catecholamine resistant hypotension (CRH). The analysis of the primary efficacy endpoint, defined as the percentage of patients achieving a pre-specified target blood pressure response, was highly statistically significant: 23% of the 158 placebo-treated patients had a blood pressure response compared to 70% of the 163 LJPC-501-treated patients (p<0.00001). In addition, a trend toward longer survival was observed: 22% reduction in mortality risk through day 28 [hazard ratio=0.78 (0.57-1.07), p=0.12] for LJPC-501-treated patients. Throughout the study, safety outcomes were followed by an independent Data Safety Monitoring Board (DSMB). The DSMB recommended that the study continue as originally planned. In this critically ill patient population: 92% of placebo-treated patients compared to 87% of LJPC-501-treated patients experienced at least one adverse event, and 22% of placebo-treated patients compared to 14% of LJPC-501-treated patients discontinued treatment due to an adverse event. In collaboration with the investigators, La Jolla plans to present and publish detailed results from the ATHOS-3 study later this year. ATHOS-3 was conducted under a Special Protocol Assessment with the U.S. Food and Drug Administration (FDA), in which the company and FDA agreed on the study design, study endpoints and study analyses. “ These study results support that angiotensin II, a molecule first synthesized by Dr. Irvine Page at the Cleveland Clinic, improves outcomes in distributive shock patients requiring high-dose catecholamines. Given the high mortality from this condition, it is important to offer physicians another potential treatment option,” said Daniel Sessler, M.D., the Michael Cudahy Professor and Chair of the Department of Outcomes Research at Cleveland Clinic. “ We are grateful to the patients, their families and the dedicated medical teams who contributed to this successful study,” said George F. Tidmarsh, M.D., Ph.D., president and chief executive officer of La Jolla. “ We also are very appreciative of the FDA’s advice and contributions in the development of LJPC-501 and look forward to meeting with the FDA to discuss our NDA submission planned for the second half of this year.” Conference Call at 8:30 a.m. EST on Monday, February 27, 2017 La Jolla will host a conference call and webcast at 8:30 a.m. EST (5:30 a.m. PST) on Monday, February 27, 2017. The conference call can be accessed by dialing 877-359-9508 for domestic callers and 224-357-2393 for international callers. Please provide the operator with the passcode 78311826 to join the conference call or click here for the webcast. A slide presentation accompanying today’s press release and the conference call may also be found on La Jolla’s website at www.ljpc.com under the investor relations section. An archive of the conference call and webcast will be available on La Jolla’s website for 30 days following the call. The ATHOS-3 study (https://www.ncbi.nlm.nih.gov/pubmed/28215131) was a multicenter, randomized, double-blind, placebo-controlled, Phase 3 clinical study of LJPC-501 in patients with catecholamine resistant hypotension. A total of 344 patients were randomized across nine countries, 321 of whom received study treatment and are included in the primary analysis. Patients were randomized 1:1 to receive either LJPC-501 or placebo on a background of standard-of-care vasopressors selected by the investigators. Randomized patients received their assigned treatment via continuous intravenous infusion. The primary efficacy endpoint was the percentage of patients with a mean arterial pressure (MAP) ≥ 75 mmHg or a 10 mmHg increase from baseline MAP at 3 hours following the initiation of study treatment without an increase in standard-of-care vasopressors. The study was conducted under a Special Protocol Assessment (SPA) agreed to with the U.S. Food and Drug Administration (FDA) in 2015. The SPA stipulates that a study of this size and design could provide sufficient safety and efficacy signals and an adequate evaluation of the risk/benefit to the patients to support FDA review and consideration for marketing approval. LJPC-501 is La Jolla’s proprietary formulation of synthetic human angiotensin II. Angiotensin II, the major bioactive component of the renin-angiotensin system, serves as one of the body’s central regulators of blood pressure. LJPC-501 is being developed for the treatment of patients with catecholamine resistant hypotension (CRH). LJPC-501 is the first synthetic human angiotensin II product candidate to be tested in a Phase 3 study. Catecholamine resistant hypotension (CRH) is a life-threatening syndrome in patients with distributive shock (dangerously low blood pressure with adequate cardiac function) who cannot achieve target mean arterial pressure (MAP) despite adequate fluid resuscitation and treatment with currently available vasopressors (catecholamines and/or vasopressin). There are approximately 500,000 distributive shock cases in the United States per year, an estimated 200,000 of which develop CRH. More than 50% of CRH patients die within 30 days. La Jolla Pharmaceutical Company is a biopharmaceutical company focused on the discovery, development and commercialization of innovative therapies intended to significantly improve outcomes in patients suffering from life-threatening diseases. The company has several product candidates in development. LJPC-501 is La Jolla’s proprietary formulation of synthetic human angiotensin II for the potential treatment of catecholamine resistant hypotension. LJPC-401 is La Jolla’s proprietary formulation of synthetic human hepcidin for the potential treatment of conditions characterized by iron overload, such as hereditary hemochromatosis, beta thalassemia, sickle cell disease and myelodysplastic syndrome. LJPC-30S is La Jolla’s next-generation gentamicin derivative program that is focused on the potential treatment of serious bacterial infections as well as rare genetic disorders, such as cystic fibrosis and Duchenne muscular dystrophy. For more information on La Jolla, please visit www.ljpc.com. This press release contains forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements relate to future events or the company’s future results of operations. These statements are only predictions or statements of current expectations and involve known and unknown risks, uncertainties and other factors, that may cause actual results to be materially different from those anticipated by the forward-looking statements. The company cautions readers not to place undue reliance on any such forward-looking statements, which speak only as of the date they were made. Certain of these risks, uncertainties, and other factors are described in greater detail in the company’s filings with the U.S. Securities and Exchange Commission (SEC), all of which are available free of charge on the SEC’s web site www.sec.gov. These risks include, but are not limited to, risks relating to: the timing of the NDA submission for LJPC-501 and prospects for approval of the NDA; risks that the full data set from the ATHOS-3 study will not be consistent with the top-line results of the study; risks relating to the scope of product labels (if approved) and potential market sizes, as well as the broader commercial opportunity; the anticipated timing for regulatory actions; the success of future development activities; potential indications for which the company’s product candidates may be developed; and the expected duration over which the company’s cash balances will fund its operations. Subsequent written and oral forward-looking statements attributable to the company or to persons acting on its behalf are expressly qualified in their entirety by the cautionary statements set forth in the company’s reports filed with the SEC. The company expressly disclaims any intent to update any forward-looking statements.


News Article | November 29, 2016
Site: www.newsmaker.com.au

Fibrosis refers to a phenomenon of development of excessive connective tissue as a result of some injury or some disease. It results in formation of a layer around an organ in a repetitive manner which results in improper working of that organ. It often leads to scarring. Fibrosis occurs in various organs and is named according to its location. For instance, fibrosis in lungs is known as pulmonary fibrosis, whereas, fibrosis in liver is known as cirrhosis. Kidney fibrosis may be caused due to disease in kidney. It may be any stage from chronic kidney disease (CKD) to end-stage renal disease (ESRD). In this condition, kidneys stop working and gradually require transplantation. Various medications that are available in the market for treatment of kidney fibrosis are Renin inhibitors, Vasopeptidase inhibitors, Angiotensin II receptor blockers (ARBs), Angiotensin-converting enzyme (ACE) inhibitors and Pirfenidones. Increasing prevalence of kidney diseases and no other alternative treatment available is driving the market for kidney fibrosis treatment. North America, followed by the Europe, dominates the global market for kidney fibrosis due to large number of aging population and better healthcare facilities available in the region. In addition, there is high prevalence of kidney diseases in the region. According to The Centers for Disease Control and Prevention (CDC), a public health institute in 2014, in the U.S., it is estimated that more than 20 million people are suffering from chronic kidney disease. Asia is expected to show high growth rate in the next few years in global kidney fibrosis treatment market. China and India are expected to be the fastest kidney fibrosis market in Asia region. Some of the key driving forces for kidney fibrosis market in emerging countries are increasing R&D investment, large pool of patients, rising government funding and growing level of awareness. Diseases such as obesity accelerate the incidence of kidney fibrosis. In addition, habits such smoking also adds to increment in incidence of kidney fibrosis. Increasing patient pool, rising awareness about treatment of kidney diseases and government funding are some of the key factors driving the kidney fibrosis market. In addition, introduction of safer and effective therapeutics for the treatment of kidney fibrosis is driving the market. However, high cost involved and no success for all the cases is restraining the kidney fibrosis market. Request TOC (desk of content material), Figures and Tables of the report: http://www.persistencemarketresearch.com/toc/3102 Introduction of the concept of personalized medicines, mono-therapeutic approaches or combination of therapies are expected to offer good opportunities for kidney fibrosis market. In addition, introduction statins for, which are related to lowering of lipid content, thus expected to be an efficient treatment for kidney scarring. Growing demographics and economies in the developing countries such as India and China in Asia and other countries in South East Asia, Latin America and Middle East are expected to offer high growth in kidney fibrosis treatment market. One of the major trends that have been observed in kidney fibrosis treatment market includes various pharmaceutical and biotechnology companies involved in R&D of some novel medications for the treatment of kidney fibrosis. Some of the key companies dealing in kidney fibrosis treatment market are F. Hoffmann-La Roche Ltd., Pfizer, Inc, La Jolla Pharmaceutical Company, Merck & Co., InterMune, Inc. and Galectin Therapeutics, Inc. Other companies dealing the kidney fibrosis treatment market which have significant presence are Genzyme Corporation, ProMetic Life Sciences Inc. and BioLineRx, Ltd.


News Article | November 28, 2016
Site: www.newsmaker.com.au

North America, followed by the Europe, dominates the global market for kidney fibrosis due to large number of aging population and better healthcare facilities available in the region. In addition, there is high prevalence of kidney diseases in the region. According to The Centers for Disease Control and Prevention (CDC), a public health institute in 2014, in the U.S., it is estimated that more than 20 million people are suffering from chronic kidney disease. Asia is expected to show high growth rate in the next few years in global kidney fibrosis treatment market. China and India are expected to be the fastest kidney fibrosis market in Asia region. Some of the key driving forces for kidney fibrosis market in emerging countries are increasing R&D investment, large pool of patients, rising government funding and growing level of awareness. Diseases such as obesity accelerate the incidence of kidney fibrosis. In addition, habits such smoking also adds to increment in incidence of kidney fibrosis. Increasing patient pool, rising awareness about treatment of kidney diseases and government funding are some of the key factors driving the kidney fibrosis market. In addition, introduction of safer and effective therapeutics for the treatment of kidney fibrosis is driving the market. However, high cost involved and no success for all the cases is restraining the kidney fibrosis market. Request TOC (desk of content material), Figures and Tables of the report: http://www.persistencemarketresearch.com/toc/3102 Introduction of the concept of personalized medicines, mono-therapeutic approaches or combination of therapies are expected to offer good opportunities for kidney fibrosis market. In addition, introduction statins for, which are related to lowering of lipid content, thus expected to be an efficient treatment for kidney scarring. Growing demographics and economies in the developing countries such as India and China in Asia and other countries in South East Asia, Latin America and Middle East are expected to offer high growth in kidney fibrosis treatment market. One of the major trends that have been observed in kidney fibrosis treatment market includes various pharmaceutical and biotechnology companies involved in R&D of some novel medications for the treatment of kidney fibrosis. Some of the key companies dealing in kidney fibrosis treatment market are F. Hoffmann-La Roche Ltd., Pfizer, Inc, La Jolla Pharmaceutical Company, Merck & Co., InterMune, Inc. and Galectin Therapeutics, Inc. Other companies dealing the kidney fibrosis treatment market which have significant presence are Genzyme Corporation, ProMetic Life Sciences Inc. and BioLineRx, Ltd.


Easton Pharmaceuticals Provides Other Updates On Medical Marijuana Initiatives And Confirms It Has Received And Is Reviewing A Preliminary Proposal From A Major Multi-National Pharmaceutical Company While Entering Into Contract Phase With A Second Large Pharmaceutical Company For Other Licensed Products and Territories TORONTO, ON--(Marketwired - Nov 15, 2016) - Easton Pharmaceuticals Inc. ( : EAPH) announces that all required technical documents have been received from Biolyse Pharma Corporation of St. Catharines, Ontario, Canada, for cancer drug Paclitaxel and are now ready for submission for fast track approval with the Mexican Ministry Of Health. Easton Pharmaceuticals and partner BMV Medica have secured the rights from Biolyse Pharma to distribute the generic cancer drugs Docetaxel and Paclitaxel for Mexico and Latin America. The regulatory landscape and requirements have recently changed regarding the validation and sourcing of raw materials or Active Pharmaceutical Ingredients (API) received for incorporation into the final manufacturing process from overseas suppliers, which has caused delays in the filing process. Easton / BMV through Ackerman Pharma in Mexico will file a conditional submission for approval, enabling Biolyse time to receive the final Good Manufacturing Practices (GMP) approval for its raw material, expected within 3 to 6 months, paralleling the expected timeline for Mexican government approval. Easton / BMV / Ackerman are negotiating and expect a Purchase Order immediately upon receipt of Mexican Marketing authorization. Now that the dossier is near completion, only awaiting the Biolyse GMP certificate and Certificate of Pharmaceutical Product (CPP), documents which need consularization, which is a two-to-three week process, Ackerman Pharma has provided a positive update on the regulatory filing with the Mexican Ministry Of Health for approval of the generic cancer drug Paclitaxel from St. Catharines, Ontario-based Biolyse Pharma Corporation. DEFI Latina, a government authorized third-party reviewer, will then be filing for a "fast-track" approval, considerably shortening the approval time from several years to 3 to 6 months, similar to the previously announced VagiSan (VS-Sense) approval. The majority of expected sales in Mexico will be to the Mexican government hospitals and institutions. Canadian-manufactured pharmaceuticals qualify for the national tender program in Mexico, providing a major advantage over other non-NAFTA manufacturers. The paclitaxel and docetaxel market in Mexico is by itself worth tens of millions of dollars annually. Easton / BMV expect to be able to garner 20% of this market within a year of launch, growing to 30% within three years. The total generic cancer drug market in Mexico represents hundreds of millions of dollars. Ackerman Pharma is a niche pharmaceutical company operating in Mexico, holder of an Establishment License in Mexico, and also active in Sales & Marketing of Diagnostic Devices and Hospital-based injectable drugs. Ackerman currently holds five product Marketing Authorizations in Mexico. In other Latin American countries, BMV / Easton expect to sell in aggregate an equal amount of Biolyse's cancer drugs as in Mexico where some of these other countries have a more streamlined regulatory approval process, allowing BMV to begin selling almost immediately pending distribution arrangements with local companies which Easton has initiated and are currently in discussions with. In these other Latin American markets, the buying of cancer drugs mimics the Mexican model, in that government agencies allow for tender bids to meet their forecast annual supply. Biolyse Pharma markets "Paclitaxel" in Canada and other countries around the world and currently has an overwhelming majority of the Canadian market. Biolyse has been a factor in substantially bringing down the price for "Paclitaxel" in Canada from around $5,000/vial to less than a $100/vial a few years ago. Both "Paclitaxel" and "Docetaxel" are generic drugs and are amongst the most commonly prescribed for several of the most common cancers including breast, lung and ovarian cancers. In addition, "Docetaxel" is extremely difficult to manufacture with only a limited number of companies worldwide possessing the knowhow and facilities to manufacture these and other cancer drugs. As previously stated, the securing of the distribution agreement by BMV for these drugs is another major achievement for BMV/Easton. A 20% share of the Mexican and other Latin American markets could represent tens of millions of dollars in revenues, as overall pharmaceutical sales in Latin America are growing at several times the rate compared to Canada and the US (12-15 % vs 2-3%). The cancer drugs industry is considered a high value business segment to be part of as cancer drugs are expected to surpass cardiovascular drugs as the biggest selling drugs in the world. Every major government body around the world has indicated that cancer will continue to impact more and more people and lives around the world especially in countries possessing an aging population. The Cancer drugs distribution agreement and investment by Easton in BMV builds on the previously announced agreement with Easton and BMV securing the exclusive rights to market and sell CommonSense Ltd's VS-Sense women's diagnostic products for Latin America, geared towards its several hundred million female population where 1 in 3 women will at some point require the use of the test, and currently being sold in the US in CVS and Walgreen's drug stores in the US, and Shoppers Drug Mart stores in Canada, and by Bayer in Europe. Medical Marijuana News Updates Easton Pharmaceuticals has initiated discussions with 2 medical marijuana companies in Canada who currently hold letters to build and are in the late stages under the new ACMPR system which has replaced the older MMPR system. Easton has prepared and is ready to forward a formal acquisition proposal to one and possibly both of these companies as a result of the anticipated legalization of medical marijuana in Canada sometime in the spring of 2017. No names can be disclosed until licensing has been granted, however a much more comprehensive update is pending approval. Other News In other news, as previously announced, Easton continues to confirm it has received and is extensively reviewing a preliminary proposal from a major multi-national pharmaceutical company for its regulatory approved, patented VagiSan (known as VS-Sense) woman's diagnostic test Bacterial Vaginosis for the countries Mexico and Ecuador. In addition, Easton Pharmaceuticals continues to confirm it has entered the contract phase with a second large Pharmaceutical company towards distribution of other Easton licensed products and territories. About Biolyse Pharma Biolyse Pharma Currently maintains a 130,000 sq. ft. facility Licensed aseptic GMP facility, as well as GLP analytical laboratories, Research and Development Facilities, Large scale extraction, purification facility, and possesses Multidisciplinary teams of various scientific expertise. Biolyse Pharma Corp. is a research driven, fully integrated pharmaceutical company headquartered in St. Catherine, Ontario, Canada dedicated to the manufacturing, marketing, and distribution of anti-cancer drugs. About Easton Pharmaceuticals Easton Pharmaceuticals is a diversified specialty pharmaceutical company involved in various pharmaceutical sectors and other growing industries. The Company previously developed and owned an FDA-approved wound-healing medical device and currently owns topically delivered drugs to treat cancer and other therapeutic products to treat various conditions that are all in various stages of development and approval. Easton has partnered with BMV Medica and together own the exclusive distribution rights in Mexico and Latin America for patented women's diagnostic products and two generic cancer drugs. Easton has made additional investments in the medical marijuana industry through AMFIL Technologies, a company involved in medical marijuana and other industries as well as advancing funds towards another Canadian medical marijuana initiative who has received a letter to build under the MMPR system in Canada. The company's gel formulation is thought to be an innovative and unique transdermal delivery system that can in the future be adaptable in the delivery of other drugs and Cannabidiol extracts. Safe Harbor This news release may contain forward-looking statements or expressions within the meaning of the Private Securities Litigation Reform Act of 1995 (The "Act"). In particular, when certain words or phrases such as "hope," "positive," "anticipate," "pleased," "plan," "confident that," "believe," "expect," "possible" or "intent to" and similar conditional expressions are expressed, they are intended to identify forward-looking statements within the meaning of the Act and are subject to the safe harbor created by the Act. Such statements are subject to certain risks and uncertainties and actual results could differ materially from those expressed in any of the forward-looking statements. Any investment made into Easton Pharmaceuticals would be classified as speculative and may contain risks. Such risks and uncertainties include, but are not limited to, market conditions, general acceptance of the company's products and technologies, competitive factors, the ability to successfully complete additional or adequate financing, government approvals or changes to proposed laws and other risks and uncertainties further stated in the company's financial reports and filings.


SAN DIEGO--(BUSINESS WIRE)--La Jolla Pharmaceutical Company (NASDAQ: LJPC) (the Company or La Jolla), a leader in the development of innovative therapies intended to significantly improve outcomes in patients suffering from life-threatening diseases, today reported fourth quarter and full year 2016 financial results and highlighted 2016 corporate progress. “2016 was a productive year for La Jolla, highlighted by the completion of enrollment of our ATHOS 3 Phase 3 trial of LJPC-501 and encouraging results from our Phase 1 trial of LJPC-401,” said George Tidmarsh, M.D., Ph.D., La Jolla’s President and Chief Executive Officer. “We look forward to an exciting 2017, with the expected reporting of top-line results from our ATHOS 3 Phase 3 trial of LJPC-501 in the first quarter of 2017 and the initiation of our pivotal trial for LJPC-401 in mid-2017.” As of December 31, 2016, La Jolla had $65.7 million in cash and cash equivalents, compared to $126.5 million as of December 31, 2015. Based on current operating plans and projections, La Jolla believes that its current cash and cash equivalents are sufficient to fund operations into 2018. La Jolla’s net cash used for operating activities for the three and twelve months ended December 31, 2016 was $18.6 million and $58.7 million, respectively, compared to net cash used for operating activities of $8.5 million and $25.2 million, respectively, for the same periods in 2015. La Jolla’s net loss for the three and twelve months ended December 31, 2016 was $24.9 million and $78.2 million, or $1.44 per share and $4.54 per share, respectively, compared to a net loss of $11.8 million and $41.9 million, or $0.69 per share and $2.68 per share, respectively, for the same periods in 2015. During the three and twelve months ended December 31, 2016, La Jolla recognized contract revenue of approximately $0.1 million and $0.6 million, respectively, compared to contract revenue of $0.4 million and $1.1 million, respectively, for the same periods in 2015. The net loss for the three and twelve months ended December 31, 2016 includes non-cash, share-based compensation expense of $3.6 million and $14.5 million, respectively, compared to non-cash, share-based compensation expense of $2.7 million and $13.1 million, respectively, for the same periods in 2015. The increases in net cash used for operating activities and net loss in 2016 as compared to 2015 were primarily due to increased development costs associated with LJPC-501 and LJPC-401. La Jolla Pharmaceutical Company is a biopharmaceutical company focused on the discovery, development and commercialization of innovative therapies intended to significantly improve outcomes in patients suffering from life-threatening diseases. The Company has several product candidates in development. LJPC-501 is La Jolla’s proprietary formulation of angiotensin II for the potential treatment of catecholamine-resistant hypotension. LJPC-401 is La Jolla’s novel formulation of synthetic human hepcidin for the potential treatment of conditions characterized by iron overload, such as hereditary hemochromatosis, beta thalassemia, sickle cell disease and myelodysplastic syndrome. LJPC-30S is La Jolla’s next-generation gentamicin derivative program that is focused on therapeutics for the potential treatment of serious bacterial infections as well as rare genetic disorders, such as cystic fibrosis and Duchenne muscular dystrophy. For more information on La Jolla, please visit www.ljpc.com. This document contains forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements relate to future events or the Company’s future results of operations. These statements are only predictions and involve known and unknown risks, uncertainties and other factors, which may cause actual results to be materially different from these forward-looking statements. The Company cautions readers not to place undue reliance on any such forward-looking statements, which speak only as of the date they were made. Certain of these risks, uncertainties, and other factors are described in greater detail in the Company’s filings with the U.S. Securities and Exchange Commission (SEC), all of which are available free of charge on the SEC’s website www.sec.gov. These risks include, but are not limited to, risks relating to: the timing for commencement of clinical studies, the anticipated timing for completion of such studies, the anticipated timing for the Company’s filing of new drug applications or similar filings for regulatory approval, and the anticipated timing for regulatory actions; the success of current and future development activities; potential indications for which the Company’s product candidates may be developed; and the expected duration over which the Company’s cash balances will fund its operations. Subsequent written and oral forward-looking statements attributable to the Company or to persons acting on its behalf are expressly qualified in their entirety by the cautionary statements set forth in the Company's reports filed with the SEC. The Company expressly disclaims any intent to update any forward-looking statements.


News Article | December 13, 2016
Site: marketersmedia.com

— The report provides comprehensive information on the therapeutics under development for Hemochromatosis, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in therapeutic development for Hemochromatosis and features dormant and discontinued projects. The report helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. Complete report on Hemochromatosis - Pipeline Review, H2 2016 addition with 17 market data tables and 13 figures, spread across 42 pages is available at http://www.reportsnreports.com/reports/781966-hemochromatosis-pipeline-review-h2-2016.html This report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Directs proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, Investor presentations and featured press releases from company/university sites and industry-specific third party sources. Drug profiles featured in the report undergoes periodic review following a stringent set of processes to ensure that all the profiles are updated with the latest set of information. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis Companies Discussed /Mentioned in this Research: Ionis Pharmaceuticals Inc, La Jolla Pharmaceutical Company, Protagonist Therapeutics Inc, Inquire before buying http://www.reportsnreports.com/contacts/inquirybeforebuy.aspx?name=781966 premium report price at US$2000 for a single user PDF license). Scope • The report provides a snapshot of the global therapeutic landscape of Hemochromatosis • The report reviews pipeline therapeutics for Hemochromatosis by companies and universities/research institutes based on information derived from company and industry-specific sources • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities • The report reviews key players involved Hemochromatosis therapeutics and enlists all their major and minor projects • The report assesses Hemochromatosis therapeutics based on drug target, mechanism of action (MoA), route of administration (RoA) and molecule type • The report summarizes all the dormant and discontinued pipeline projects • The report reviews latest news related to pipeline therapeutics for Hemochromatosis Reasons to buy • Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage • Identify and understand important and diverse types of therapeutics under development for Hemochromatosis • Identify potential new clients or partners in the target demographic • Develop strategic initiatives by understanding the focus areas of leading companies • Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics • Devise corrective measures for pipeline projects by understanding Hemochromatosis pipeline depth and focus of Indication therapeutics • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope • Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline For more information, please visit http://www.reportsnreports.com/reports/781966-hemochromatosis-pipeline-review-h2-2016.html


Mr. Yordon's role has expanded to oversee the operations of the company BUFFALO, New York, March 1, 2017 /PRNewswire/ -- Athenex, Inc. announced today the promotion of Jeffrey M. Yordon to the position of Chief Operating Officer (COO) for the company effective upon Board approval.  Previously Mr. Yordon was the President of the Athenex Pharmaceutical Division (APD), which was focused on commercializing all of Athenex's products and intellectual property. Mr. Yordon has had a long, distinguished career in the pharmaceutical industry with over 47 years of experience.  Previous to joining Athenex, he was the Founder, Chairman of the Board and CEO of Sagent Pharmaceuticals which was recently sold to Nichi-Iko Pharmaceutical Company.  Mr. Yordon was one of the founders of American Pharmaceutical Partners and served as President and COO of the company which was eventually purchased by Fresenius Kobi.  Mr. Yordon also previously held senior management positions at YorPharm, LyphoMed, Faulding Pharmaceuticals and Gensia Laboratories.  "I am looking forward to working with the Athenex management team with a view to achieving key milestones and executing on our growth plan," stated Mr. Yordon. Founded in 2003, Athenex, Inc. is a global clinical stage biopharmaceutical company dedicated to becoming a leader in the discovery and development of next generation drugs for the treatment of cancer. Athenex is organized around three platforms including an Oncology Innovation Platform, a Commercial Platform and an Global Supply Chain Platform. Our Oncology Innovation Platform generates clinical candidates through an extensive understanding of kinases, including novel binding sites, human absorption biology and through the application of our proprietary research and selection processes in the lab. Our current clinical pipeline is derived from two different platform technologies we call Orascovery and Src Kinase Inhibition. The Orascovery platform is based on the novel oral P-glycoprotein pump inhibitor molecule HM30181A, through which we are able to facilitate oral absorption of traditional cytotoxics, which we believe may offer improved patient tolerability and efficacy as compared to IV administration of the same cytotoxics. The Src Kinase Inhibition platform refers to novel small molecule compounds that have multiple mechanisms of action, including the inhibition of the activity of Src Kinase and the inhibition of tubulin polymerization during cell division. We believe the combination of these mechanisms of action provide a broader range of anti-cancer activity as compared to either mechanism of action alone.. Athenex's employees worldwide are dedicated to improving the lives of cancer patients by creating more active and tolerable treatments. Athenex has offices in Buffalo and Clarence, New York, Cranford, New Jersey, Houston, Texas, Chicago, Illinois, Hong Kong, Taipei Taiwan, and multiple locations in Chongqing, China. For more information about Athenex's portfolio of proprietary products and clinical studies, please visit Athenex.com.

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