Stefan-van Staden R.-I.,Romanian National Institute for Research for Electrochemistry and Condensed Matter |
Nejem R.M.,University of Palestine |
van Staden J.F.,Romanian National Institute for Research for Electrochemistry and Condensed Matter |
Aboul-Enein H.Y.,The Pharmaceutical and Drug Industries Research Division
Current Pharmaceutical Analysis | Year: 2011
Three EPMEs based on maltodextrins with different dextrose equivalent (DE) values [I (4.0-7.0), II (13.0-17.0) and III (16.5-19.5)], were designed for the determination of L-vesamicol. The linear concentration ranges of the proposed electrodes were 10 -4 - 10 -2 mol/L for maltodextrin I-based electrode, 10 -5 -10 -3 mol/L for maltodextrin II-based electrode and 10 -9 - 10 -7 mol/L for maltodextrin III-based electrode. The detection limits of the proposed electrodes were 1.34x10 -5, 5.0x10 -6 and 3.33x10 -10 mol/L for maltodextrin I, II and III based electrodes, respectively. The selectivity of EPMEs for L-vesamicol was tested over D-vesamicol, creatine, creatinine and some inorganic ions. The surfaces of the electrodes can be easily renewed by simply polishing on alumina. © 2011 Bentham Science Publishers.