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Patent
Pharma Foods International Co. | Date: 2017-01-04

The present invention provides a novel peptide having bone formation-promoting effect and chondrocyte growth-promoting effect, in particular, a peptide having osteoblast growth-promoting activity, having 100 amino acid residues or less comprising an amino acid sequence selected from(a) Val-Asn-Pro-Glu-Ser-Glu-Glu-Glu-Asp-Glu-Ser-Ser-Pro-Tyr-Glu (SEQ ID NO: 1),(b) an amino acid sequence derived from the amino acid sequence (a) by conservative substitution or deletion of 1 to 3 amino acids, and(c) an amino acid sequence consisting of at least four contiguous amino acids of the amino acid sequence (a) or (b), ora derivative thereof or a salt thereof.


— Global GABA (CAS 56-12-2) Industry Report offers market overview, segmentation by types, application, countries, key manufactures, cost analysis, industrial chain, sourcing strategy, downstream buyers, marketing strategy analysis, distributors/traders, factors affecting market, forecast and other important information for key insight. Companies profiled in this report are Pharma Foods International, Sekisui Chemical, Zhejiang Yiwan Biolabs, Shanghai Richen, Guangdong Luckerkong Biotech, Tianjin Shijitianlong Biotech, Ningxiang Jiayuan Biology Technology, Zhejiang Tianrui Chemical, Taizhou Xinyou Pharmaceutical & Chemical in terms of Basic Information, Manufacturing Base, Sales Area and Its Competitors, Sales, Revenue, Price and Gross Margin (2012-2017). Split by Product Types, with sales, revenue, price, market share of each type, can be divided into • Chemical Synthesis • Biological Fermentation Split by applications, this report focuses on sales, market share and growth rate of GABA (CAS 56-12-2) in each application, can be divided into • Food & Beverage • Animal Feeds • Others Purchase a copy of this report at: https://www.themarketreports.com/report/buy-now/498813 Table of Content: 1 GABA (CAS 56-12-2) Market Overview 2 Global GABA (CAS 56-12-2) Sales, Revenue (Value) and Market Share by Manufacturers 3 Global GABA (CAS 56-12-2) Sales, Revenue (Value) by Countries, Type and Application (2012-2017) 4 Global GABA (CAS 56-12-2) Manufacturers Profiles/Analysis 5 North America GABA (CAS 56-12-2) Sales, Revenue (Value) by Countries, Type and Application (2012-2017) 6 Latin America GABA (CAS 56-12-2) Sales, Revenue (Value) by Countries, Type and Application (2012-2017) 7 Europe GABA (CAS 56-12-2) Sales, Revenue (Value) by Countries, Type and Application (2012-2017) 8 Asia-Pacific GABA (CAS 56-12-2) Sales, Revenue (Value) by Countries, Type and Application (2012-2017) 9 Middle East and Africa GABA (CAS 56-12-2) Sales, Revenue (Value) by Countries, Type and Application (2012-2017) 10 GABA (CAS 56-12-2) Manufacturing Cost Analysis 11 Industrial Chain, Sourcing Strategy and Downstream Buyers 12 Marketing Strategy Analysis, Distributors/Traders 13 Market Effect Factors Analysis 14 Global GABA (CAS 56-12-2) Market Forecast (2017-2022) 15 Research Findings and Conclusion 16 Appendix Inquire more for more details about this report at: https://www.themarketreports.com/report/ask-your-query/498813 For more information, please visit https://www.themarketreports.com/report/2017-2022-global-top-countries-gaba-cas-56-12-2-market-report


Ok W.-J.,Inje University | Cho H.-J.,Konyang University | Kim H.-H.,Inje University | Lee D.-H.,Inje University | And 5 more authors.
Journal of Atherosclerosis and Thrombosis | Year: 2012

Aim: In this study, we investigated the effect of (-)-epigallocatechin-3-gallate (EGCG) on cyclic nucleotide production and vasodilator-stimulated phosphoprotein (VASP) phosphorylation in collagen (10 μg/mL)-stimulated platelet aggregation. Methods: Washed platelets (10 8/mL) from Sprague-Dawley rats (6-7 weeks old, male) were preincubated for 3 min at 37° in the presence of 2 mM exogenous CaCl2 with or without EGCG or other materials, stimulated with collagen (10 μg/mL) for 5 min, and then used for the determination of intracellular cytosolic Ca 2+ ([Ca 2+]i), thromboxane A 2 (TXA 2), adenosine 3',5'-cyclic monophosphate (cAMP), guanosine 3',5'-cyclic monophosphate (cGMP), and VASP phosphorylation. Results: EGCG dose-dependently inhibited collagen-induced platelet aggregation by inhibiting both [Ca 2+]i mobilization and TXA 2 production. Of two aggregation-inhibiting molecules, cAMP and cGMP, EGCG significantly increased intracellular levels of cAMP, but not cGMP. EGCG-elevated cAMP level was decreased by SQ22536, an adenylate cyclase inhibitor, but not by etazolate, a cAMPspecific phosphodiesterase inhibitor. In addition, EGCG elevated the phosphorylation of VASP-Ser 157, a cAMP-dependent protein kinase (A-kinase) substrate, but not the phosphorylation of VASP-Ser 239, a cGMP-dependent protein kinase substrate, in intact platelets and collagen-induced platelets, and VASPSer157 phosphorylation by EGCG was inhibited by both an adenylate cyclase inhibitor SQ22536 and an A-kinase inhibitor Rp-8-Br-cAMPS. We have demonstrated that EGCG increases cAMP via adenylate cyclase activation and subsequently phosphorylates VASP-Ser 157 through A-kinase activation to inhibit [Ca 2+]i mobilization and TXA2 production on collagen-induced platelet aggregation. Conclusions: These results strongly indicate that EGCG is a beneficial compound elevating cAMP level in collagen-platelet interaction, which may result in the prevention of platelet aggregationmediated thrombotic diseases.


Yoto A.,University of Shizuoka | Murao S.,University of Shizuoka | Motoki M.,University of Shizuoka | Yokoyama Y.,Mitsubishi Group | And 5 more authors.
Amino Acids | Year: 2012

γ-Aminobutyric acid (GABA) is a kind of amino acid contained in green tea leaves and other foods. Several reports have shown that GABA might affect brain protein synthesis, improvemany brain functions such asmemory and study capability, lower the blood pressure of spontaneously hypertensive rats, and may also have a relaxation effect in humans. However, the evidence for its mood-improving function is still not sufficient. In this study, we investigated how the oral intake of GABA influences human adults psychologically and physiologically under a condition of mental stress. Sixty-three adults (28 males, 35 females) participated in a randomized, single blind, placebo-controlled, crossoverdesigned study over two experiment days. Capsules containing 100 mg ofGABAor dextrin as a placebowere used as test samples. The results showed that EEG activities including alpha band and beta band brainwaves decreased depending on the mental stress task loads, and the condition of 30 min after GABA intake diminished this decrease compared with the placebo condition. That is to say, GABA might have alleviated the stress induced by the mental tasks. This effect also corresponded with the results of the POMS scores. © 2011 Springer-Verlag.


Thanapreedawat P.,University of Shizuoka | Kobayashi H.,University of Shizuoka | Inui N.,University of Shizuoka | Sakamoto K.,University of Shizuoka | And 4 more authors.
Journal of Nutritional Science and Vitaminology | Year: 2013

γ-Aminobutyric acid (GABA) is an amino acid found in unpolished rice, chocolate, tea, and other foods. It is an important inhibitory neurotransmitter. However, the influence of GABA on object recognition and working memory is still unknown. In this study, the effects of GABA on novel object recognition (NOR) memory and working memory were examined. The proper retention interval and delay time were also investigated for the NOR test and T-maze test, respectively. Male 3-wk-old Wistar rats were allowed free access to food and water containing 0.5% GABA or 1% GABA for a month. After that, the rats performed the NOR test at a 48 h retention interval and T-maze test at a 900 s delay time to estimate the effects of GABA on learning behavior. The results showed that the object information in the NOR test was stored as long-term memory and the recognition index (RI) was significantly increased after GABA administration. The accuracy rate also significantly increased after GABA administration. These indicate that GABA may be involved in long-term object recognition memory and working memory.


Yamamoto H.,Osaka University | Awada C.,Osaka University | Awada C.,Pharma Foods International Co. | Matsumoto S.,Osaka University | And 4 more authors.
Journal of Cell Science | Year: 2015

Wnt5a regulates planar cell polarity in epithelial cells, but it remains to be determined whether Wnt5a and its receptors are sorted apically or basolaterally, and how Wnt5a signaling is involved in apical and basolateral polarization. We found that Wnt5a was secreted basolaterally in polarized kidney epithelial cells. The basolateral secretion of Wnt5a required Wntless (Wls), clathrin and adaptor protein 1 (AP-1). Wnt5a receptors were also localized to the basolateral membranes, but their sorting did not require Wls. Wnt5a-induced signaling was stimulated more efficiently at the basolateral side than the apical side of epithelial cells. Knockdown of Wnt5a delayed apical lumen formation of the epithelial cyst, and these phenotypes were rescued by wild-type Wnt5a, but not by a Wnt5a mutant that is secreted apically. Although apoptosis was not required for apical lumen formation in a wild-type cyst, apoptosis was necessary for eliminating luminal cells in a Wnt5a-depleted cyst. These results suggest that Wnt5a and its receptors are sorted to their correct destination by different mechanisms and that the basolateral secretion of Wnt5a is necessary for apical lumen formation in the epithelial cyst. © 2015. Published by The Company of Biologists Ltd.


Takeshima K.,Pharma Foods International Co. | Yamatsu A.,Pharma Foods International Co. | Yamashita Y.,Pharma Foods International Co. | Watabe K.,Pharma Foods International Co. | And 3 more authors.
Food and Chemical Toxicology | Year: 2014

γ-Aminobutyric acid (GABA) is an amino acid compound contained in vegetables such as tomatoes and also widely distributed in mammals. GABA acts as an inhibitory neurotransmitter and promotes parasympathetic activity to provide several beneficial effects, for instance, relaxation, anti-stress, and insomnia. GABA, produced via a fermentation process, has been available as a functional food ingredient. As part of a program to assess its safety, GABA was administered by oral gavage at doses of 500, 1250, and 2500. mg/kg body weight to groups of 10 male and 10 female Sprague-Dawley rats for 13. weeks. Treatment was not associated with the test substance-related mortality and appeared to be well tolerated. There were no toxicologically and statistically significant changes in urinalysis, hematology, clinical chemistry parameters, and in necropsy findings. A few statistically significant changes in food consumption and body weights were noted in the male groups while any significant changes were not noted in female groups. There was no effect of treatment on organ weights or on the results of the histopathological examinations. The results of toxicity evaluation support the safety use of GABA and the potential use as a functional food ingredient. © 2014 Elsevier Ltd.


PubMed | Pharma Foods International Co.
Type: Clinical Trial | Journal: Journal of nutritional science and vitaminology | Year: 2015

The effects of two food materials, -aminobutyric acid (GABA) produced by natural fermentation and Apocynum venetum leaf extract (AVLE), on the improvement of sleep were investigated in humans. The electroencephalogram (EEG) test revealed that oral administration of GABA (100 mg) and AVLE (50 mg) had beneficial effects on sleep. GABA shortened sleep latency by 5.3 min and AVLE increased non-rapid eye movement (REM) sleep time by 7.6%. Simultaneous intake of GABA and AVLE shortened sleep latency by 4.3 min and increased non-REM sleep time by 5.1%. The result of questionnaires showed that GABA and AVLE enabled subjects to realize the effects on sleep. These results mean that GABA can help people to fall asleep quickly, AVLE induces deep sleep, and they function complementarily with simultaneous intake. Since both GABA and AVLE are materials of foods and have been ingested for a long time, they can be regarded as safe and appropriate for daily intake in order to improve the quality of sleep.


Patent
Pharma Foods International Co. | Date: 2015-02-25

The present invention provides a novel peptide having bone formation-promoting effect and chondrocyte growth-promoting effect, in particular, a peptide having osteoblast growth-promoting activity, having 100 amino acid residues or less comprising an amino acid sequence selected from (a) Val-Asn-Pro-Glu-Ser-Glu-Glu-Glu-Asp-Glu-Ser-Ser-Pro-Tyr-Glu (SEQ ID NO: 1), (b) an amino acid sequence derived from the amino acid sequence (a) by conservative substitution or deletion of 1 to 3 amino acids, and(c) an amino acid sequence consisting of at least four contiguous amino acids of the amino acid sequence (a) or (b), ora derivative thereof or a salt thereof.


Patent
Pharma Foods International Co. | Date: 2013-07-04

The present invention provides a novel active ingredient which can be safely used in preventing, ameliorating or treating diseases related to the cartilage such as cartilage damages and cartilage disorders. Since the egg yolk protein hydrolyzate has an effect on chondrocyte proliferation promotion, it is useful as an active ingredient for preventing, ameliorating or treating cartilage disorders and for preventing, ameliorating or treating joint pain. The egg yolk protein hydrolyzate is a natural-origin material with high safety and, therefore, can be widely used in foods and drinks, medicines, feeds and the like which can be daily ingested.

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