PHARM REGION Ltd

Moscow, Russia

PHARM REGION Ltd

Moscow, Russia

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Klykov S.P.,PHARM REGION Ltd | Kurakov V.V.,PHARM REGION Ltd | Vilkov V.B.,PHARM REGION Ltd | Demidyuk I.V.,Russian Academy of Sciences | And 2 more authors.
Biofabrication | Year: 2011

In this paper we have proposed a new structured population growth model, further developing a model previously proposed by the authors. Based on this model, optimal growth characteristics of the recombinant strain Escherichia coli BL-21 (DE3) [pProPlnHis 6] were determined, which allowed us to increase the output of metalloproteinase by 300%. We have experimentally demonstrated the applicability of the new model to cell cultures with implanted plasmids and the potential practical use for an output increase of a wide variety of biosynthesis processes. © 2011 IOP Publishing Ltd.


In this paper we have proposed a new structured population growth model, further developing a model previously proposed by the authors. Based on this model, optimal growth characteristics of the recombinant strain Escherichia coli BL-21 (DE3) [pProPlnHis(6)] were determined, which allowed us to increase the output of metalloproteinase by 300%. We have experimentally demonstrated the applicability of the new model to cell cultures with implanted plasmids and the potential practical use for an output increase of a wide variety of biosynthesis processes.

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