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Bhatia M.S.,University of Delhi | Kaur N.,Dr Rml Pgimer And Hospital
Journal of Clinical and Diagnostic Research | Year: 2014

Pagophagia is a particular form of pica characterized by ingestion of ice, freezer frost or iced drinks often associated with iron or calcium deficiency. It occurs due to a complex interplay in between behavioural components. Only few cases of pagophagia have been reported from India.We report a case, a married lady, who presented with pagophagia and responded to fluoxetine.


Balhara Y.P.S.,Dr RML PGIMER and Hospital | Jain R.,All India Institute of Medical Sciences | Dhawan A.,All India Institute of Medical Sciences | Mehta M.,All India Institute of Medical Sciences
Journal of Substance Use | Year: 2011

Background: Pheniramine is being used harmfully in combination with opiates and benzodiazepines through injecting route. However, the abuse liability of pheniramine has not been studied in humans. Aim: The present study is an attempt to analyze the abuse liability of pheniramine in human subjects. Materials and methodology: The study used a double-blind randomly allotted crossover design. The doses of the drugs used were placebo (normal saline) 2 mL, pheniramine maleate 45.5 mg and lorazepam 2 mg. The assessments were made at baseline and then at 15, 120 and 240 min. The subjects were assessed for the sociodemographic profile, drug-use history, physiological parameters (pulse rate, BP, respiratory rate), and Modified Single-Dose Questionnaire (MSDQ)/ MorphineBenzedrine Group Scale (MBG)/PentobarbitalChlorpromazineAlcohol Group Scale (PCAG)/Visual Analog Scale (VAS)/Profile of Mood States (POMS) scale. Analysis: Analysis was carried out using SPSS version 10.0. In-between drug comparisons were done using one-way analysis of variance (ANOVA) (multiple comparisons). Results: MSDQ and PCAG showed comparable results between the two compounds. VAS and POMS scale had significant increase on the scale for both lorazepam and pheniramine. Conclusions: The findings suggest the possible abuse liability of pheniramine. These findings with the clinical observation of pheniramine abuse used in combination with injection buprenorphine and diazepam warrant the need of caution while prescribing the compound to individuals. © 2011 Informa UK, Ltd.


Duggal S.,Dr Baba Saheb Ambedkar Hospital | Kaur N.,Dr Rml Pgimer And Hospital | Hans C.,Dr Rml Pgimer And Hospital
Journal of Clinical and Diagnostic Research | Year: 2011

Introduction: MRSA (Methicillin Resistant Staphylococcus aureus) deserves special attention in health care settings. It becomes difficult to treat this infection/eradicate its colonization once it has established. However, its spread can be controlled. An increase in MRSA isolation from the wound swabs of the burns patients over a period of four months prompted us to undertake the present investigation. Material and Methods: Eleven HCWs (Health Care workers) were screened. Hand smears and nasal swabs were cultured and identified by standard microbiological methods. A re-orientation programme was arranged for all HCWs in the burns ward and the importance of standard work precautions, especially hand hygiene was highlighted. Swabs were taken from the same workers after six weeks. Results: Out of eleven health care workers, seven were found to be MRSA carriers (63.6%). Swabs which were taken from the same workers after six weeks, revealed a decrease in the MRSA colonization in the hands by 75% and in the nose by 25%. Also, the number of MRSA isolations from the wound swabs of patients in the burns ward decreased from 35.3% to 13.9%. Conclusion: The current study emphasizes the need for an early diagnosis of MRSA and for being vigilant so that if any outbreak of multidrug resistant organisms occurs in a ward/ ICU, steps to control them can be initiated at the earliest. Italso highlights the importance of hand hygiene so that the hands that deliver care may not deliver germs.

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