Dhule, India
Dhule, India

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Vartale S.P.,Pg Research Center | Pawde A.V.,A E S College | Halikar N.K.,Pg Research Center | Kalyankar N.D.,Pg Research Center | Pawar Y.D.,Pg Research Center
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

A series of total fifteen novel Quinoline Schiff bases [4a-e,5a-e,6a-e] were prepared from 6/7 substituted quinoline carbaldehyde. All quinoline schiff bases were refluxed with thioacetic acid in presence of anhydrous zinc chloride and solvent N,N-dimethyl formamide to afforded novel series of 4-thiazolidinone (7a-e,8a-e,9a-e). All synthesized 4-thiazolidinone were screened for their antimicrobial activity.


Rajput A.P.,Pg Research Center | Rajput T.A.,Rc Patel Acs College
Biotechnology | Year: 2012

The present study aim was to identify and characterize the active principles from the leaves of Corchorusfascicularis Lam. For isolation of compounds, the dried leaves powder of Corcizorusfascicularis Lam. was subjected to cold maceration with ethanol as solvent and subjected to column chromatography. Two compounds were isolated and purified by methanol. Mass spectrum of EEC-i and EEC-2 showed a parent molecular ion peak at m/z 302 and 290 which corresponds to molecular formula C15H1407 and C 5H 406. From physical, chemical and spectral characteristics EEC-i and EEC-2 were concluded as Quercetin and Catechin © 2012 Asian Network for Scientific Information.


Formylation of N-substituted phenyl succinimides was carried out by using Vilsmeier-Haack reagent which formed 2,5-dichloro-3,4-diformyl (N-substituted Phenyl) pyrroles (III) compounds. Compounds (III) was treated with ethylene glycol in presence of PTSA to get dioxolane derivatives (IV) which on further treatment with hydrazine hydrate formed compound (V) described in (Scheme-I). The synthesis of Schiffbases (VI) by treating 2 moles of substituted aromatic primary amines with 1 mole of compound (III). This compound (VI) on treatment with 2 moles of thioglycolic acid formed corresponding 4-thiazolidinone derivatives (VII) of 2,5-dichloro-3,4-diformyl (Nsubstituted phenyl) pyrroles. (Scheme-II).


Vartale S.P.,Pg Research Center | Halikar N.K.,Pg Research Center | Sirsat S.B.,Pg Research Center | Pawar Y.D.,Pg Research Center
Journal of Heterocyclic Chemistry | Year: 2013

Pyrazolo pyrimido pyrimidine (4a-k) was prepared by the reaction of compound 3-cyano-4-imino-2-(methylthio)4H-pyrido[1,2-a]pyrimidine (3) with hydrazine hydrate, phenyl hydrazine, 2-hydrazino benzothiazole, and 6-substituted hydrazine benzothiazole in N,N-dimethylformamide and anhydrous potassium carbonate. These synthesized compounds were characterized by elemental analysis IR, 1H NMR, and mass spectral data. © 2013 HeteroCorporation.


Vartale S.P.,Pg Research Center | Kadam D.B.,Pg Research Center | Halikar N.K.,Pg Research Center
Der Pharma Chemica | Year: 2011

A series of novel tetrazoloquinoline schiff's bases 3a-g, 4a-g, 5a-g, 6a-g, 7a-g were prepared from 6/7/8-trisubstituted quinoline carbaldehyde. All tetrazolo quinoline Schiff bases were refluxed with thioacetic acid in presence of anhydrous zinc chloride and solvent N, N-dimethyl formamide to afforded novel series of 4-thiazolidinone 8a-g, 9a-g, 10a-g, 11a-g, 12a-g.All synthesized 4-thiazolidinone were screened for their antimicrobial activity.


Vartale S.P.,Pg Research Center | Halikar N.K.,Pg Research Center | Pawar Y.D.,Pg Research Center
Journal of Chemistry | Year: 2013

The 2-amino-7-methoxypyrimido[4,5-b]quinoline (1) on treatment with bis(methylthio)methylene malononitrile (2) in ethyl alcohol and catalytic amount of TEA gives 3-cyano-4-imino-9-methoxy-2-methythio-4H-pyrimido[2,1-b] pyrimido[4,5-b]quinoline (3). The latter were further reacted with selected N-, O-, and C-nucleophiles such as aryl amines, hetryl amines, substituted phenols, and compounds containing an active methylene group. © 2013 S. P. Vartale et al.


Vartale S.P.,Pg Research Center | Sirsat S.B.,Pg Research Center | Halikar N.K.,Pg Research Center
Heterocyclic Communications | Year: 2013

Simple and efficient synthesis of a novel fused bicyclic heterocyclic compound 3 by the reaction of ethyl 2-cyano-3,3-bis(methylthio)acrylate and thiourea in the presence of potassium carbonate in dimethylformamide under reflux conditions is reported. The optimized molar ratio of the substrates is 2:1. The parent compound was used for further derivatization by using a synthetic strategy that is based on suitability of the substituted pyrimido[2,1-b][1,3]thiazine system to react as a bis-electrophilic species with various nucleophiles. Products 4a-e and 5a-e were obtained in good yields (65-76%). © 2013 Walter de Gruyter GmbH, Berlin/Boston.

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