PG Research

Melvisharam, India

PG Research

Melvisharam, India
SEARCH FILTERS
Time filter
Source Type

Arish D.,University of Limoges | Shiju C.,HLL Lifecare Ltd | Joseyphus R.S.,PG & Research | Pushparajan J.,Travancore Titanium Products Ltd.
Materials Chemistry and Physics | Year: 2017

Preceramic polymer zirconoborosiloxane was synthesized from the reaction with boric acid, diphenyldiethoxysilane and zirconium (IV) propoxide via solventless process. The thermogravimetric analysis of the polymer showed that ceramic yield as decomposition product at 900 °C was 71%. The pyrolysis of zirconoborosiloxane in an argon gas environment was investigated as standard pyrolytic process up to 1650 °C. Microstructure evolution of ceramic phases was made by means of Fourier transform infrared, Raman spectroscopy, X-ray diffraction and scanning electron microscope analysis. The results clearly demonstrated the pyrolysis products at 1650 °C consist of totally non-oxide ceramic phases of β-SiC, ZrB2 and free carbon. © 2017 Elsevier B.V.


Palani S.,Anna Bioresearch Foundation | Raja S.,Bharat Institute of Technology | Kumar R.P.,Anna Bioresearch Foundation | Parameswaran P.,Anna Bioresearch Foundation | Kumar B.S.,PG Research
Acta Pharmaceutica Sciencia | Year: 2010

Acorus calamus (AC) is a traditional medicinal plant that is commonly used for disorder of central nervous system abnormalities. In ayurvedic medicine, it is used for the treatment of insomnia, melancholia, epilepsy, hysteria, loss of memory remittent fevers and neurosis. This plant extract is mainly used for various pharmacological activities like antidiabetic, antiproliferative, immunosuppressive, antidiarrhoeal and hypolipidemic activities. The main constituents of AC were found belonging to monoterpene, sesquiterpene, phenylpropanoid, flavonoid and quinone. The aim of this study was to investigate the nephroprotective and antioxidant activities of ethanol extract of AC at two dose levels of 250 and 500 mg/kg B/W on acetaminophen (APAP) induced toxicity in male albino rats. APAP significantly increased levels of serum urea, hemoglobin (Hb), total leukocyte count, packed cell volume, creatinine, DLC, and mean corpuscular volume, raised body weight, and reduced levels of neutrophils, mean corpuscular Hb content, mean corpuscular hematocrit, granulocytes, uric acid, and platelet Concentration. AC inhibited the hematological effects of APAP. AC significantly increased activities of renal superoxide dismutase, catalase, glutathione, and glutathione peroxidase and decreased malondialdehyde content of APAP-treated rats. Apart from these, histopathological changes also showed the protective nature of the AC extract against APAPinduced necrotic damage of renal tissues. In conclusion it was observed that the ethanol extract of AC conferred nephroprotective and antioxidant activities by histopathological and biochemical observations against APAP induced renal damage in rats.


Palani S.,Anna Bioresearch Foundation | Palani S.,PG Research | Raja S.,Bharat Institute of Technology | Senthil Kumar B.,PG Research
International Journal of PharmTech Research | Year: 2010

Chloroxylon swietenia is a folklore medicinal plant that is commonly used for antimicrobial, antifertility, analgesic, insecticidal, antifeedant activities The present study was aimed to investigate the hepatoprotective and antioxidant activities of ethanol extract of Chloroxylon swietenia (250mg/kg & 500 mg/kg B/W) on acetaminophen (APAP) induced rat hepatic injury. The development of hepatotoxicity induced by APAP is promoted by oxidative stress. APAP treated group significantly (p<0.01) elevated the serum enzymatic levels like serum glutamate pyruvate transaminase (ALT), serum glutamate oxaloacetate transaminase (AST), serum alkaline phosphatase (SALP) and total bilirubin, which were restored towards normalization significantly (p<0.01) by the ethanol extract of Chloroxylon swietenia in a dose dependent manner. In addition, this plant extract significantly (p<0.01) elevated the decreased level of antioxidant enzymes such as glutathione peroxidase (GPX), catalase (CAT), glutathione-s-transferase (GST) superoxide dismutase (SOD) and reduced glutathione (GSH). Biochemical and Histopathological observations confirmed the beneficial roles of ethanol extract of Chloroxylon swietenia against acetaminophen induced liver injury in rats. Histological analysis of the liver of these rats revealed marked necro-inflammatory changes by APAP and ethanol extract of Chloroxylon swietenia attenuated the necro-inflammatory changes in the liver. The activity of ethanol extract of Chloroxylon swietenia (500 mg/kg B/W) was comparable to the standard drug silymarin (25mg/kg B/W).


Palani S.,Anna Bioresearch Foundation | Raja S.,Bharat Institute of Technology | Kumar R.P.,Anna Bioresearch Foundation | Selvaraj R.,Anna Bioresearch Foundation | Kumar B.S.,PG Research
Pakistan Journal of Pharmaceutical Sciences | Year: 2011

Monochoria vaginalis is an herbaceous medicinal plant used to treat, liver problems India. Acetaminophen is a commonly used analgesic and antipyretic agent which, at high doses, causes liver and kidney necrosis in man and animals. The aim of the present study is to evaluate phytoconstituents and investigate the nephroprotective & antioxidant activities of the ethanol extract of Monochoria vaginalis on acetaminophen induced toxicity in rats. Phytoconstituents like n-hexadecanoic acid, 3-methyl- acetate-1-butanol, 1,1,3-triethoxy- propane, Z,Z,Z-1,4,6,9 - nonadecatetraene, undecanoic acid, 3-trifluoroacetoxy penta decane and 4-ethyl-5-octyl-2,2-bis (trifluoromethyl) - cis-1,3-dioxalone were identified from ethanol extract of Monochoria vaginalis by using a gas chromatograph-mass spectrograph (GC MS). Biochemical studies show that there is an increase in the levels of serum urea and creatinine along with an increase in the body weight and reduction in the levels of uric acid in acetaminophen induced groups. These values are retrieved significantly by treatment with Monochoria vaginalis extracts at two different doses. The antioxidant studies reveal that the levels of renal SOD, CAT, GSH and GPx in the APAP treated animals are increased significantly along with a reduced MDA content in ethanol extract of Monochoria vaginalis treated groups. Apart from these, histopathological changes also reveal the protective nature of the Monochoria vaginalis extract against acetaminophen induced necrotic damage of renal tissues. In conclusion, these data suggest that the ethanol extract of Monochoria vaginalis can prevent renal damage from APAP induced nephrotoxicity in rats and it is likely to be mediated through active phytoconstituents and its antioxidant activities.


Palani S.,Anna Bioresearch Foundation | Kumar S.N.,Anna Bioresearch Foundation | Kumar B.S.,PG Research
Natural Product Research | Year: 2011

Salacia oblonga, a woody climbing plant belonging to the family Celastaceae, is widely distributed in India and other southeast Asian countries. The genus Salacia have been used particularly for the treatment of diabetes, obesity, gonorrhoea, rheumatism, pruritus and asthma. Acetaminophen (APAP), used as an analgesic drug, produces liver and kidney necrosis in mammals at high doses. The aim of this study was to investigate the nephroprotective and antioxidant activities of the ethanol extract of Salacia oblonga (EESO) at the two dose levels of 250 and 500mg/kgbw on APAP-induced toxicity in rats. The results showed that APAP significantly increases the levels of serum urea, creatinine, and reduces levels of uric acid concentration. The EESO reduces these by increasing anti-oxidative responses as assessed by biochemical and histopathological parameters. In conclusion, our results suggest that the EESO possesses nephroprotective and antioxidant effects against APAP-induced nephrotoxicity in rats. © 2011 Copyright Taylor and Francis Group, LLC.


Miyazaki T.,Tohoku University | Miyauchi S.,PG Research | Anada T.,Tohoku University | Imaizumi H.,Tohoku University | Suzuki O.,Tohoku University
Analytical Biochemistry | Year: 2011

Osteoclasts are involved in bone resorption, and its activation is considered one of the causes of osteoporosis. The pit assay is the principal method for evaluating osteoclast function by measuring hydroxyapatite resorption in vitro. However, the pit assay requires time and trained techniques, including the pit image analysis, and there is no other easy method for evaluating bone resorption. In this study, we developed a novel approach to quantify the bone resorption activity using a calcium phosphate (CaP) coating labeled with fluorescent polyanion. Fluoresceinamine-labeled chondroitin polysulfate or Hoechst 33258-labeled deoxyribonucleic acid was used for CaP labeling. When macrophage cell line RAW264 was cultured on the labeled CaP under the stimulation with the receptor activator of the NF-κB ligand (RANKL), RAW264 cells differentiated into osteoclastic cells and the fluorescence intensity of the culture supernatant and pit area increased in a time- and dose-dependent manner. Furthermore, drugs for osteoporosis treatment, such as pamidronate and β-estradiol, inhibited fluorescein release by the cells stimulated with RANKL. A positive correlation between the fluorescence intensity and pit area was observed (r = 0.917). These results indicated that this new method using fluorescent polyanion-labeled CaP is a standardized useful assay system for the evaluation of bone resorption activity. © 2010 Elsevier Inc. All rights reserved.


Siva S.,PG Research | Siva S.,Alagappa Chettiar College of Engineering And Technology | Sudharsan S.,Dhanalakshmi College of Engineering | Sayee Kannan R.,PG Research
RSC Advances | Year: 2015

The present work showed the synthesis of Ion Exchange Resin-Silver nanoparticles (IER-AgNPs) by impregnating ecofriendly synthesized AgNPs within a IER and its application as a novel polymer based hybrid nanocomposite for highly efficient removal of mercury (Hg2+) from aqueous solution. The nature of the synthesized IER-AgNPs was structurally and thermally characterized. When compared to resorcinol-formaldehyde resin (RFR) and IER, the synthesized nanocomposites revealed tremendous selectivity for Hg2+ removal from aqueous medium in the non-existence and existence of opposing ions Ca2+, Mg2+ and Na+ at much greater levels than the target poisonous metal. It was found that the potential Donnan membrane effect exerted by the immobilized negatively charged sulfonic acid groups bound to the macroporous cation exchanger of IER result in preconcentration and penetration enhancement of Hg2+ ions prior to their effective segregation by the impregnated AgNPs. Moreover, adsorption isotherms, kinetics, intraparticle diffusion and thermodynamics for the removal of Hg2+ were analyzed. Besides, breakthrough curves were found from column flow studies using the synthetic solution. 10% (w/w) HCl was used as an effective eluting agent for the regeneration of exhausted ion exchangers. Hence, IER-AgNPs cation-exchange resin could be efficiently used for the removal of mercury(ii) ions from aqueous solution. © The Royal Society of Chemistry 2015.


Vijay T.,Bharathiar University | Vijay T.,P.A. College | Rajan M.S.D.,P.A. College | Sarumathy K.,Bharathiar University | And 3 more authors.
Journal of Applied Pharmaceutical Science | Year: 2011

Doxorubicin (DOX) is a widely used cancer chemotherapeutic agent. However, it generates free oxygen radicals that result in serious dose-limiting cardiotoxicity. Supplementations with Gmelina arborea (Verbenaceae) were proven effective in reducing oxidative stress associated with several ailments. The aim of the current study was to investigate the potential protective effect of Gmelina arborea (GA) against DOX- induced cardiotoxicity in rats. GA was given orally to rats(250&500mg/kg) and DOX (20mg/kg) was administered on the seventh day. GA protected against DOX-induced increased the levels of marker enzymes. It significantly inhibited DOX-provoked glutathione (GSH) depletion in cardiac tissues. The reductions of cardiac activities of catalase (CAT) ,superoxide dismutase (SOD) ,glutathione peroxidase (GSH-Px) and glutathione reductase (GR) were significantly mitigated. Pretreatment of GA significantly guarded against DOX-induced rise of serum lactate dehydrogenase (LDH). GA alleviated histopathological changes in rats' hearts treated with DOX. In conclusion, GA protects against DOX-induced cardiotoxicity in rats. The study can be attributed, at least in part, to GA's antioxidant activity.


Palani S.,Anna Bioresearch Foundation | Raja S.,Bharat Institute of Technology | Kalash R.S.,Anna Bioresearch Foundation | Kumar B.S.,PG Research
Toxicological and Environmental Chemistry | Year: 2010

Mahonia leschenaultia takeda (Berberidaceae) (MLT) is a traditional medicinal plant that is commonly used to treat and improve liver and renal conditions in India and other Asian countries. Acetaminophen (APAP) is commonly used as an analgesic and an antipyretic agent that, in high doses, produces liver and kidney necrosis in mammals. The aim of this study was to investigate the nephroprotective and antioxidant activities of the ethanol extract of MLT at two dose levels of 250 and 500 mg kg-1 bw on APAP-induced toxicity in rats. APAP significantly increased levels of serum urea, hemoglobin (Hb), total leukocyte count, creatinine, packed cell volume, DLC, and mean corpuscular volume, raised body weight, and reduced levels of neutrophils, mean corpuscular Hb content, mean corpuscular hematocrit, granulocytes, uric acid, and platelet concentration. MLT inhibited the hematological effects of APAP. MLT significantly increased activities of renal superoxide dismutase, catalase, glutathione, and glutathione peroxidase and decreased malondialdehyde content of APAP-treated rats. Apart from these, histopathological changes also showed the protective nature of the MLT extract against APAP-induced necrotic damage of renal tissues. In conclusion, data suggest that the ethanol extract of MLT prevented renal damage from APAP-induced nephrotoxicity in rats and it is likely mediated through antioxidant activities. © 2010 Taylor & Francis.


Palani S.,Anna Bioresearch Foundation | Palani S.,PG Research | Raja S.,Bharat Institute of Technology | Naresh R.,Anna Bioresearch Foundation | Kumar B.S.,PG Research
Toxicology Mechanisms and Methods | Year: 2010

Plectranthus amboinicus (PA), commonly known as country borage, is a folkoric medicinal plant. Juice from its leaves is commonly used for illnesses including liver and renal conditions in the Asian sub-continent. Acetaminophen (APAP), used as an analgesic, produces liver and kidney necrosis in mammals at high doses. The aim of this study was to investigate the nephroprotective, diuretic, and antioxidant activities of the ethanol extract of PA at two doses of 250 and 500 mg/kg bw on APAP-induced toxicity in rats. This study shows that APAP significantly increases the levels of serum urea (UR), hemoglobin (Hb), total leukocyte count, creatinine, raised body weight, and reduced levels of neutrophils, granulocytes, uric acid, and platelet concentration. Ethanol extract of PA rescued these phenotypes by increasing anti-oxidative responses as assessed by biochemistry and histopathology. In addition, the ethanol extract of PA at two doses showed a significant diuretic activity by increased levels of total urine output and urinary elerolytes such as sodium and potassium. In conclusion, these data suggest that the ethanol extract of PA possess nephroprotective and antioxidant effects against APAP-induced nephrotoxicity and strong diuretics effect in rats. © 2010 Informa UK Ltd.

Loading PG Research collaborators
Loading PG Research collaborators