PG Institute

Indore, India

PG Institute

Indore, India

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Mishra P.K.,PG Institute | Tomar J.,PG Institute | Sane M.R.,PG Institute | Saxena D.,PG Institute | Yadav A.,PG Institute
Journal of Indian Academy of Forensic Medicine | Year: 2016

Deaths due to fire or burns usually result from application of dry heat to the body. In India there are several thousands of deaths occurring due to fire or burns. Unfortunately vast majority of these cases occur in the home and are due to smoking, defective electrical wiring, defective kerosene stove bursts, attempted suicides by self-immolation, homicidal burns of young women by husband or in-laws (Dowry deaths/bride burning). The present study was based on retrospective analysis of burn cases in the period from January 2013 to December 2013 from autopsies done in the Department of Forensic Medicine and Toxicology, SAIMS Medical College & PG Institute, Indore, M.P. It was observed that more than half of the victims died of burn injuries were married women. Females are mostly involved in cooking and most common cause is accidental burn. Burns having total body surface area (TBSA) more than 40% were fatal. The different aspects of burn deaths are analyzed and discussed in detail.


Bajpai T.,PG Institute | Pandey M.,IGNOU | Varma M.,PG Institute | Bhatambare G.S.,PG Institute
Indian Journal of Pathology and Microbiology | Year: 2014

Context: Antimicrobial resistance showed by different uropathogens is one of the barricades that might hinder a successful treatment. Detection of extended spectrum beta-lactamase (ESBL) production among uropathogens is an important marker of endemicity. Aims: The present prospective study was done to identify the trends of uropathogens, to find the prevalence of ESBL isolates and to study the antibiotic resistance profile of the ESBL and non-ESBL uropathogenic isolates. Materials and Methods: This study was conducted in the Department of Microbiology of a teaching tertiary care hospital from July 2013 to September 2013. All the uropathogenic isolates were identified up to species level by conventional methods. The prevalence of potential ESBL producers was explored. Antibiotic resistance test of the urinary isolates was done by disc-diffusion method and the results were interpreted according to Clinical Laboratory Standards Institute-2013 guidelines. Results: A total of 670 urine samples from male and female patients visiting the outpatient department (OPD) and inpatient department (IPD) of our hospital were collected. A significantly higher number of IPD and OPD males (55.1% and 55.5%) were found to be culture positive. Escherichia coli (55.3%) was the most frequently isolated uropathogen followed by Klebsiella pneumoniae (23%). However, strains of Escherichia coli (41.6%) were the highest ESBL producing isolates followed by Pseudomonas aeruginosa (36.1%). ESBL producing isolates were found to be multidrug-resistant when compared to non-ESBL producers. However, excessive drug-resistance among non-ESBL producing isolates can't be ignored. Conclusion: Our study confirms a global trend toward increased resistance to beta-lactam antibiotics. We emphasize on the formulation of antibiotic policy for a particular geographical area.


Chakrabarti P.R.,PG Institute | Dosi S.,PG Institute | Varma A.,PG Institute | Kiyawat P.,PG Institute | And 2 more authors.
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: Testicular and para-testicular neoplasm is rare type of tumours affecting adolescents and young adults, reflected by the paucity of published data in India. Aim: This study was undertaken to estimate the epidemiological characteristics and histological types and subtypes of testicular neoplasm according to the WHO classification in our patient group. Identification of histopathological pattern of testicular tumour is immensely important for improved management protocols. Materials and Methods: This was a retrospective study done over a period of ten years from 2004 to 2014 in a tertiary care centre. All relevant clinical data including patient’s age, laterality, history of risk factors and serum tumour markers were collected from records. Histopathological slides were retrieved and reviewed for tumour and its subtype and classified according to WHO classification (2004). Results: A total of 37 cases of testicular and paratesticular neoplasm were encountered in our study with a mean age of 38.1 years. Right testis was affected in 70.3% of cases. The most common clinical presentation was scrotal swelling with heaviness. Germ cell tumour was the most common type accounting for 77.1% followed by lymphomas (17.1%). Germ cell tumours were categorized into seminomatous (48.2%) and non-seminomatous tumours (51.8%). The most common subtype of non-seminomatous tumours was mixed germ cell tumour accounting for 85.8%. Conclusion: The incidence of testicular neoplasm among general population in Asian countries is low, as reflected in the very few studies that have been performed and published in literature. Epidemiological and histomorphological spectrum of our study was comparable to most of the countries except for some African and Western countries. © 2016, Journal of Clinical and Diagnostic Research. All Rights Reserved.


OBJECTIVE: A cross-sectional study was done to assess the size of thymus in term healthy infants using sonography and to assess its variation in size, shape, location, echogenicity and echotexture for both male and female reference population. MATERIAL AND METHODS: A total of 250 term healthy neonates of either sex were subjected to thymic sonography. The shape, size in maximal anteroposterior, longitudinal, and transverse dimensions of both right and left lobes of thymus was evaluated. Their echotexture and echogenicity were determined and standards for reference population were calculated. The results were statistically evaluated. RESULTS: According to the shape; the thymus was quadrilateral in 156 neonates (62%), round in 37 (15%), bilobate in 32 (13%), and crescent shaped in 25 (10%) in transverse scan. According to the echo texture, the thymus echogenicity was homogeneous and almost similar or slightly less to that of the liver and spleen in most cases 200 [80%] and was coarse in 50 (20%). In all subjects, the echogenicity of the thymus was less than that of the thyroid gland. Variations in location of the thymus were found in 70 (28%) neonates. The range of mean AP diameter was 0.39-2.36 cm (mean 1.43±0.3), that of transverse 1.4-4.3 cm (mean 2.16±0.54) and that of thymic index 1.2-5.1 cm2 (mean 2.98±0.64). CONCLUSIONS: A normative range was calculated for standard population, which can be used as a reference for comparing thymus size for both normal and diseased neonates for various immunological diseases. © 2015 IOS Press and the authors. All rights reserved.


Sodani A.,PG Institute | Chawla A.,PG Institute | Maheshwari A.,PG Institute | Naigaonkar M.,PG Institute | Porwal V.,PG Institute
Neurology India | Year: 2012

Extramedullary hematopoiesis is a compensatory response in patients with thalassemia and other chronic anemia and can result in compressive myelopathy, if untreated. Two young adults with history of thalassemia presented with symptoms of spinal cord compression. Presence of extramedullary hematopoiesis was confirmed by magnetic resonance imaging. Both the patients were treated with blood hypertransfusion and showed improvement clinically and radiologically. Although there are various options in the management of such condition, including decompression surgery and radiation treatment, hypertransfusion can be very effective even in severe compression of the spinal cord. Hypertransfusion should be tried as the first line of management in patients with thalassemia presenting with compressive myelopathy to decrease the bulk of extramedullary hematopoietic tissue.


Raut A.,Pg Institute | Jadhav S.,Pg Institute | Vora R.,Pg Institute | Mandke J.,Pg Institute | And 2 more authors.
Journal of Pediatric Surgery | Year: 2010

We describe a neonate in whom a right congenital diaphragmatic hernia and an anorectal malformation coexisted. Their coexistence in the same patient is rare. © 2010 Elsevier Inc. All rights reserved.


Kinger M.,PG Institute | Chakrabarti P.R.,PG Institute | Sharma S.,PG Institute | Kiyawat P.,PG Institute
Annals of Tropical Medicine and Public Health | Year: 2014

Filariasis, a tropical parasite infection, is a common public health problem in the Indian sub-continent. Occurrence of filariasis with chronic myeloid leukemia (CML) is unusual though there are case reports of leishmaniasis, malaria, and other vector-borne diseases seen in association with leukemias. Filariasis co-existing with CML has not been documented to the best of our knowledge and hence definitely needs a space in literature. We report an incidental finding of bancroftian filariasis in a 35-year-old female already diagnosed as CML.


Nema N.,PG Institute | Ishrat S.,PG Institute | Verma A.,PG Institute | Kela M.,Sri Aurobindo Medical College and PG Institute
Oman Journal of Ophthalmology | Year: 2016

A 23-year-old man with a history of alcoholism presented with vomiting, fever, and sharp epigastric pain radiating to the back and flanks. He was diagnosed as a case of acute alcoholic pancreatitis on the basis of clinical findings and investigations. On the next day of presentation, he developed sudden bilateral visual loss. His best-corrected visual acuity was finger counting at one-foot distance in both eyes. He had diffuse whitening in the circumpapillary area, haloes around the retinal vessels (Purtscher flecken) and intra-retinal hemorrhages on ophthalmoscopic examination. Optical coherence tomography revealed bilateral macular edema. These findings were characteristic of Purtscher-like retinopathy. The patient showed systemic and visual improvement at 8 weeks follow-up after receiving the conventional treatment for acute alcoholic pancreatitis. This case emphasizes the importance of fundus examination by an ophthalmologist in the diagnosis of this rare under-diagnosed entity. © 2016 Oman Ophthalmic Society | Published by Wolters Kluwer - Medknow.


Kumar R.,PG Institute | Arya V.,Sir Ganga Ram Hospital | Agarwal S.,Sanjay Gandhi Post Graduate Institute of Medical Sciences
Advances in Hematology | Year: 2015

Mutation spectrum varies significantly in different parts and different ethnic groups of India. Social factors such as preference to marry within the community and among 1st degree relatives (consanguinity) play an important role in impeding the gene pool of the disease within the community and so in society by and large. The present paper discusses the role of consanguinity in profiling of beta thalassemia mutation, and thus the approach for prenatal screening and prevention based awareness programme. Clinically diagnosed 516 cases of beta thalassemia were screened at molecular level. A detailed clinical Proforma was recorded with the information of origin of the family, ethnicity, and consanguinity. The present study reports that subjects originating from Uttar Pradesh, Uttarakhand, Bihar, and Jharkhand have c.92+5G>C and c.124-127delTTCT mutation as the commonest mutation compared to the subjects hailing from Madhya Pradesh and Chhattisgarh and Nepal where sickle mutation was found more common. In 40 consanguineous unions more common and specific beta mutations with higher rate of homozygosity have been reported. This consanguinity-based data helps not only in deciding target oriented prenatal diagnostic strategies but also in objective based awareness programmes in prevention of thalassemia major birth. © 2015 Ravindra Kumar et al.


Jadhav S.,Pg Institute | Raut A.,Pg Institute | Mandke J.,Pg Institute | Patil S.,Pg Institute | And 2 more authors.
Journal of Indian Association of Pediatric Surgeons | Year: 2013

Aim: To study the effect of nonclosure of rectourethral (RU) fistula and to do a comparative analysis of the complications with and without nonclosure of RU fistula during posterior sagittal anorectoplasty (PSARP) in anorectal malformation cases (ARM). Materials and Methods: A total of 68 cases of ARM were included in the study group, of which 34 cases were those in whom RU fistula was not closed (group A) during PSARP. Another 34 successive cases were included in study group B in whom the RU fistula was closed as is conventionally done by using interrupted sutures. Results: Comparatively, group A had none or minimum urological complications as compared to Group B. Conclusion: RU fistula closure is not mandatory during PSARP and nonclosure avoids urological complications. It especially avoids urethral complications, which are 100% preventable.

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