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Thanjāvūr, India

Kumar S.V.,AVVM Sri Pushpam College | Mani P.,Tamilvel Umamaheswaranar Karanthai ArtsCollege | Bastin J.T.M.M.,Tamilvel Umamaheswaranar Karanthai ArtsCollege | Kumar R.A.,PG and Research Laboratory | Ravikumar G.,AVVM Sri Pushpam College
International Journal of Pharmacy and Technology | Year: 2011

The acetone, chloroform, hexane, petroleum ether and ethanol extracts of Annona squamosa leaf was studied against the early fourth-instar larvae of Aedes aegypti, Anopheles stephensi, and Culex quinquefasciatus. The larval mortality was observed after 24 h exposure. All extracts showed moderate larvicidal effects; however, the highest larval mortality was found in the petroleum ether extract. In the present study, bioassay-guided fraction of Annona squamosa led to the separation and identification of a saponin as a potential mosquito larvicidal compound, with LCinf50/inf and LCinf90/inf value of 219.41, 394.87 ppm against Aedes aegypti, and 118.4, 273.10 ppm against An. stephensi and 342.6, 616.70 ppm against Cx. quinquefasciatus, respectively. In oviposition deterrent activity, the highest concentration of (0.1%) Annona squamosa produce 99.6% against Anopheles stephensi, 92.4% against Culex Quinquefasciatus and 92.4% against Aedes aegypti respectively. Skin repellent test at 0.02 ppm concentration of Annona squamosa gives the complete protection time ranges from 50.4 to 271 minutes. The plant exerted the highest protection time of 126.2 minutes. GC-MS analysis data confirmed the identification of the active compound. This study investigates the potential of crude extracts from commonly used medical herbs in India as an environmentally safe measure to control the vector of dengue, malaria, and lymphatic filariasis. Source


John Bastin T.M.M.,PG and Research Laboratory | Mani P.,AVVM Sri Pushpam College | Arun Kumar R.,PG and Research Laboratory | Arumugam M.,Annamalai University
Research Journal of Pharmacy and Technology | Year: 2011

The aim of the present study was designed to compare the possible therapeutic effects of Terminalia arjuna and Murraya koenigii methanolic extracts against diabetes. Serum glucose level, lipid profile and pancreas histology were estimated after administration of the extracts. Applied doses did not cause any acute toxicity or behavioral changes. In conclusion, T. arjuna produced a significant hypoglycemic effect while M. koenigii prove to have a hypolipidemic activity at dose level of 200 mg/kg. © RJPT All right reserved. Source

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