News Article | May 8, 2017
Architectural Glass & Cladding has put their reputation behind the trusted and innovative products of Okalux GmbH. -- Architectural Glass & Cladding has put their reputation behind the trusted and innovative products of Okalux GmbH. Since 2010, their close partnership has helped the architectural community to discover the advantages of energy efficiency, end user comfort and the use of natural daylight to reduce the running costs of buildings throughout Australia and South East Asia."Our goal is to develop optimum solutions to satisfy architects specific demands – with glass," said Paul Nipperess, Sales and Marketing Manager of Architectural Glass & Cladding. AG&C has more than 20 years experience in the glass and façade industries."Okalux has decades of experience in the development and manufacture of high quality insulating glass for international construction projects. The very first product which sparked off the idea for the founding of the company also set the standard for its powers of innovation. Hollow fibres, which were originally conceived for the textiles industry, produce great advantages when inserted in the space between the panes of a window: they produce a soft diffusion of daylight and deep illumination of interiors," said Paul.This was followed by systems for light deflection and improved diffusion, transparent heat insulation and energy reduction. Paul goes on to say, "Glass is one of the most fascinating materials available to architects. It allows natural light into buildings and contributes decisively towards the end user's comfort. Okalux has dedicated itself to using natural light and ensuring that its products produce a balance of often contradictory demands; supplying a building with light and thermal energy while simultaneously protecting against overheating, heat loss and UV radiation." Because of this, Paul has called on architects, designers and builders to keep windows on their radar early by "creating purpose built solutions."This partnership between Okalux and Architectural Glass and Cladding has provided solutions to many key projects by utilising many of the unique and innovative Okalux products. These projects include: 570 Bourke Street Melbourne, Australian Catholic University NSW, Australian War Memorial ACT, The Peter Doherty Institute (University of Melbourne), Illumin8 Building (Adelaide University), Malaiwana Estate (Phuket Thailand), and 5 Martin Place (Sydney). Projects currently under construction include Monash University (Melbourne), and the Hong Kong Art Museum.For more information contact Architectural Glass & Cladding Pty Ltd, Suite 17, Wharf Central, 75 Wharf Street, Tweed Heads NSW 2485, phone 07 5523 2335, fax 07 5523 2336, email: firstname.lastname@example.org ( mailto://info@ agcproducts.com.au ), website: http://www.agcproducts.com.au
Towns J.M.,Melbourne Sexual Health Center |
Leslie D.E.,Peter Doherty Institute |
Denham I.,Melbourne Sexual Health Center |
Azzato F.,Peter Doherty Institute |
And 4 more authors.
Sexually Transmitted Infections | Year: 2016
Background Chancres, the hallmark of primary syphilis, are classically described as single, painless ulcers at the site of Treponema pallidum inoculation. We aimed to determine the frequency of painful or multiple anogenital lesions of primary syphilis among men, whether there was concurrent herpes simplex virus (HSV) infection and whether HIV status altered clinical presentations. Methods This study was conducted among men with T. pallidum PCR-positive lesions, attending a clinic in Melbourne, Australia, between 2009 and 2014. Lesions were also tested with HSV PCR, and syphilis serology undertaken. Results 183 men with T. pallidum PCR-positive primary anogenital lesions were included. 89% were men who have sex with men, and 10.9% were heterosexual. 38 men (20.8%) were HIV positive. Anal lesions were more common in HIV-positive men (34.2%) than in HIV-negative men (11.6%). Primary lesions were frequently painful (49.2%) or multiple (37.7%), and infrequently associated with HSV (2.7%). Of 37 men with both painful and multiple primary lesions, only 8% had concurrent HSV. Presentation was not significantly altered by HIV status. Conclusions Primary syphilis lesions are often painful and/or multiple in the absence of herpes coinfection, and may be clinically misdiagnosed.
Abbott I.J.,Peter Doherty Institute |
Peleg A.Y.,Alfred HospitalVIC |
Peleg A.Y.,Monash University
Seminars in Respiratory and Critical Care Medicine | Year: 2015
Stenotrophomonas maltophilia, Achromobacter xylosoxidans, and nonmelioid Burkholderia species, namely, Burkholderia cepacia complex, collectively are a group of troublesome nonfermenters. Although not inherently virulent organisms, these environmental Gram negatives can complicate treatment in those who are immunocompromised, critically ill in the intensive care unit and those patients with suppurative lung disease, such as cystic fibrosis. Through a range of intrinsic antimicrobial resistance mechanisms, virulence factors, and the ability to survive in biofilms, these opportunistic pathogens are well suited to persist, both in the environment and the host. Treatment recommendations are hindered by the difficulties in laboratory identification, the lack of reproducibility of antimicrobial susceptibility testing, the lack of clinical breakpoints, and the absence of clinical outcome data. Despite trimethoprim-sulfamethoxazole often being the mainstay of treatment, resistance is widely encountered, and alternative regimens, including combination therapy, are often used. This review will highlight the important aspects and unique challenges that these three nonfermenters pose, and, in the absence of clinical outcome data, our therapeutic recommendations will be based on reported antimicrobial susceptibility and pharmacokinetic/pharmacodynamic profiles.
PubMed | Peter Doherty Institute, Melbourne Sexual Health Center and Monash University
Type: Journal Article | Journal: Sexually transmitted infections | Year: 2016
Chancres, the hallmark of primary syphilis, are classically described as single, painless ulcers at the site of Treponema pallidum inoculation. We aimed to determine the frequency of painful or multiple anogenital lesions of primary syphilis among men, whether there was concurrent herpes simplex virus (HSV) infection and whether HIV status altered clinical presentations.This study was conducted among men with T. pallidum PCR-positive lesions, attending a clinic in Melbourne, Australia, between 2009 and 2014. Lesions were also tested with HSV PCR, and syphilis serology undertaken.183 men with T. pallidum PCR-positive primary anogenital lesions were included. 89% were men who have sex with men, and 10.9% were heterosexual. 38 men (20.8%) were HIV positive. Anal lesions were more common in HIV-positive men (34.2%) than in HIV-negative men (11.6%). Primary lesions were frequently painful (49.2%) or multiple (37.7%), and infrequently associated with HSV (2.7%). Of 37 men with both painful and multiple primary lesions, only 8% had concurrent HSV. Presentation was not significantly altered by HIV status.Primary syphilis lesions are often painful and/or multiple in the absence of herpes coinfection, and may be clinically misdiagnosed.
PubMed | Peter Doherty Institute, Monash University and University of Melbourne
Type: Journal Article | Journal: BMC infectious diseases | Year: 2016
Many nations maintain stockpiles of neuraminidase inhibitor (NAI) antiviral agents for use in influenza pandemics to reduce transmission and mitigate the course of clinical infection. Pandemic preparedness plans include the use of these stockpiles to deliver proportionate responses, informed by emerging evidence of clinical impact. Recent uncertainty about the effectiveness of NAIs has prompted these nations to reconsider the role of NAIs in pandemic response, with implications for pandemic planning and for NAI stockpile size.We combined a dynamic model of influenza epidemiology with a model of the clinical care pathways in the Australian health care system to identify effective NAI strategies for reducing morbidity and mortality in pandemic events, and the stockpile requirements for these strategies. The models were informed by a 2015 assessment of NAI effectiveness against susceptibility, pathogenicity, and transmission of influenza.Liberal distribution of NAIs for early treatment in outpatient settings yielded the greatest benefits in all of the considered scenarios. Restriction of community-based treatment to risk groups was effective in those groups, but failed to prevent the large proportion of cases arising from lower risk individuals who comprise the majority of the population.These targeted strategies are only effective if they can be deployed within the constraints of existing health care infrastructure. This finding highlights the critical importance of identifying optimal models of care delivery for effective emergency health care response.
Ebert G.,Walter and Eliza Hall Institute of Medical Research |
Ebert G.,University of Melbourne |
Preston S.,Walter and Eliza Hall Institute of Medical Research |
Preston S.,University of Melbourne |
And 25 more authors.
Proceedings of the National Academy of Sciences of the United States of America | Year: 2015
Hepatitis B virus (HBV) infection can result in a spectrum of outcomes from immune-mediated control to disease progression, cirrhosis, and liver cancer. The host molecular pathways that influence and contribute to these outcomes need to be defined. Using an immuno-competent mouse model of chronic HBV infection, we identified some of the host cellular and molecular factors that impact on infection outcomes. Here, we show that cellular inhibitor of apoptosis proteins (cIAPs) attenuate TNF signaling during hepatitis B infection, and they restrict the death of infected hepatocytes, thus allowing viral persistence. Animals with a liver-specific cIAP1 and total cIAP2 deficiency efficiently control HBV infection compared with WT mice. This phenotype was partly recapitulated in mice that were deficient in cIAP2 alone. These results indicate that antagonizing the function of cIAPs may promote the clearance of HBV infection. © 2015, National Academy of Sciences. All rights reserved.
Patterson Ross Z.,University of Sydney |
Komadina N.,Peter Doherty Institute |
Deng Y.-M.,Peter Doherty Institute |
Spirason N.,Peter Doherty Institute |
And 5 more authors.
PLoS Pathogens | Year: 2015
The factors that determine the characteristic seasonality of influenza remain enigmatic. Current models predict that occurrences of influenza outside the normal surveillance season within a temperate region largely reflect the importation of viruses from the alternate hemisphere or from equatorial regions in Asia. To help reveal the drivers of seasonality we investigated the origins and evolution of influenza viruses sampled during inter-seasonal periods in Australia. To this end we conducted an expansive phylogenetic analysis of 9912, 3804, and 3941 hemagglutinnin (HA) sequences from influenza A/H1N1pdm, A/H3N2, and B, respectively, collected globally during the period 2009-2014. Of the 1475 viruses sampled from Australia, 396 (26.8% of Australian, or 2.2% of global set) were sampled outside the monitored temperate influenza surveillance season (1 May – 31 October). Notably, rather than simply reflecting short-lived importations of virus from global localities with higher influenza prevalence, we documented a variety of more complex inter-seasonal transmission patterns including “stragglers” from the preceding season and “heralds” of the forthcoming season, and which included viruses sampled from clearly temperate regions within Australia. We also provide evidence for the persistence of influenza B virus between epidemic seasons, in which transmission of a viral lineage begins in one season and continues throughout the inter-seasonal period into the following season. Strikingly, a disproportionately high number of inter-seasonal influenza transmission events occurred in tropical and subtropical regions of Australia, providing further evidence that climate plays an important role in shaping patterns of influenza seasonality. © 2015 Patterson Ross et al.
Bruggink L.D.,Peter Doherty Institute |
Dunbar N.L.,Peter Doherty Institute |
Marshall J.A.,Peter Doherty Institute
Journal of Virological Methods | Year: 2015
The sensitivity and specificity of the R-Biopharm RIDA®QUICK (N1402) immunochromatography assay for norovirus detection was examined using fecal material from Australian gastroenteritis incidents. The study involved the analysis of 3 groups of specimens; group 1 comprised 100 norovirus open reading frame (ORF) 1 RT-PCR positive specimens; group 2 comprised 100 ORF 1 RT-PCR norovirus negative specimens and group 3 comprised 12 specimens containing common gastroenteritis viruses other than norovirus. The RIDA®QUICK (N1402) assay detected both GI and GII norovirus and had an overall sensitivity of 87%. Genotype analysis of the capsid region of the genome (ORF 2) indicated the RIDA®QUICK (N1402) assay could detect a range of genotypes including GI.1, GI.2, GI.3, GI.4, GI.5, GII.3, GII.4 (including variants GII.4 (2009-like), GII.4 (2012), GII.4 (2012-like) and GII.4 (unknown)), GII.6, GII.13 and GII.21. The assay had good sensitivity for both GI and GII norovirus. The assay had a specificity of 97% and did not cross react with a number of common fecal viruses. However, one of eight rotavirus positive, norovirus negative specimens gave a positive result; rotavirus cannot be taken as the cause of such a false positive but cannot be excluded either. The kit was quick and easy to use and would be valuable in point-of-care testing. © 2015 Elsevier B.V.
PubMed | Peter Doherty Institute
Type: Journal Article | Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology | Year: 2015
Human immunodeficiency virus (HIV) management is entering a universal test and treat phase, although the benefits from this approach in developed world scenarios are uncertain. We analyzed 79 combination anti-retroviral therapy (cART)-nave HIV-positive individuals who were intensively prospectively followed from 2004 to 2013. We studied HIV-related illnesses, potential HIV transmissions, impact on sexual behavior, and factors impeding earlier cART initiation. Sixty-eight (86 %) subjects commenced cART at a mean of 6.0 years after diagnosis: 71 % with a CD4 T-cell count <350 cells/l. A significant minority of subjects (29 %) resisted initiation of cART despite physician recommendation for a mean of 18 months. Only one HIV-related illness occurred in a patient who had not previously recorded a CD4 T-cell count <500 cell/l, totaling 195 person-years of observation. A 40 % increase in sexually transmitted infections (STIs) occurred after commencing cART. We detected six HIV transmissions in our cohort, all of which were before initiating cART and 5 of them had a prior CD4 T-cell count <500 cells/l. Illnesses related to cART deferral were rare and most HIV transmissions we detected occurred in people with a prior CD4 T-cell count <500 cells/l. Our study raises concerns about increasing STI rates after cART initiation. Focusing resources on cART initiation among patients with CD4 T-cell counts <500 cells/l and enhancing safe sexual practices should remain a priority.
PubMed | Peter Doherty Institute
Type: Journal Article | Journal: Australian and New Zealand journal of public health | Year: 2016
Annual influenza vaccination is recommended for all Australian healthcare workers (HCWs). In 2014, a target vaccination uptake of 75% was set for Victorian healthcare facilities. This study aimed to determine the 2014 uptake, describe trends over time and propose an enhanced reporting framework.Annual data submitted to the Victorian Healthcare Associated Infection Surveillance System (VICNISS) regarding HCW influenza were evaluated for 2005-2014. Faculty uptake - the number of vaccinations administered divided by total number of staff employed - was reported as a statewide aggregate and stratified by facility size (number of staff employed).In 2014, 78,885 HCWs were vaccinated across 93 healthcare facilities, corresponding to an overall uptake of 72.2%. During 2005-2014, small facilities (<100 HCWs) generally reported highest uptake while larger facilities (800 HCWs) recorded lowest uptake. Larger facilities recorded the greatest increase (+13.9%) when 2013 and 2014 seasons were compared. For all healthcare facility size categories, the highest uptake was observed in 2014.Influenza vaccination uptake in HCWs has successfully been introduced as a performance indicator in Victorian healthcare facilities and a peak uptake was reported in 2014. Varied trends are evident when uptake is stratified by number of employed HCWs, providing a feasible and meaningful method for benchmarking.