Kuklina E.M.,Russian Academy of Sciences |
Smirnova E.N.,Perm State Medical University |
Nekrasova I.V.,Russian Academy of Sciences |
Balashova T.S.,Perm State Medical University
Doklady Biological Sciences | Year: 2015
The antigen-presenting activity of B cells and expression of molecules involved in antigen presentation by B cells have been studied in patients with autoimmune thyroiditis (AIT). The disease is characterized by enhanced expression of the costimulatory molecule CD80 in naive B cells (CD19+CD27− cells) both ex vivo and under the conditions of polyclonal cell activation in a culture. Under in vitro conditions, antigen-loaded B cells have been shown to be capable of inducing proliferation of autologous CD4+ cells, in particular, proliferation of autospecific T cells in patients with AIT. Given that an intense infiltration of thyroid tissue by B cells is a typical sign of AIT, the antigen-presenting activity of B cells appears to contribute to this pathology. © 2015, Pleiades Publishing, Ltd.