Perm State Medical University

Perm’, Russia

Perm State Medical University

Perm’, Russia
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Kuklina E.M.,Russian Academy of Sciences | Smirnova E.N.,Perm State Medical University | Nekrasova I.V.,Russian Academy of Sciences | Balashova T.S.,Perm State Medical University
Doklady Biological Sciences | Year: 2015

The antigen-presenting activity of B cells and expression of molecules involved in antigen presentation by B cells have been studied in patients with autoimmune thyroiditis (AIT). The disease is characterized by enhanced expression of the costimulatory molecule CD80 in naive B cells (CD19+CD27− cells) both ex vivo and under the conditions of polyclonal cell activation in a culture. Under in vitro conditions, antigen-loaded B cells have been shown to be capable of inducing proliferation of autologous CD4+ cells, in particular, proliferation of autospecific T cells in patients with AIT. Given that an intense infiltration of thyroid tissue by B cells is a typical sign of AIT, the antigen-presenting activity of B cells appears to contribute to this pathology. © 2015, Pleiades Publishing, Ltd.

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