Perm State Pharmaceutical Academy

Perm’, Russia

Perm State Pharmaceutical Academy

Perm’, Russia
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El'kina O.V.,Perm State Pharmaceutical Academy | Shramm N.I.,Perm State Pharmaceutical Academy | Molokhova E.I.,Perm State Pharmaceutical Academy
Pharmaceutical Chemistry Journal | Year: 2014

Optimization of the extraction of biologically active substances from yellow toadflax produced data indicating that the active principles were extracted most completely from raw material if vacuum-filtration extraction was used. The process was carried out with heating at 42°C, infusion for 40 min, and solid:liquid phase ratio 1:10. The yield of extracted flavonoids under these conditions was 96.7% of the total content in the raw material; of iridoids, 93.8%. The selected parameters could be considered optimal and recommended as industrial processing parameters for further production of extracts and their integration into medical practice. © 2014 Springer Science+Business Media.


Surikova O.V.,Perm State Pharmaceutical Academy | Mikhailovskii A.G.,Perm State Pharmaceutical Academy | Syropyatov B.Y.,Perm State Pharmaceutical Academy | Vakhrin M.I.,Perm State Pharmaceutical Academy
Pharmaceutical Chemistry Journal | Year: 2015

A series of 2-(3-methyl-6-methoxy-7-ethoxy-3,4-dihydroisoquinolyl-1)ethanoic acid amides were synthesized via cyclocondensation of O-ethylated eugenol with cyanoacetic acid amides. Hydrochlorides of the synthesized compounds were shown to exhibit anthelmintic activity. The unsubstituted amide was the most active and exhibited activity equal to that of levamisole and significantly greater than that of pyrantel. The insecticidal activity of the synthesized compounds was inferior to that of imidacloprid. © 2015, Springer Science+Business Media New York.


Surikova O.V.,Perm State Pharmaceutical Academy | Mikhailovskii A.G.,Perm State Pharmaceutical Academy | Odegova T.F.,Perm State Pharmaceutical Academy
Pharmaceutical Chemistry Journal | Year: 2015

3-Substituted [3,4-dihydroisoquinolin-1(2H)-ylidene]acetonitriles were synthesized via replacement of Cl by a cyano group in the corresponding 1-chloromethylisoquinolines. The hydrochlorides of the synthesized compounds exhibited weak antimicrobial and antifungal activities. The maximum activity against Staphylococcus aureus, Escherichia coli, and Candida albicans was observed for the compound with a 3-spiro-cyclopentyl radical, the MIC of which was 250 μg/mL. © 2015, Springer Science+Business Media New York.


Gein V.L.,Perm State Pharmaceutical Academy | Odegova T.F.,Perm State Pharmaceutical Academy | Yankin A.N.,Perm State Pharmaceutical Academy | Nosova N.V.,Perm State Pharmaceutical Academy
Pharmaceutical Chemistry Journal | Year: 2015

Series of N,N′,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides were synthesized in good yields via the reaction of N-arylacetoacetamides and aromatic aldehydes in EtOH in the presence of piperidine. The synthesized compounds were tested for antimicrobial activity. © 2015, Springer Science+Business Media New York.


Kalinin D.V.,Perm State Pharmaceutical Academy | Kalinina S.A.,Perm State Pharmaceutical Academy | Dolzhenko A.V.,University of Selangor | Dolzhenko A.V.,Curtin University Australia
Heterocycles | Year: 2013

The amino substituted triazine ring was annelated to aminoazoles using a new effective synthetic procedure. The method of preparation involved initial formation of azolylformamidines in the reaction of aminoazoles with N,N-dimethylformamide dimethyl acetal followed by the triazine ring closure with cyanamide affording therefore fused aminotriazines. © 2013 The Japan Institute of Heterocyclic Chemistry.


Dolzhenko A.V.,University of Selangor | Dolzhenko A.V.,Curtin University Australia | Kalinina S.A.,Perm State Pharmaceutical Academy | Kalinin D.V.,Perm State Pharmaceutical Academy
RSC Advances | Year: 2013

A novel multicomponent strategy for the efficient synthesis of 5-aza-adenines was developed. 5-Aza-adenines were prepared in a one-pot fashion from 5-amino-1,2,4-triazoles, cyanamide and triethyl orthoformate under microwave irradiation. The operational simplicity, efficiency and accessibility of this method make it highly attractive for the generation of bioactive compound libraries. © 2013 The Royal Society of Chemistry.


Kalinina S.A.,Perm State Pharmaceutical Academy | Kalinin D.V.,Perm State Pharmaceutical Academy | Dolzhenko A.V.,Sunway University | Dolzhenko A.V.,Curtin University Australia
Tetrahedron Letters | Year: 2013

A new, efficient, catalyst-free, one-pot, three-component method for the synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines using 3,5-diamino-1,2,4-triazoles, cyanamide, and triethyl orthoformate is developed. The reaction proceeds smoothly under microwave-assisted heating. Advantages of the method include using easily available reagents, short reaction times, and operational simplicity. © 2013 Elsevier Ltd. All rights reserved.


Korkotian E.,Weizmann Institute of Science | Bombela T.,Perm State Pharmaceutical Academy | Odegova T.,Perm State Pharmaceutical Academy | Zubov P.,Perm State Pharmaceutical Academy | Segal M.,Weizmann Institute of Science
PLoS ONE | Year: 2013

The effects of ethanol on neuronal network activity were studied in dissociated cultures of rat hippocampus. Exposure to low (0.25-0.5%) ethanol concentrations caused an increase in synchronized network spikes, and a decrease in the duration of individual spikes. Ethanol also caused an increase in rate of miniature spontaneous excitatory postsynaptic currents. Higher concentrations of ethanol eliminated network spikes. These effects were reversible upon wash. The effects of the high, but not the low ethanol were blocked by the GABA antagonist bicuculline. The enhancing action of low ethanol was blocked by apamin, an SK potassium channel antagonist, and mimicked by 1-EBIO, an SK channel opener. It is proposed that in cultured hippocampal networks low concentration of ethanol is associated with SK channel activity, rather than the GABAergic receptor. © 2013 Korkotian et al.


Kalinin D.V.,Perm State Pharmaceutical Academy | Kalinina S.A.,Perm State Pharmaceutical Academy | Dolzhenko A.V.,Curtin University Australia
Heterocycles | Year: 2012

The triazine ring bearing a trichloromethyl group was annelated to various aminoazoles using a new effective synthetic procedure. The method of preparation involved initial formation of trichloroacetamidines in the reaction of aminoazoles with trichloroacetonitrile followed by the triazine ring closure with triethyl orthoformate affording therefore the titled compounds. © 2012 The Japan Institute of Heterocyclic Chemistry.


Korkotian E.,Weizmann Institute of Science | Botalova A.,Perm State Pharmaceutical Academy | Odegova T.,Perm State Pharmaceutical Academy | Segal M.,Weizmann Institute of Science
NeuroToxicology | Year: 2015

The effects of chronic exposure to moderate concentrations of ethanol were studied in cultured hippocampal neurons. Network activity, assessed by imaging of [Ca2+]i variations, was markedly suppressed following 5 days of exposure to 0.25-1% ethanol. The reduced activity was sustained following extensive washout of ethanol, but the activity recovered by blockade of inhibition with bicuculline. This reduction of network activity was associated with a reduction in rates of mEPSCs, but not in a change in inhibitory synaptic activity. Chronic exposure to ethanol caused a significant reduction in the density of mature dendritic spines, without an effect on dendritic length or arborization. These results indicate that chronic exposure to ethanol causes a reduction in excitatory network drive in hippocampal neurons adding another dimension to the chronic effects of alcohol abuse. © 2015 Elsevier Inc.

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