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Gein V.L.,Perm State Pharmaceutical Academy | Mar'Yasov M.A.,Perm State Pharmaceutical Academy
Russian Journal of Organic Chemistry | Year: 2015

Three-component condensation of methyl 4-(furan-2-yl)- and 4-(thiophen-2-yl)-2,4-dioxobutanoates with aromatic aldehydes and 1,3-thiazol-2-amine afforded 5-aryl-4-(hetaren-2-ylcarbonyl)-3-hydroxy-1-(1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrol-2-ones. Reactions of the latter with hydrazine and phenylhydrazine gave pyrrolo[3,4-c]pyrazol-6-ones and 3-phenylhydrazones, while the corresponding oximes were obtained in reactions with hydroxylamine. © 2015 Pleiades Publishing, Ltd.


Korkotian E.,Weizmann Institute of Science | Botalova A.,Perm State Pharmaceutical Academy | Odegova T.,Perm State Pharmaceutical Academy | Segal M.,Weizmann Institute of Science
NeuroToxicology | Year: 2015

The effects of chronic exposure to moderate concentrations of ethanol were studied in cultured hippocampal neurons. Network activity, assessed by imaging of [Ca2+]i variations, was markedly suppressed following 5 days of exposure to 0.25-1% ethanol. The reduced activity was sustained following extensive washout of ethanol, but the activity recovered by blockade of inhibition with bicuculline. This reduction of network activity was associated with a reduction in rates of mEPSCs, but not in a change in inhibitory synaptic activity. Chronic exposure to ethanol caused a significant reduction in the density of mature dendritic spines, without an effect on dendritic length or arborization. These results indicate that chronic exposure to ethanol causes a reduction in excitatory network drive in hippocampal neurons adding another dimension to the chronic effects of alcohol abuse. © 2015 Elsevier Inc.


Molokhova E.I.,Perm State Pharmaceutical Academy | Sorokina Yu.V.,Perm State Pharmaceutical Academy
Antibiotiki i Khimioterapiya | Year: 2015

Rheological properties of mild pharmaceutical formulations (creams) with glucocorticosteroids, such as Triderm (Belgium), Akriderm GK (Russia) and Kanizon plus (India) were studied. The study revealed differences in the structural-strength properties of the medicines (viscosity, critical shear stress). The necessity of rheological investigations during development of generic medicines was shown.


Kalinina S.A.,Perm State Pharmaceutical Academy | Kalinin D.V.,Perm State Pharmaceutical Academy | Dolzhenko A.V.,Sunway University | Dolzhenko A.V.,Curtin University Australia
Tetrahedron Letters | Year: 2013

A new, efficient, catalyst-free, one-pot, three-component method for the synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines using 3,5-diamino-1,2,4-triazoles, cyanamide, and triethyl orthoformate is developed. The reaction proceeds smoothly under microwave-assisted heating. Advantages of the method include using easily available reagents, short reaction times, and operational simplicity. © 2013 Elsevier Ltd. All rights reserved.


Kalinin D.V.,Perm State Pharmaceutical Academy | Kalinina S.A.,Perm State Pharmaceutical Academy | Dolzhenko A.V.,University of Selangor | Dolzhenko A.V.,Curtin University Australia
Heterocycles | Year: 2013

The amino substituted triazine ring was annelated to aminoazoles using a new effective synthetic procedure. The method of preparation involved initial formation of azolylformamidines in the reaction of aminoazoles with N,N-dimethylformamide dimethyl acetal followed by the triazine ring closure with cyanamide affording therefore fused aminotriazines. © 2013 The Japan Institute of Heterocyclic Chemistry.

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