Perm State Medical Academy

Perm’, Russia

Perm State Medical Academy

Perm’, Russia
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Gein V.L.,Perm State Pharmaceutical Academy | Gein L.F.,Perm State Medical Academy | Platonov V.S.,Perm State Pharmaceutical Academy
Russian Journal of General Chemistry | Year: 2014

Reactions of 1,4,5-trisubstituted 3-hydroxy-3-pyrrolin-2-ones with diphenyldiazomethane yield the O-alkylation products. Thermolysis of 1,5-diaryl-4-heteroyl-3-hydroxy-3-pyrrolin-2-ones is accompanied with suprafacial [1,5]-sigmatropic rearrangement. © 2014 Pleiades Publishing, Ltd.


Mizeva I.,Institute of Continues Media Mechanics | Dumler A.,Perm State Medical Academy | Muraviev N.,St. Petersburg State Medical University
BIOSIGNALS 2014 - 7th Int. Conference on Bio-Inspired Systems and Signal Processing, Proceedings; Part of 7th Int. Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2014 | Year: 2014

Peripheral arterial occlusive disease (PAOD) of increasing severity can lead progressively to disabling claudication, ischemic rest pain and gangrene. The blood supply of a limb with peripheral arterial disease is restored by surgical operations, which treats the critical limb ischemia (CLI) only in 30% of the cases. CLI occurs when the arterial lumen decreases significantly and the nutritive requirements of the tissues, supplied by microcirculation, cannot be met. In the present paper, a simple, non-invasive and low-cost technique is proposed for early screening diagnosis of PAOD. The approach is based on the investigation of the spectral characteristics of pulse waves measured by photoplethysmography. Painless, versatility and simplicity are significant merits of the proposed methodology. Copyright © 2014 SCITEPRESS - Science and Technology Publications. All rights reserved.


Bratsun D.A.,Perm State University | Merkuriev D.V.,Perm State Medical Academy | Zakharov A.P.,Technion - Israel Institute of Technology | Pismen L.M.,Technion - Israel Institute of Technology
Journal of Biological Physics | Year: 2016

We propose a multiscale chemo-mechanical model of cancer tumor development in epithelial tissue. The model is based on the transformation of normal cells into a cancerous state triggered by a local failure of spatial synchronization of the circadian rhythm. The model includes mechanical interactions and a chemical signal exchange between neighboring cells, as well as a division of cells and intercalation that allows for modification of the respective parameters following transformation into the cancerous state. The numerical simulations reproduce different dephasing patterns—spiral waves and quasistationary clustering, with the latter being conducive to cancer formation. Modification of mechanical properties reproduces a distinct behavior of invasive and localized carcinoma. © 2015, Springer Science+Business Media Dordrecht.


PubMed | Perm State Medical Academy, Technion - Israel Institute of Technology and Perm State University
Type: Journal Article | Journal: Journal of biological physics | Year: 2016

We propose a multiscale chemo-mechanical model of cancer tumor development in epithelial tissue. The model is based on the transformation of normal cells into a cancerous state triggered by a local failure of spatial synchronization of the circadian rhythm. The model includes mechanical interactions and a chemical signal exchange between neighboring cells, as well as a division of cells and intercalation that allows for modification of the respective parameters following transformation into the cancerous state. The numerical simulations reproduce different dephasing patterns--spiral waves and quasistationary clustering, with the latter being conducive to cancer formation. Modification of mechanical properties reproduces a distinct behavior of invasive and localized carcinoma.


Smirnova E.,Perm State Medical Academy | Podtaev S.,RAS Institute of Continuous Media Mechanics | Mizeva I.,RAS Institute of Continuous Media Mechanics | Loran E.,Perm State Medical Academy
Diabetes and Vascular Disease Research | Year: 2013

The objective of this study is to explore changes in microvascular tone during a contralateral cold pressor test and to compare the results obtained in healthy subjects and in patients with impaired glucose tolerance (IGT) and type 2 diabetes. Low-amplitude fluctuations of skin temperature in the appropriate frequency ranges were used as a characteristic for the mechanism for vascular tone regulation. In total, 13 adults with type 2 diabetes aged 40-67 years and 18 adults with IGT aged 31-60 years participated in this pilot study. The control group included 12 healthy men and women aged 39-60 years. The response to the cold pressor test in patients with type 2 diabetes and with IGT differs essentially from that of healthy subjects in the endothelial frequency range. Endothelial dysfunction occurs in the preclinical stage of diabetes and manifests, in particular, as a disturbance of the endothelial part of vascular tone regulation. © 2013 The Author(s).


Belyaev A.Y.,RAS Institute of Continuous Media Mechanics | Gileva O.S.,Perm State Medical Academy | Zuev A.L.,RAS Institute of Continuous Media Mechanics | Muraveva M.A.,Perm State Medical Academy
Key Engineering Materials | Year: 2014

The paper is concerned with the study of the elastic properties of dental enamel and its destruction by a microindentation technique. A series of experiments were performed to find differences in the mechanical properties of healthy and diseased dental enamel. It has been found that the times of dental enamel destruction in healthy and carious areas under a constant force are different. The effect of an infiltrated photopolymer on the hardness and elastic modulus of dental enamel was investigated by microindentation testing. A comparative analysis of the features of healthy, damaged by caries and treated by photopolymer enamel was carried out. © (2014) Trans Tech Publications.


Podtaev S.,RAS Institute of Continuous Media Mechanics | Stepanov R.,RAS Institute of Continuous Media Mechanics | Smirnova E.,Perm State Medical Academy | Loran E.,Perm State Medical Academy
Microvascular Research | Year: 2015

Skin microvessels have proven to be a model to investigate the mechanisms of vascular disease; in particular, endothelial dysfunction. To analyze skin blood flow, high-resolution thermometry can be used because low-amplitude skin temperature oscillations are caused by changes in the tone of skin vessels. The aim of our study was to test the possibilities of wavelet analysis of skin temperature (WAST) for the diagnosis of impaired regulation of microvascular tone in patients with type 2 diabetes. A local heating functional test was used for the assessment of microvascular tone regulation. A control group consisted of healthy male and female volunteers (n. = 5 each), aged 39.1 ± 5.3. years. A group of patients with type 2 diabetes comprised thirteen people, seven men and six women, aged 36 to 51. years old (43.2 ± 3.4. years). The diagnosis of diabetes was made according to the criteria of the World Health Organization (WHO). The mean disease duration was 7.36 ± 0.88. years. Skin temperature oscillations, reflecting intrinsic myogenic activity (0.05-0.14. Hz), neurogenic factors (0.02-0.05. Hz) and endothelial activity (0.0095-0.02. Hz) increase greatly during local heating for healthy subjects. In the group of patients with type 2 diabetes, no statistically significant differences in the amplitudes in the endothelial range were observed. Relative changes in the oscillation amplitudes in patients with type 2 diabetes were markedly lower compared to the control group. The latter indicates that the WAST method enables assessment of the state of vascular tone and the effects of mechanisms responsible for regulation of blood flow in the microvasculature. © 2014 Elsevier Inc.


Kuznetsova M.V.,Russian Academy of Sciences | Maslennikova I.L.,Russian Academy of Sciences | Karpunina T.I.,Perm State Medical Academy | Nesterova L.Y.,Russian Academy of Sciences | Demakov V.A.,Russian Academy of Sciences
Canadian Journal of Microbiology | Year: 2013

Pseudomonas aeruginosa and Escherichia coli are known to be involved in mixed communities in diverse niches. In this study we examined the influence of the predominant form of cell existence of and the exometabolite production by P. aeruginosa strains on interspecies interactions, in vitro. Bacterial numbers of P. aeruginosa and E. coli in mixed plankton cultures and biofilms compared with their numbers in single plankton cultures and biofilms changed in a different way, but were in accordance with the form of P. aeruginosa cell existence. The mass of a mixed-species biofilm was greater than the mass of a single-species biofilm. Among the mixed biofilms, the one with the "planktonic" P. aeruginosa strain had the least biomass. The total pyocyanin and pyoverdin levels were found to be lower in all mixed plankton cultures. Despite this, clinical P. aeruginosa strains irrespective of the predominant form of existence ("biofilm" or "planktonic") had a higher total concentration of exometabolites than did the reference strain in 12-24 h mixed cultures. The metabolism of E. coli, according to its bioluminescence, was reduced in mixed cultures, and the decrease was by 20- to 100-fold greater with the clinical Pseudomonas strains than the reference Pseudomonas strain. Thus, both the predominant form of existence of and the exometabolite production by distinct P. aeruginosa strains should be considered to fully understand the interspecies relationship and bacteria survival in natural communities.


Kravtsov Y.I.,Perm State Medical Academy | Kicherova O.A.,Perm State Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2013

The effect of glatiramer acetate on the structure of the lipid phase of cell membranes of red blood cells, the status of lipid peroxidation and antioxidant defense system in patients with relapsing forms of multiple sclerosis. It is shown that during treatment with glatiramer acetate reduces the initially high, level of phospholipase A2, and the concentration of lipid peroxidation products - diene conjugates and Schiff bases. At the same time against the increase initially reduced activity of the antioxidant defense normal structure of erythrocyte membranes in patients with relapsing-remitting multiple sclerosis. Based on the analysis of the dynamics of laboratory parameters proved membranoprotektiv effect the drug.


PubMed | Perm State Medical Academy
Type: | Journal: Journal of hypertension | Year: 2015

To determine of visceral fat level (VFL) can be used as the obstructive sleep apnea syndrome (OSAS) severity predictor. To compare the diagnostic value of visceral fat determination and other anthropometric data and indexes.The study involved 62 patients (26 women and 36 men) mean aged 52.7810.69 years with the II-III stage of arterial hypertension, 1-3 degrees. The first group included 22 patients with mild OSAS (apnea-hypopnea index (AHI)<15), the second - 40 patient with moderate and severe OSA (AHI=15 and AHI>15). The cardiopulmonary monitoring was performed to confirm the diagnosis and to clarify the severity of OSA. The screening system ApneaLink (ResMed, Germany) was used. A non-stretchable measuring tape was used to measure waist and hip circumferences (WC and HC). The smallest abdominal circumference between the lowest rib and the iliac crest was used as WC. Waist to hip ratio (WHR) was calculated by dividing WC by the HC at the level of greater trochanters. Body mass index (BMI) is persons body mass divided by the square of his height being given in units of kg/m. VFL was measured using Omron BF 508 (Netherlands) and the method of bioelectrical impedance.In group 1 WC was significantly lower than in group 2 (107.5216.75 and 120.9016.7, -0.004). Similar results were obtained for HC (113.2317.53 and 122.7616.79, p=0.016), WHR (0.950.09 and 0.980.07, p=0.048) and BMI (35.577.59 and 39.628.66, p=0.033), respectively. VFL depended on AHI directly (r=0.39, p=0.014). VFL in group 2 was higher than in group 1 (13.914.15 and 17.045.14, p=0.04). Besides, VFL linked with WC and WHR directly in both groups (p<0.05). Thus, both the elevation of WC, HC, BMI, WHR or VFL leads to the OSAS severity increasing.The detection of VFL using bioelectrical impedance can be used to determine OSAS risk as well as other known anthropometric data and indexes.

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