Salem, India
Salem, India

Periyar University is a university located in Salem, Tamil Nadu, India. It was established by the Government of Tamil Nadu in 1997. The university is named after a social reformer Thanthai Periyar. The University Grants Commissions, New Delhi bestowed the 2f status in 1998 and 12 status in 2005 to the university. The university is accredited with NAAC. Wikipedia.

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Krishnaveni M.,Periyar University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: Bauhinia purpurea is called as Mandarai in Tamil and in English as butterfly tree. The aim of the present study was to determine the secondary metabolites and antioxidant activities of shade dried Bauhinia purpurea leaf aqueous extract. Methods: Quantitative analysis for total phenolics was done by Folin-ciocalteau method and total flavonoids by aluminium chloride method. Likewise, various antioxidant activities were assessed by following standard methods. Results: The flavonoid content was higher (160.0±6.9mg/g) compared to phenolics (126.66± 6.11mg/g). Similarly, the nitric oxide scavenging activity (258.66±4.61mg/g) and reducing power activity (141.33±2.30mg/g) was found to be higher compared to total antioxidant (81.33±6.11mg/g) and metal chelating activity (30.66±2.30mg/g). Conclusion: The results obtained reveal that Bauhinia purpurea leaf extract proves to be a good antioxidant and needs further characterization to confirm its diversified therapeutic applications.


Marimuthu K.,Periyar University | Magesh P.,Periyar University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

The response of plants towards air pollution was assessed by air pollution tolerance index, as plants are primary receptors. This study was conducted during the month of January 2014. The location selected for the study was plants located near road sides of New bus stand (study area1) and plants located near roadsides of Saradha college, Salem, Tamil Nadu, India (study area 2). Thirteen plants were selected for the study from both study areas, to know the difference in their air pollution tolerance index. Standard protocols were adopted for the analysis of pH, ascorbic acid, total chlorophyll, relative water content, airpollution tolerance index. The air pollution tolerance index was high with Albizia saman 9.85 in study area 1 and Azadirachta indica 15.56 in study area 2. The chlorophyll content was moderately higher for the plants studied in study area 1 (0.82 to 2.45mg/g) and it was low for the plants in study area 2. (0.14 to 0.53mg/g). Likewise, ascorbic acid content was good with plants located in study area 2 compared to study area 1. The air pollution tolerance index was found to be 10.22 (Study area 1) for Psidium guajava, and 15.56 for Azadirachta indica (Study area 2). All the plants studied in both the locations were found to be sensitive to pollution.


Krishnaveni M.,Periyar University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: Plants are an important source of natural phytochemicals as it biosynthesise a vast number of antioxidant compounds which differ in concentration, chemical and physical properties. Secondary metabolites are compounds in specialized cells, not directly required for basic photosynthetic or respiratory metabolism but essential for plants survival in the environment. The present study aims to quantify the secondary metabolites in plants as well as to understand various antioxidant activities. Methods: Standard methods were adopted for the analysis of secondary metabolites and antioxidant activities. Results: Phosphomolybdenum and metal chelating activity was found to be high in Delonix elata (29.4mg/g, 7.60mg/g), whereas the nitric oxide scavenging activity was found to be high with Opuntia ficus-indica (9.7mg/g), likewise reducing power assay was moderate in Alangium salvifolium (3.75mg/g). Flavonoid content was high in Tectona Grandis (10.0mg/g). Conclusion: From the obtained results, we can conclude, that presence of higher amount of flavonoids might play a major role in antioxidant activities of plants.


Krishnaveni M.,Periyar University
Journal of Pharmacy Research | Year: 2013

Aim: The plant Parthenium hysterophorus is a bitter weed, able to spread easily by wind, commonly seen in all places. In order to study the air pollution tolerance index of P. hysterophorus, biochemical changes in leaf was assessed. Secondary metabolites like phenolics, flavonoid was performed in aqueous leaf extract to study the impact of secondary metabolites mediated antioxidant activity. Antioxidant analysis justify whether the plant is growing in a stressful condition or not, because to relieve from stress it has to scavenge more free radicals to keep them alive. Methods: Standard methods were adopted for APTI and antioxidant analysis. Results: The air pollution tolerance index of this plant was 25.63. Chlorophyll content was high, whereas carotenoid was found to be low. According to our results, the flavonoid content was high suggesting its role in antioxidant activity. Among the several antioxidant assays performed for this plant, total antioxidant assay depicted significant changes when compared to other. Conclusion: The selected plant P. hysterophorus was found to be a tolerant species to pollution, its high flavonoid content might be playing a major role in imparting antioxidant potential. Likewise, high chlorophyll might be a reason for its speedy growth, the relative water content is more to manage its survival from stressful environment. © 2013, JPR Solutions.


Marimuthu K.,Periyar University
Journal of Pharmacy Research | Year: 2013

Background: Only about 2% of the world's microorganisms have been tested as enzyme sources. Enormous biodiversity of organisms improves alternative biotechnological processes justifies the search for new lipases. Enzymes are considered as nature's catalysts. Lipids constitute a large part of the earth's biomass and lipolytic enzymes play an important role in the turnover of these water insoluble compounds. Most enzymes today are produced by fermentation. The benefits offered by enzymes are specificity, mild conditions and reduced waste. It may be possible, by choosing the right enzyme, to control the product production and also unwanted side reactions are minimized due to specificity of enzymes. Objectives: To screen, isolate and identify lipase producing organism from oil contaminated soil sample at Salem District, Tamil Nadu, India, in order to optimize the growth conditions and to assess the activity of lipase as an attempt to produce wealth from waste. Methodology: Morphological, Biochemical characterization of the isolate was evaluated and final confirmation was done by 16S rRNA gene sequencing. Optimization of different parameters were carried out to find the lipase activity. Results: 16S rRNA gene sequencing confirms the organism as Staphylococcus hominis MTCC 8980 and the strain was named as MK-1. The sequence was submitted in GenBank under the accession number JX961712. The G + C content was found to be 51.5%.Maximum lipase production was found to be 17.8 U/ml at 48hr incubation period and 14.7 U/ml at pH7 and at 40°C it was found to be 22.3 U/ml. Among the oil sources selected, olive oil was found to be a best lipase producer, as it produces 13.5 U/ml. Among the organic nitrogen sources selected yeast extract showed 19.5 U/ml, 22 U/ml in Triton X100 and 14.6 U/ml in Hexane. Ca2+induces lipase activity up to 21.5 U/ml whereas Hg2+, Ni2+ inhibits lipase activity. Conclusion: S. hominis was effective in producing lipase in moderate amount with the provided nutritional factors in the lipase production medium. © 2013, JPR Solutions.


Krishnaveni M.,Periyar University
Drug Invention Today | Year: 2013

Aim: To understand what is transfer factor and its significance in stimulating immune system which is necessary for the general maintenance of health. Methods: Articles were collected from net sources. Results: Basics, mechanism of action, safety aspects of transfer factor were discussed in this review. Diseases showing positive result with transfer factor treatment are tabulated. Conclusion: From this it is concluded that it is a dialyzable, active protein initiator molecule able to transfer cell mediated immunity from healthy donor to recipient who is non-immune thus keeping one away from infection. © 2013 JPR Solutions. Published by Reed Elsevier India Pvt. Ltd.


Krishnaveni M.,Periyar University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Objective: Environmental concern is a global issue. As a citizen of India, we must care about the environment where we are living to be aware of the upcoming threats. Hence, this study was aimed to analyse the biochemical changes in plants and their ability to tolerate pollution a common stress factor prevailing in the environment in order to know their tolerance, sensitivity. Methods: Standard methods were adopted for ascorbic acid, pH, chlorophyll, relative water content, air pollution tolerance index analysis. Results: Highest ascorbic acid content (4.65mg/g) was observed in Albizia lebbeck. pH was acidic in Delonix elata. Water content was found to be high for almost all the plants selected and chlorophyll was high with Albizia amara (24.38mg/g) and Caesalpinia pulcherrima (24.19mg/g). The air pollution tolerance index falls in the range of 06.75 -21.80. Conclusion: The changes in air pollution tolerance index are biochemically induced due to the surrounding environmental condition. Thus, it is concluded that Albizia amara was found to be an intermediately tolerant species whereas all the other species were found to be sensitive.


Devipriya B.,Periyar University | Kumaradhas P.,Periyar University
Chemico-Biological Interactions | Year: 2013

A molecular docking analysis and quantum chemical calculation coupled with the charge density analysis have been carried out to understand the conformational change, charge density distribution and the electrostatic properties of HAT inhibitors curcumin and its derivatives (cinnamoyl compounds) in the active site of p300. The nearest neighbours, the shortest intermolecular contacts between the inhibitors and receptor p300; their binding energies were calculated from molecular docking analysis. A high level quantum chemical calculations were performed using density functional theory (DFT-B3LYP) with the basis set 6-311G// combined with the theory of atoms in molecules (AIM) for the inhibitors in gas phase and in the active site of p300. It is observed that, when the molecules present in the active site of p300, relatively, their geometrical, bond topological and the electrostatic properties are significantly altered. The comparative study on the geometrical and electrostatic properties of these three inhibitors in gas phase and amino acid environment gives an insight on the molecular flexibility and the exact modification of electrostatic interaction of the inhibitor in the active site of p300. These fine details at electronic level allow to understand the exact drug-receptor interaction. © 2013 Elsevier Ireland Ltd. All rights reserved.


Buvaneswari N.,Periyar University | Kannan C.,Manonmaniam Sundaranar University
Journal of Hazardous Materials | Year: 2011

Effluents releasing from dyeing industries directly affect the soil, water, plant and human life. Among these dyes, plant poisoning, soil polluting and water polluting nature of organic dyes are not yet identified. The plant poisoning and non-poisoning organic dyes are identified through adsorption mechanism of cationic malachite green (MG) and anionic methyl orange (MO) on brinjal plant root powder (cellulose). The positive ΔHo (44kJmol-1) of MG higher than 40kJmol-1 confirmed the adsorption of MG on cellulose is chemisorption and the negative ΔHo (-11kJmol-1) less than 40kJmol-1 showed that the adsorption of MO on cellulose is physisorption. The ΔGo values for the adsorption of MG and MO on BPR are not much increased with increase of temperature which indicated that the adsorption is independent of the temperature. The entropy change for the adsorption of MG and MO has proved that the MG (+ΔSo) has less disorder at the adsorption interface and MO (-ΔSo) has the high disorder at the adsorption interface. The recovery of both dyes has been studied in water at 80 °C on BPR surface and observed that the MO recovery is 95% and MG is 10%. The poor desorption of MG is due to the strong chemisorption on BPR (cellulose) surface proves its plant poisoning nature. The high recovery of MO due to physisorption mechanism proves that MO is not poisoning the plant. © 2011 Elsevier B.V.


Krishnaveni M.,Periyar University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014

Objective: The main objective of this study is to assess the secondary metabolites and antioxidant activities of Terminalia catappa nut as it is not a commercialized nut. Materials and Methods: The secondary metabolites and antioxidant activities were experimented by adopting recommended standard procedures using aqueous extract of T. catappa nut powder 25, 50, 75, 100 mg. Results: The total phenolics content was higher on comparison with flavonoid content. Similarly, among the antioxidant activities, nitric oxide scavenging (257.33±2.30 mg/g) as well as reducing power activity (142.66±6.11 mg/g) was higher compared with total antioxidant (82.66±6.11 mg/g) and metal chelating activity (64.66±2.30 mg/g). Conclusion: The results obtained shows that it contained phenolics and flavonoid, which in turn induces antioxidant activities. Hence, this might act as a potential antioxidant, and needs further characterization and purification. © 2014 Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.

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